Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Nucleolin"”.
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The c-Myc/TBX3/nucleolin/Hsc70 signalling axis in breast cancer
… identified and from this list three partners viz nucleolin, Hsc70 and HnRNP K were validated by immunoprecipitation and colocalization experiments. Importantly, results show that the interaction of TBX3 with Hsc70 is required for TBX3 protein stability and that nucleolin and TBX3 cooperate to …
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The Role of Nucleolin In B-Cell Lymphomas and Fas-Mediated Apoptotic Signaling
… identified high scoring peptides derived from nucleolin, a nuclear protein known to be overexpressed in cancer.</p> <p>We confirmed binding of nucleolin to Fas and the presence of nucleolin-Fas complexes on the surface of lymphoma cells. Using deletion mutants of nucleolin, we identified RBD 4 …
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The Role of Nucleolin Phosphorylation by CK2 in Regulating Cellular Fate Under Normal and Stress Conditions
<p>Nucleolin (NCL or C23) is an abundant genotoxic stress-responsive RNA binding phosphoprotein. NCL constitutes 10% of total nucleolar protein that has functions in multiple biological processes, including ribosome biogenesis, DNA/RNA metabolism, cellular response to DNA damage, cell growth, …
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The post-translational methylation of arginine in the glycine arginine rich region of CHO nucleoin
Nucleolin is a nucleolar protein important for ribosome biogenesis. Nucleolin contains a conserved glycine arginine rich (GAR) domain near its carboxy terminus. GAR domains are defined by repeating tri-peptide, (arginine -glycine-glycine (RGG)) motifs. The arginine in the RGG motif is …
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Achieving Cell-Specific Delivery of Multiple Oligonucleotide Therapeutics with Aptamer Chimeras
… efficacy, I have examined the properties of a nucleolin aptamer-mediated delivery system that targets multiple types of cancer cells, and delivers various oligonucleotide therapeutics. </p><p>The nucleolin aptamer targeted cancer cells by binding to membrane–associated nucleolin. …
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The Regulation of Microrna Biogenesis By Ribosome-Interacting Proteins
… miRNA biogenesis. In one study, we identified nucleolin as a positive regulator of pri-miR-15a/miR-16-1 biogenesis. Nucleolin expression is inversely proportional to mature miR-15a/miR-16-1 expression. While nuclear localization of nucleolin increases miR-15a/16-1 expression, cytoplasmic …
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Structural and Functional Characterization of GAPR-1, a Mammalian Plant Pathogenesis-related Protein in Lipid-enriched Microdomains of the Golgi Complex
… was shown to interact with three proteins: Nucleolin, Template activating factor α (TAFIα) and HSAPRIL. In the yeast two hybrid system, the interaction of GARP-1 with Nucleolin was confirmed and shown to be dependent on the most conserved amino acid residues in GAPR-1. The interaction …
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The molecular mechanisms of pseudogene-mediated PTEN expression.
… exists at the PTEN promoter. We also show that nucleolin has the ability to bind the PTENpg1 asRNA which produces a downstream effect on PTEN gene expression. These data also provide an indication that nucleolin may be involved in the poorly understood lncRNA degradation pathway. A greater …
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Defining the Role of Secondary DNA Structures and Transcription Factors on the Transcriptional Control of the HIF-1alpha and VEGF Promoters
… nuclear ribonucleoprotein (hnRNP) K and nucleolin, respectively, both in vitro and in vivo and their potential role in the transcriptional control of HIF-1α and VEGF. In this dissertation, we demonstrate that both nucleolin and hnRNP K bind selectively to the G- and C-rich sequences, …
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The role of linker histone variant in double strand break repair
… in vivo, along with DNA-PK, the KU complex and nucleolin. Interestingly, the interaction with nucleolin only occurs in the presence of DNA damage following exposure to ionising radiation. In vitro analysis has shown that this linker histone variant is able to form stable complexes in the …
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KSHV encoded viral processivity factor, ORF59, regulates multiple pathways for viral replication
… for further study including host proteins Nucleolin and MCM4 in addition to viral protein, ORF57. Our characterization of the interaction between KSHV ORF59 and these associating factors yielded exciting new insights on host-virus interactions that we expect to be valuable for understanding …
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The regulation of the T-box transcription factor TBX3 in Luminal A breast cancer
… were identified and from this list Hsc70 and nucleolin were validated by immunoprecipitation and colocalization experiments in MCF-7 and T47D breast cancer cells. Importantly, results show that the interaction of TBX3 with Hsc70 is required for TBX3 protein stability and that nucleolin and …
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The role of T-box transcription factor TBX3 in rhabdomyosarcoma
… in vivo. This study also provides evidence that nucleolin binds to, and co - operates with, TBX3 to promote proliferation and migration of ERMS cells. Furthermore, data from initial experiments reveal that Hsc70 interacts with TBX3, to possibly increase its protein stability, and that oncogenic c …
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Investigations into Building Block Structure and Method of Preparation on the Properties of Nanomaterials
… conjugation with F3 peptide which targets to nucleolin in most tumor cells, and loaded with doxorubicin as the drug to kill the tumor cells, both in vitro and in vivo studies were performed. It was found that F3-peptide conjugated nanoparticle not only specifically bind to the tumor-associated …
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Elucidation of the roles of PTN and ISG15 in RSV cytopathogenesis: possible biomarkers of severe disease?
… identified RSV co‐receptor/entry factor, nucleolin. Our findings on the role of PTN are particularly exciting. We found differential expression of PTN in infants at greater risk of severe RSV disease compared to older infants and in those with a history of severe compared to mild RSV …
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Investigation of Genomic Instability Induced By G-Quadruplexes In The Absence of Functional to poisomerase 1 In Yeast
… that another G4-binding protein, Nsr1 or yeast nucleolin, contributes to G4-instability in yeast cells expressing Top1 mutants and provide additional evidence indicating that Top1 cleavage-defective mutants and Nsr1 interact when bound to G4s to form a potential replication block. Bioinformatic …
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Applications of functional nucleic acids in imaging, sensing and drug delivery and investigations of DNAzyme-metal interactions
… cisplatin by an aptamer that selectively bind nucleolin, an overexpressed protein by breast cancer cells. The study proved the selective cytotoxicity to breast cancer cells of the aptamer-functionalized liposome.
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Μελέτη της αντι-αγγειογενετικής δράσης των συνθετικών πεπτιδίων HB-19 και N6L
H νουκλεολίνη είναι μια πρωτεΐνη μοριακού βάρους 110 kDa και απαντάται στον πυρήνα, το κυτταρόπλασμα αλλά και στην επιφάνεια των κυττάρων, ενώ υπερεκφράζεται σε καρκινικά κύτταρα και σε ενεργά ενδοθηλιακά κύτταρα. Πρόσφατες έρευνες υποδεικνύουν την συμμετοχή της στις διαδικασίες ανάπτυξης …
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Ταυτοποίηση πρωτεϊνών που αλληλεπιδρούν με τον αυξητικό παράγοντα πλειοτροπίνη και διερεύνηση του λειτουργικού τους ρόλου
Η πλειοτροπίνη (PTN) αποτελεί έναν αυξητικό παράγοντα με ποικίλες δράσεις και σημαντικό ρόλο στην ανάπτυξη όγκων και την αγγειογένεση. Διάφοροι υποδοχείς αλληλεπιδρούν με την ΡΤΝ και διαμεσολαβούν τις βιολογικές της δράσεις, όπως η Ν-συνδεκάνη, ο ALK (κινάση αναπλαστικού λεμφώματος) και ο RPTPβ/ζ …