Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Nucleosome sliding"”.
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Chromatin Structure of Schizosaccharomyces Pombe: From the Lowest to the Highest Orders of Folding
… with conventional methods for measuring the nucleosome repeat length, to determine the repeat length of Schizosaccharomyces pombe chromatin. I obtained a result of 156 $\pm$ 2 bp. Equivalent results are obtained using a psoralen crosslinking method for measuring the repeat length in viable …
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Biophysical Analysis of S100A12 and the Nucleosome Core Particle
… the calcium binding protein S100A12 and the nucleosome core particle. These studies are unified by a shared emphasis on how physical forces govern biological function.</p> <p>In the first part, we explore calcium mediated allostery in S100A12, focusing on the distinct roles of its two EF-hand …
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DYNAMICS OF NUCLEOSOME REMODELING BY ATP-DEPENDENT CHROMATIN REMODELERS
… on DNA, break histone-DNA contacts, and mobilize nucleosomes. However, the final outcomes of nucleosome remodeling are diverse - nucleosome sliding, dimer exchange, nucleosome disassembly, and nucleosome conformation alteration. This study sheds light on how different chromatin remodelers catalyze …
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Structural and functional consequences of platinum anticancer drug binding to free and nucleosomal DNA
… DNA modified by sitespecific platinum adducts. Nucleosome core particles containing a single 1,3-cis-{Pt(NH 3)2}2+_ d(GpTpG) intrastrand cross-link were synthesized and crystallized, and the X-ray structure was determined at 3.2 A resolution. The cisplatin adduct adopts a conformation facing …
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Single molecule investigations into DNA replication, recombination and repair
Double-stranded DNA breaks (DSBs) is a principal cytotoxic damage that can be repaired by several well-known repair pathways. One of the most prominent routes is the homologous recombination (HR). The mechanism of repair has been studied primarily by biochemical analysis over the years. Recent …