Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Nup98"”.
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Evaluation of the actin architecture in dysplastic megakaryocytes expressing the NUP98-HOXD13 leukemic fusion gene
… Transgenic mice that express the NUP98-HOXD13 (NHD13) fusion gene is a model for MDS and recapitulates the key features of MDS. The study investigated the hypothesis that expression of NHD13 disrupts actin architecture during MK differentiation leading to macrothrombocytopenia. To …
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A Proteomic Approach to Elucidating the Function of Picornavirus 2A Protease
… that it makes surgical strikes against eIF4G and Nup98, key players in host protein synthesis and nucleocytoplasmic trafficking of proteins and RNA, respectively. We subsequently utilized those protease expression platforms in combination with transport reporter assays to interrogate nuclear …
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Development of New Photocrosslinking Approaches to Discover Binding Partners of O-GlcNAc-Modified Proteins
… to a heavily O-GlcNAc-modified nucleoporin NUP98 and NUP98 leukemogenic fusions, produced under chromosomal translocation, to gain insight into the mechanism of NUP98 fusion-mediated cell transformation in leukemia. The wild-type nucleoporins are associated with nuclear trafficking. In …
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Toxic PRn Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Block Nuclear Import and Export
… functions. Purified FG domains of Nup54 and Nup98, both identified in our proteomics study as PRn targets, polymerized into structurally labile, cross-β sheet fibers under physiological conditions. Several lines of evidence suggested that the polymerized state of FG domains is relevant to …
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Identification of SPINK2 as biomarker of primary chemoresistance in acute myeloid leukemia and its biochemical role in normal bone marrow.
… (DEGs) sia in soggetti con riarrangiamenti NUP98, spesso presenti nella condizione PIF-LAM, sia in pazienti PIF. Tra questi, SPINK2 rappresenta il trascritto maggiormente espresso nei soggetti PIF-LAM. Questo gene codifica per un inibitore di serin-proteasi tripsina-simili, appartenente alla …
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Altered Kinetics of Non-Homologous End Joining Mediated DNA Repair in Mouse Models of Aging and Leukemia
… the immune system, transgenic mice expressing NUP98-HOXD13 (NHD13) were analyzed for B lymphocyte differentiation, peripheral development, CSR, and antibody production. The results showed impaired B cell development and antibody production, which worsened with antigenic stimulation, suggesting …
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Ire1 regulates cyp11a1 transcription to mediate steroidogenesis in the ovary
… the endoplasmic reticulum. IRE1 colocalizes with Nup98, a nuclear localized marker, in the nuclear membrane in large, oligomeric punctate structures. Since IRE is necessary to mediate CYP11A1 expression, we sought to determine if IRE1 endoribonuclease activity is required for CYP11A1 expression. …
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Genetic and Epigenetic Interactions in in vivo and in vitro Reprogramming
… involving HOX genes themselves: e.g. NUP98-HOXA9) and with other disease-initiating translocations: e.g. MLL translocations and inv(16)). However, HOX genes are also highly expressed in many AML samples without translocations; the mechanism that causes "dysregulation" in these cases is …
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Structure and Organization of Nuclear Pore Proteins
… only a limited effect on Nup54, and prevented Nup98 from localizing to the pore, indicating that FG-FG interactions are not dominant in determining order. Ameliorating active transport, and disassociation of cargo from the NPC had no effect on the behavior of the FG domains. Taken together, …
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The Mechanisms of HOXA9-mediated Acute Myeloid Leukaemia Maintenance
… an established therapeutic target: KMT2A-fusion, NUP98-fusion and mutated NPM1 driven AMLs not only highly express HOXA9 but also depend on HOXA9’s expression for survival, whereby downregulation of HOXA9 is associated with differentiation and apoptosis. Despite its established causative roles in …