Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Nucleosome occupancy"”.
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Nucleosome repositioning in glioblastoma
… causes. In particular, the positioning of nucleosomes along the genome determines the accessibility of DNA to regulatory proteins and therefore modulates gene expression. In this project I investigate nucleosome positioning in relation to other features, such as transcription factor (TF) …
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Effect of Naturally Occurring DNA Modifications on DNA Structure and Packaging
… DNA (dsDNA) coils around histones to form nucleosomes. Arrays of these nucleosomes bundle together to generate chromatin. Most DNA-related processes require interactions between chromatin-protected DNA and cellular machinery. Access of cell machinery to genomic DNA is partially regulated by …
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Roles of the Histone Chaperone FACT in Drosophila Gene Regulation and Chromatin Architecture
… contribute to the disassembly and reassembly of nucleosomes in the wake of RNA polymerase II passage through chromatin. In yeast, mutation of FACT subunits leads to decreased nucleosome occupancy at the promoters and transcribed regions of genes. In addition, genetic experiments suggest that …
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The role of Arabidopsis thaliana heterochromatin component H2A.W in meiotic recombination
… with a high DNA density and is enriched in nucleosome occupancy and specific chromatin modifications, including H3K9me2 and DNA methylation. Analysis of histone H2A variants via ChIP-sequencing has revealed that H2A.W is enriched in the heterochromatin. By combining cytogenetic, genetic and …
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Towards a Complete Transcriptional Regulatory Code: Improved Motif Discovery Using Informative Priors
… present in the form of chromatin--wrapped around nucleosomes--with certain regions being more accessible to TFs than others. It has been shown that functional binding sites are generally located in nucleosome-free regions. We use nucleosome occupancy predictions to compute a novel positional prior …
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Protein-DNA Binding: Discovering Motifs and Distinguishing Direct from Indirect Interactions
… different types of biological information (e.g., nucleosome positioning information) to guide the search for DNA binding sites toward regions where these sites are more likely to occur (e.g., nucleosome-free regions). </p><p>We use transcription factor (TF) binding data from yeast chromatin …
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Statistical analysis and modeling of nucleosome positioning
Nucleosome is the fundamental building block of eukaryotic chromatin. The precise location of nucleosome along the genome plays a central role in gene regulation by controlling the accessibility of genetic information encoded in DNA. Understanding the principles underlying the establishment of …