Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Nucleoside Transporter"”.
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Flavonoids and Related Compounds as Nucleoside Transporter Inhibitors
<p>Mammalian nucleoside transporters can be classified into two main categories, namely, equilibrative nucleoside transporters (ENTs) and concentrative nucleoside transporters (CNTs). ENTs are ubiquitous, and mediate sodium-independent bi-directional facilitated diffusion nucleoside transport …
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STRUCTURE-FUNCTION ANALYSIS OF THE HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1
… domains 1 and 2 of the human equilibrative nucleoside transporter 1 (hENTl), in order to assess their contributions to transporter functionality. Through affinity changes in [ H]NBMPR binding, competitive inhibition profiles with ENT1 inhibitors and [ H]2- chloroadenosine uptake, these …
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Equilibrative Nucleoside Transporter Mediated Drug Disposition Across the Blood-Testis Barrier
… contraceptives and fertility treatments. Drug transporters present at the basal and apical membranes of testicular epithelial cells (Sertoli cells) facilitate the disposition of therapeutics across the BTB. Many antivirals and chemotherapeutic agents are classified as nucleoside analogs, which …
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Host-Based Mechanisms of Ribavirin Resistance: Implications In Treatment Response of Hepatatis C Virus Infection
… of pegylated interferon and ribavirin (RBV), a nucleoside analog. While RBV improves treatment outcome, and will likely be an important component of therapy with next-generation viral inhibitors, RBV’s mechanism is controversial. Most of RBV’s proposed mechanisms require RBV import into cells. …
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Validation of AXL as a Therapeutic Target in Pancreatic Cancer
… differentiated histology, lower equilibrative nucleoside transporter 1 expression and has a more inflammatory and active immune microenvironment, all of which likely contribute to improved survival. As a result, AXL-deficient PDA treated with gemcitabine show more DNA damage (γH2AX) compared to …
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Synthetic strategies for potential trypanocides
… The second part details the P2 strategy. The P2 transporter is a nucleoside transporter unique to T. brucei, which concentrates adenosine. The transporter also binds and selectively concentrates compounds that contain benzamidine and diaminotriazine P2 motifs, which can enhance the potency and …
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Purine transport in plasmodium falciparum
… has to salvage it from the host milieu through transporter(s). Knowledge of the number, selectivity and kinetic parameters of the transporters expressed by the parasite would therefore facilitate a rational purine-based chemotherapy of malaria. The rates of transport of radiolabeled purines into …
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Existence of Inhibitor of Apoptosis in Tumor Exosomes
<p>Pancreatic cancer is a deadly and aggressive disease. The only option for metastatic pancreatic cancer is chemotherapy where only the antimetabolites gemcitabine (Gem) and 5-fluorouracil (5FU) are used clinically. However, resistance to these antimetabolites remains a problem highlighting the …