Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Nucleus pulposus"”.
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Mechanobiology of the nucleus pulposus: The effect of hydrostatic pressure and glucose deprivation on nucleus pulposus cell sub‐populations
The nucleus pulposus of the intervertebral disc contains two cell types: notochordal (NC) and chondrocyte‐like mature nucleus pulposus (MNP) cells; the ratio of which changes with species, age and health. Intervertebral disc (IVDs) that contain predominantly MNP cells are susceptible to …
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An in Vitro Microenvironment for Nucleus Pulposus Regeneration
… in disc failure. At the center of the disc, the nucleus pulposus (NP) resides in a hypoxic environment where degeneration is thought to begin. Initially, nucleus pulposus cells (NPCs) display altered morphology and function, along with increased rates of cellular senescence and apoptosis. Though …
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Physical analysis of collagen-GAG composite scaffolds for nucleus pulposus tissue regeneration
… study biomaterial scaffolds for regeneration of nucleus pulposus were developed by freeze drying slurries with different proportions of collagen II (CII), chondroitin-6-sulfate (CS), and hyaluronic acid (HA). The scaffolds were analyzed using biochemical assays to determine final composition. …
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Development of an Injectable Methylcellulose Hydrogel System for Nucleus Pulposus Repair and Regeneration
… believed to begin in the central, gelatinous nucleus pulposus (NP) region of the tissue, for which there are few preventative therapies. Current therapeutic strategies include pain management and exercise, or surgical intervention such as spinal fusion, none of which address the underlying …
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Cadherin-Mediated Cell-Cell Interactions Regulates Phenotype And Morphology of Nucleus Pulposus Cells Of The Intervertebral Disc
<p>Juvenile nucleus pulposus (NP) cells of the intervertebral disc (IVD) are large, vacuolated cells that form cell clusters with numerous cell-cell interactions. With maturation and aging, NP cells lose their ability to form these cell clusters, with associated changes in NP cell phenotype, …
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Tissue-Engineered Annulus Fibrosus Repair and Nucleus Pulposus Augmentation in Pre-Clinical Models of Intervertebral Disc Degeneration
… the outer fibrous ring of the IVD, which allow nucleus pulposus (NP), the gelatinous core, to herniate and impinge on surrounding neurological structures. Current surgical treatment options are unable to effectively repair the IVD, leading to further degeneration and reherniation. This work aims …
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Experimental and finite element analysis of mechano-electrochemical effects in intervertebral disc biomechanics
… that fluid velocity may be augmented through the nucleus pulposus via ionic osmotic pressure gradients which consist of fixed charge, mobile ion and electrical potential gradients. A novel method to fully characterise, for the first time, the Poisson's ratio of the disc was developed. Poisson's …
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Poly(N-Isopropylacrylamide)-based scaffolds for tissue engineering applications
… applications, specifically spinal injury and nucleus pulposus replacement. Poly(N-isopropylacrylamide), denoted PNIPAAm, is a synthetic polymer with hydrophilic properties at room temperature, but above 32C the chains become hydrophobic and entangle to form physical crosslinks. This …
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Load bearing regenerative repairs for the cartilaginous soft tissue of the intervertebral disc
… load bearing soft tissues such as the nucleus pulposus in the intervertebral disc are affected by degenerative diseases and physical injury, which if not treated early can initiate a progressive decline in joint function and result in lower back pain. Early treatment options to repair …
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Polymer Composite Spinal Disc Implants
… results for vertebral endplate connection and nucleus pulposus internal pressure, for the correction of disc degeneration in the spine. The three-part composite samples needed to demonstrate good shock absorption and load distribution while maintaining strength and flexibility, and removing the …
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Effects of cytoskeletal protein disruption on the deformation of MSCs during chondrogenesis
… into the chondrocyte-like cells found within the nucleus pulposus of the adult intervertebral disc. This study examines one determinant of the cellular mechanotransduction pathway, an important aspect of cell-based therapies. Specifically, we investigate the role of cytoskeletal proteins on …
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The effect of position on the lumbar intervertebral disc.
… positions. The sagittal plane migration of the nucleus pulposus (NP) of each lumbar IVD in each position was measured from the sagittal and axial pMRI scans. Within and between group inferential analysis was performed using nonparametric tests. Both the asymptomatic and DLBP subjects …
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Cellular And Mechano-Active Material Approaches To Improve Disc Repair After Herniation
… to transmit forces throughout the spine. A nucleus pulposus (NP) core is surrounded circumferentially by the annulus fibrosus (AF), which together transmit loads to adjacent vertebra. Although this specialized structure evolved over millennia, the disc failed to develop mechanisms for …
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Characterisation of Ovine and Human Vertebral Endplates using X-ray Microtomography: the Effects of Degeneration on Structure.
… increased biochemical exchange with the central nucleus pulposus of the disc and by the requirement of strong anchorage of disc fibres for mechanical support in the peripheral regions. Cranial VEPs were thicker, more porous and showed higher bone mineral density than their caudal counterparts. …
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Extracellular Matrix Degradation and Mechanical Integrity of Degenerated Human Annulus Fibrosus from Surgical Specimens
… of age-related AF deterioration that precedes nucleus pulposus-centric degenerative changes, and establish MMP-3 as a mechanistically plausible biomarker linking proteolytic remodeling to interlamellar mechanical failure. This work provides a foundation for future investigation of active enzyme …
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An In Vivo histological, and In Vitro biomechanical study of nucleus replacement with a novel polymeric hydrogel
Nucleus replacement has recently come into favor as a possible treatment for Degenerative Disc Disease. Replacing degenerative nucleus tissue with a synthetic material that mimics healthy nucleus tissue may restore normal function and biomechanics to the disc and delay or obviate the need for more …
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Stem cell matrix and cartilage regeneration
… would also be beneficial to the chondrocyte-like nucleus pulposus cell (NPC) rejuvenation from human herniated discs and whether fetal DECM is superior to adult DECM. Although both SDSC and NPC deposited DECMs (SECM and NECM) significantly enhanced NPC proliferation, only NECM expanded NPCs …
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Mechanics of biomimetic materials for tissue engineering of the intervertebral disc
Tissue engineering offers a paradigm shift in the treatment of back pain. Engineered intervertebral discs could replace degenerated tissue and overcome the limitations of current treatments that disrupt the biomechanics of the spine. New materials, which exhibit sophisticated mechanical responses, …
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Investigating the Role of TRPV4 as a Mechanoreceptor in the Intervertebral Disc
Transient Receptor Potential Cation Channel Subfamily V Member 4 (TRPV4) is a cell membrane Ca2+ channel that regulates intracellular calcium levels in response to mechanical stimuli. Recent studies have demonstrated that TRPV4 is required for the induction of extracellular gene expression in …