Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Nucleoside analog"”.
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DEVELOPMENT OF 4'-ETHYNYL-2'-DEOXYCYTIDINE (EdC), A REPLICATION-STRESS INDUCING NUCLEOSIDE ANALOG PRODRUG WITH PREFERENTIAL ACTIVITY IN LEUKEMIA AND LYMPHOMA SUBTYPES
Anticancer nucleosides are effective against solid tumors and hematological malignancies, but typically are prone to nucleoside metabolism resistance mechanisms. Using a nucleoside-specific multiplexed high-throughput screening approach, we discovered 4’-ethynyl-2’-deoxycytidine (EdC) as a …
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Spectroscopic analysis and synthesis of nucleoside analogs for lethal mutagenesis
… to existing therapeutics. A novel antiviral nucleoside analog, 5-Aza-5,6-dihydro-2'- deoxycytidine (KP1212), employs the mechanism of lethal mutagenesis to avoid the problem of drug resistance and use the virus's high mutation rate against it. KP1212 is incorporated into DNA by HIV reverse …
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UNDERSTANDING THE NEUROVIRULENCE OF ENTEROVIRUS 71
NITD008, an adenosine nucleoside analog, was shown to fully protect EV71-infected two-week old AG129 mice from morbidity and mortality. NSC-34, a murine motor neuron cell line, was found to be susceptible and permissive to EV71 infection, with S41 strain being the most infectious in NSC-34 cells …
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Host-Based Mechanisms of Ribavirin Resistance: Implications In Treatment Response of Hepatatis C Virus Infection
… of pegylated interferon and ribavirin (RBV), a nucleoside analog. While RBV improves treatment outcome, and will likely be an important component of therapy with next-generation viral inhibitors, RBV’s mechanism is controversial. Most of RBV’s proposed mechanisms require RBV import into cells. …
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Equilibrative Nucleoside Transporter Mediated Drug Disposition Across the Blood-Testis Barrier
… and chemotherapeutic agents are classified as nucleoside analogs, which resemble endogenous nucleosides essential for nucleic acid synthesis and spermatogenesis. Due to similarity in chemical structure, these drugs are suspected to be substrates of the equilibrative nucleoside transporters …
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Bundibugyo Versus Zaire Ebolaviruses: Examination of the Polymerase Complex as a Therapeutic Target
… of small molecule inhibitors, of which the nucleoside analog remdesivir emerged as a lead candidate. Remdesivir was found to be highly effective at inhibiting primary transcription, and delayed treatment required a significantly higher concentration. Use of remdesivir was more effective at …
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Structural determinants of murine leukemia virus (MLV) reverse transcriptase (RT) important for fidelity and drug resistance in vivo
… important for resistance to the antiviral nucleoside analog, 2', 3'-dideoxy-3 '-thiacytidine (3TC). This is in contrast to results observed with human immunodeficiency virus type 1 (HIV-1) RT. These results establish a sensitive in vivo assay for identification of structural determinants …
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Structural determinants of murine leukemia virus reverse transcriptase that are important for template switching, fidelity, and drug resistance
… of drug-resistance to the antiretroviral nucleoside analog 2',3'-dideoxy-3 '-thiacytidine (3TC), an inhibitor of wild-type human immunodeficiency virus type 1 (HIV-1) RT. We tested our hypothesis that a valine residue at the 223 position in YVDD motif of the MLV RT leads to a natural high …
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Functional consequences of cytosine methylation in mitochondrial DNA catalyzed by DNA methyltransferase 1
… susceptible to pharmacologic inhibition by the nucleoside analog 5-aza-2’-deoxycytidine (5-aza-dC). NRF1 and PGC1α, transcription factors that activate nuclear-encoded mitochondrial proteins in response to oxidative stress, were observed to up-regulate expression of mtDNMT1. Loss of p53, a tumor …
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Computational and Pharmacological Approaches to Design Novel Allosteric Thymidylate Synthase Inhibitors
… The assay measures the uptake of a fluorescent nucleoside analog, which was shown to correlate with TS inhibition induced by direct and indirect inhibitors or with genetic loss of TS. Studies were conducted with raltitrexed (RTX) (active site targeted TS inhibitor) and GLU on paired isogenic …
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Foamy Virus Enzymes - Activity, Regulation and Resistance
… similar. However, their behavior towards the nucleoside inhibitor azidothymidine is different. This nucleoside analog inhibits the replication of foamy viruses by terminating polymerization. Prototype foamy virus was not able to develop resistance against azidothymidine, but we succeeded in …
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Transient Metabolic Alterations Induced by Chemotherapeutics in Cancer Persisters
… treated with antimetabolites that act as a nucleoside analog for deoxycytidine. Overall, these results lead us to believe that cJUN, which is at the crossroads for both cell survival and apoptotic pathways, plays a significant role in persister physiology.
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Genome-Wide Dynamics of Chromatin Maturation Following DNA Replication
… resolution in S. cerevisiae. It employs a nucleoside analog to specifically enrich for nascent chromatin, which can be captured following a chase over different periods of time. Thus, NCOPs resolve the structure of nascent and mature chromatin, facilitating the analysis of chromatin …
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EMISSIVE PEPTIDE NUCLEIC ACIDS (PNAS): POTENTIAL TOOLS FOR INNOVATIVE DIAGNOSTICS AND THERAPEUTICS
… S. G.; Weizman, H.; Tor, Y. A Highly Fluorescent Nucleoside Analog Based on Thieno[3,4-d]Pyrimidine Senses Mismatched Pairing. Org. Biomol. Chem. 2008, 6, 1334–1338. https://doi.org/10.1039/b801054d. (7) Maggioni, D.; Galli, M.; D’Alfonso, L.; Inverso, D.; Dozzi, M. V.; Sironi, L.; Iannacone, M.; …