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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 477 for “"Nucleic acids"”.
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Molecular Recognition of Nucleic Acids
… Friedlander condensation with tetramic acids was shown to be a viable method for construction of the tricyclic portion of a CG host.
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Unexpected mechanical properties of nucleic acids
Mechanical deformations of nucleic acids (NA) play a very important role in many biological life processes. The bending persistence length of DNA is of specific interest, because so much eukaryotic DNA that stores genetic information is tightly packed inside cell nuclei, even though DNA is …
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Computational prediction of allosteric nucleic acids
Selected nucleic acid binding species (aptamers) have been shown to undergo conformational changes in the presence of ligands, and have been adapted to function as biosensors. We were interested in whether the secondary structures of aptamers could be rationally engineered to undergo ligand …
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Synthesis of aromatic peptide nucleic acids
… synthesis of two analogues of Aromatic Peptide Nucleic Acids (APNAs) monomers was successfully achieved. These Peptide Nucleic Acid analogues could be used as building blocks for the synthesis of oligomers with the DNA and RNA recognition properties of PNAs in addition to a more hydrophobic …
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Prebiotic assembly and replication of nucleic acids
… as the "RNA world", relies on replication of ribonucleic acid (RNA) before the advent of protein enzymes and deoxyribonucleic acid (DNA). Essentially, the hypothesis relies on what some researchers believe is a parsimonious claim that RNA was the central molecule of heredity and metabolic …
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Towards the synthesis of ferrocene nucleic acids
The fields of DNA chemistry and electrochemical sensing were combined in an attempt to synthesise ferrocene modified DNA. Two modified ferrocene monomers were attempted to be incorporated into oligonucleotide strands, using solid state phosphoramidite DNA synthesis techniques, and characterised …
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Metabolism of Exogenous Nucleic Acids by Ovines
Made available in DSpace on 2014-12-10T22:30:20Z (GMT). No. of bitstreams: 1 7121095.pdf: 2699265 bytes, checksum: 264f51ee1619d349e882f25cceb964da (MD5) Previous issue date: 1971
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Cas protein diagnostics for pathogen nucleic acids
Cas protein diagnostics for pathogen nucleic acids - Akashaditya Das I formulated my research goals for my PhD in tandem with a Global Challenges Research Grant awarded to the Ajioka Lab in collaboration with other labs in the United Kingdom and South Africa. The grant aimed to develop tests for …
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Functional nucleic acids as substrate for information processing
… by self-assembly and conformation dynamics of nucleic acids are possible. These underlying paradigms (self-assembly and conformation dynamics) are essential for natural information processors as illustrated by proteins. A key advantage in utilising nucleic acids as information processors is the …
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The Synthesis and Characterization of Glycol Nucleic Acids
… the properties of the simplified glycol nucleic acid (GNA). GNA is novel in the fact that nucleic acid duplexes composed entirely of GNA show thermal stabilities that are superior to those of analogous DNA or RNA duplexes. Furthermore, GNA has been shown to pair with complementary …
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Mechanisms Behind the Chaperone Activity of Nucleic Acids
<p>Understanding the interplay between nucleic acids and protein aggregation is integral to the understanding of proteostasis, aging, and neurodegenerative disease progression. Nucleic acids are known to modulate the aggregation of PrP, tau, ⍺-synuclein, and other disease relevant proteins. …
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Novel Lipid Polymer Design for Nucleic Acids Delivery
… of the most successful non-viral carriers for nucleic acids, highlighted by the approval of the first small interfering RNA (siRNA) therapy and the rapid deployment of LNP-based mRNA vaccines against COVID-19. However, achieving efficient and targeted delivery of nucleic acids to solid tumors …
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Bioorganic Studies Related to Coenzymes and Nucleic Acids
Made available in DSpace on 2014-12-10T23:01:28Z (GMT). No. of bitstreams: 1 7310047.pdf: 4655883 bytes, checksum: 280d0683f091773f276b3930f3e468c6 (MD5) Previous issue date: 1972
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Towards Enzymatic Synthesis of Uncharged Xeno Nucleic Acids
… of DNA, referred to collectively as xeno nucleic acids (XNAs), can address some such limitations. The polyanionic backbone of DNA dominates its physicochemical properties and decouples them from its information content. In this thesis, I explore two XNA chemistries with neutrally charged …
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Molecular Dynamics Study of Single Stranded Peptide Nucleic Acids
… portion of aminoethylglycine peptide nucleic acids (<em>aeg</em>PNA) has been replaced with one or more (S,S)-<em> trans</em> cyclopentyl (<em>cp</em>PNA) units. This substitution has met with varied success in terms of DNA/RNA recognition.</p> <p>In the present work, molecular …
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Proton Magnetic Resonance Studies of Nucleic Acids in Solution
Made available in DSpace on 2014-12-13T20:09:55Z (GMT). No. of bitstreams: 1 7708921.pdf: 4086111 bytes, checksum: 14ce32df731903684a4718257ea0d7c6 (MD5) Previous issue date: 1976
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