Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Nucleic acid-based therapies"”.
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Endocytosis of therapeutic macromolecules in tumor cells - Mechanistic aspects of the proteoglycan receptor function
… urgently needed. Most current pharmacological therapies have severe side effects and are seldom curative. Macromolecular drugs, and in particular nucleic acid based drugs, offer a potential remedy for this situation. Currently, the absence of efficacious and safe methods to deliver nucleic …
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Development of Carbohydrate-based Diblock Polymers for Nucleic Acid Delivery
The delivery of nucleic acids remains the major obstacle for nucleic acid-based therapies such as gene therapy and gene silencing therapies based on RNA interference. In this dissertation we have developed and studied nucleic acid delivery vehicles based on cationic diblock glycopolymers that …
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Granular Hydrogels for Localized Nanoparticle Delivery
… advanced therapeutics remains a major challenge. Nucleic acid–based therapies hold enormous promise for locally modulating gene expression and restoring skin homeostasis, but their translation is limited, among others, by the lack of simple, adaptable, and clinically relevant delivery platforms. …
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The conjugation and evaluation of hydrophobic small molecules to trazole-linked siRNAs
… in 2008 to 22.2 million by 2030. Traditional therapies, including surgery, radiation therapy, and chemotherapy, have difficulty in specifically selecting malignant tissues for destruction. To overcome these limitations, nucleic acid-based therapies, such as short interfering RNAs (siRNAs), …