Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Numb"”.
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Uncovering novel actions of numb and aryl hydrocarbon receptor in the pituitary
… a novel endogenous function for the gene Numb, as well as both intrinsic and extrinsic effects of aryl hydrocarbon receptor activation, on pituitary hormone producing cells. The adaptor protein Numb was originally described as an important mediator of asymmetric cell division during …
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Function and Regulation of the Cell Fate Determinant Numb in Polarized Epithelial Cells
… is observed in disease states, including cancer. Numb is an adaptor protein that functions in regulating endocytic trafficking events. Numb was originally identified in Drosophila as an asymmetrically localized cell fate determinant, and was subsequently found to be conserved in vertebrates. In …
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Asymmetric localization of prospero and numb specifies cell fates in the Drosophila CNS
… in generating differences in sibling cells. The numb protein is asymmetrically localized to the cortex of dividing precursor cells in the Drosophila central and peripheral nervous systems. numb is then segregated into only one of the progeny cells where it is necessary and sufficient to …
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ENDOCYTIC CONTROL OF CELL-AUTONOMOUS AND NON-CELL-AUTONOMOUS FUNCTIONS OF P53
NUMB is a multifunctional adaptor protein historically recognized for its role in determining cell fate decisions through inhibition of NOTCH signaling, a process achieved via endocytic trafficking. Subsequently, NUMB has emerged as a significant tumor suppressor, particularly in the context of …
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Ikkalpha Mediated Notch1 Activation Promotes Tumorigenesis Via Foxa2 Suppression
… activity and leading to decreased NUMB expression, and further activates the downstream NOTCH pathway and promotes cell proliferation and tumorigenesis. Moreover, we found that levels of IKKa, pFOXA2 (S107/ 111), and activated NOTCH1 were significantly higher in hepatocellular …
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Function analysis of Xenopus NumbL in the context of primary neurogenesis
Mitglieder der Numb Protein-Familie in Vertebraten haben vielfältige Funktionen während der frühen Embryogenese, einschließend einer essentiellen Rolle in der Entwicklung des Nervensystems. Numb Proteine interagieren als Gerüst-Proteine mit vielen Interaktionspartnern und können demnach mehrere …
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Untersuchung zur Rolle von Notch1 in T-Zellentwicklung und Lymphomgenese
… Zytosol durch Wechselwirkung mit Proteinen wie Numb oder Deltex1 moduliert werden. Angesichts der Fähigkeit, die Proliferation unreifer Zellen aufrecht zu erhalten, kann eine aberrante Expression von Notch1 zur Entstehung von Neoplasien beitragen. Numb wird eine wichtige Rolle in der Regulation …
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Dirge in Georgia Minor
… blued steel blackens palms, ashen knuckles wrung numb—the crossing and relaxing of so many pairs of fingers begging release, as we carry in one last finger-fold our will.
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Dirge in Georgia Minor
… blued steel blackens palms, ashen knuckles wrung numb—the crossing and relaxing of so many pairs of fingers begging release, as we carry in one last finger-fold our will.
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ANALYSIS OF TWO NOVEL COMPLEXES THAT REGULATE NEUROBLAST SELF-RENEWAL AND ASYMMETRIC DIVISION IN DROSOPHILA MELANOGASTER
… kinase C (aPKC) and cell fate determinant Numb, as well as mitotic spindle orientation in neuroblasts. The other player is Drosophila cytoplasmic dynein light chain 1, also named Cut up (Ctp). Ctp localizes at centrioles and controls the mitotic spindle orientation in neuroblasts. Ctp …
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Robotic Work-Space Sensing and Control
… sensors, in a sense leaving the robot blind and numb. Using external sensors, such as cameras and force sensors, allows the robot to detect the existence and position of objects in an unstructured environment, and to handle contact situations not possible using only position control. This thesis …
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Classical stoicism and romantic passion : the golden mean in Arnold's "Tristram and Iseult".
… of a life that is quiet, albeit at times numb, wins out over his endorsement of a life which promotes powerful feelings that culminate in destruction.
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Truckin' : the genetic algorithm way
… are moderately successful. This is likely due number of strategies available to the trucks. By increasing the numb algorithm may produce trucks of superior genetic structure.
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The relationship between nostalgia, social exclusion, and empathy
… and can prevent people from becoming emotionally numb after being excluded
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A place in the city to celebrate the cycles of nature
… our individuality is crushed or until we go numb. Alternatively, we can spiral in to our uniqueness while growing more and more delinquent of the responsibility owed to the whole. Corporate Icon Skyscrapers, Oppressive Anonymous Housing Blocks, and MacDonald Kings will continue to exist and …
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On Robotic Work-Space Sensing and Control
… limited use of sensors leaves robots blind and numb, unaware of what is happening in their surroundings. Whereas equipping a system with sensors has the potential to add new functionality and increase the set of uncertainties a robot can handle, it is not as simple as that. Often it is difficult …
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Mandibular anesthesia for endodontic procedures : a comparison of the mandibular block combined with a lingual supplemental injection versus the periodontal ligament injection gun delivery system
… in rendering vital mandibular teeth totally numb. A large number Of PDL-injected teeth needed mandibular blocks in order to obtain access for the intrapulpal injections. This required additional manipulations of the patients. 5. Should not be used on undebrided areas or teeth with suppurative …
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Interplay between collapsin response mediator protein 2 (CRMP2) phosphorylation and sumoylation modulates NaV1.7 trafficking
… Nedd4-2 as well as endocytosis adaptor proteins Numb and Eps15. Collectively, my findings identify a novel mechanism for regulation of Nav1.7.
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LNX1 and LNX2 in the central nervous system: linking behavioural, cellular and molecular perspectives
Ligand of Numb protein-X (LNX) proteins are a conserved family of E3 ubiquitin ligases with emerging roles in neuronal development and function. In the central nervous system, LNX1p70/p62 isoforms and LNX2 show dynamic expression during development, with nearly undetectable protein abundance in the …
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DISSECTING THE ROLE OF GOLGI TRAFFIC IN BRAIN DEVELOPMENT ACROSS HEALTH AND DISEASE: A LESSON FROM COG5-CDG STUDIES
… in most CDG patients. Despite the increased number of diagnosed patients, the cell biological mechanisms linking defective Golgi glycosylation and neurodevelopmental manifestations are currently unknown. Here we try to fill this gap by investigating the influence of GA on cell identity and …
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