Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Nurr1"”.
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BTK functions as a corepressor of Nurr1 in human neural stem cells
Nurr1이 TH 유전자의 발현을 조절할때 세포의 분화정도에 따라 새로운 cofactor를 유도하여 complex를 형성하게되는데 미분화신경줄기세포에서는 BTK를 분화세포에서는 PARP를 유도한다.
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Δημιουργία τράπεζας πληροφοριών Ελλήνων παρκινσονικών και εύρεση νέων και γνωστών μεταλλάξεων του γονιδίου NR4A2 και η λειτουργική τους σημασία
… για την εμφάνιση της νόσου είναι και το γονίδιο Nurr1 (NR4A2). Το Nurr1 ανήκει στην υπο-οικογένεια NGFI-B (Nerve Growth Factor-Induced clone B) των ορφανών υποδοχέων. Εκφράζεται στους πυρήνες των κυττάρων του κεντρικού νευρικού συστήματος, και ιδιαίτερα στους ντοπαμινεργικούς νευρώνες. Είναι …
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Investigating the Role of the PGF2 Alpha/Calcineurin-Signaling Pathway in the Regulation of Adipogenesis
… findings to identify the IL-11 cytokine and the Nurr1 orphan nuclear hormone receptor as functionally important downstream transcriptional targets of the PGF2α/calcineurin-pathway involved in the inhibition of adipocyte differentiation. In the case of IL-11, we show that this cytokine acts …
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Generation of midbrain dopaminergic neurons in vivo and in vitro: the role of Neurogenin2
… TH-positive cells were detected when Nurr1 was over-expressed in the cultures. The frequency with which this occurred, and the morphology of the TH-positive cells, differed from the results obtained when over-expressing Nurr1 in forebrain-derived expanded cells. This suggests that …
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The role of the dopaminergic neurotrophin growth/differentiation factor-5 in the developing rat ventral midbrain
… neurons that were dopaminergic. The numbers of Nurr1-positive cells were not affected by GDF-5 treatment, but GDF-5 did increase the numbers of Nurr1- positive cells that expressed tyrosine hydroxylase (TH). Taken together this data indicated that GDF-5 increases the conversion of …
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Role of miR-19a-3p and miR-19b-3p in microglia activation and neuroinflammation
… on the expression of the neuroprotective genes Nurr1 (Nr4a2) and Nur77 (Nr4a1) following microglia activation and SCI. Results: Findings from Aim 1 revealed that mimics of miR-19a or miR-19b enhanced microglia activation, indicated by increased pro-inflammatory cytokine expression and decreased …
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Mechanismen der Entwicklung des zerebralen Kortex
… Expressionsmuster von neun Genen (Ppp1r1b, Nurr1, Flrt3, Hop, Hippocampus specific 1, Dct, Ebf3, NRIP1, Slc1a3) wurden im Detail beschrieben. Ferner wurde das kleinste bekannte Protein mit Homeodomäne (Hop) als Gen mit zeitlich-räumlich regulierter Expression im sich entwickelnden zerebralen …
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Identification and characterization of genes expressed by the midbrain dopaminergic neurons
… that neither HNF3a nor Olf-1/Ebf is regulated by Nurr1 or the En genes. Thereby suggesting that multiple parallel pathways control the development of the mDA neurons.
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Investigating the Regulation and Function of the NR4A Nuclear Receptors in Cancer
… (NR4A), which includes the NR4A1 (Nur77), NR4A2 (Nurr1), and NR4A3 (Nor-1) genes, has been implicated in adult solid tumors and has been characterized as pro-tumorigenic mediator of cell proliferation, transformation, migration, and drug resistance. Alternatively, in leukemia, NR4A1 and NR4A3 have …
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Derivation of next generation research models of Parkinson’s disease
… of combination of (ATOH1 or NGN2), FOXA2, LMX1A, NURR1, PITX3, SOX6, and MSX1 revealed three distinct TH-positive neuronal clusters. However, these neurons were also found to be positive for PRPH, a peripheral nervous system marker. The characterization of TH-positive neurons induced by ATOH1 …
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Neurodegeneration und Neuroprotektion bei der Parkinson-Krankheit: Untersuchungen von β-Carbolinen und dem Dopaminagonisten Lisurid in der dopaminergen mesencephalen Primärzellkultur des Mausstammes C57Bl/6
… Wnt1, Wnt5a) und Transkriptionsfaktoren (En1, Nurr1, Pitx3), die für die Differenzierung und Entwicklung DA Neurone entscheidend sind, durch die Behandlung mit 9-Me-BC hochreguliert. Zusätzlich erhöhte sich die Expression der DA Markergene Aldh1a1, Dat und Th. Dabei war die Hochregulierung der …