Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Nucleic Acids, Nucleotides, and Nucleosides"”.
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Novel Lipid Polymer Design for Nucleic Acids Delivery
… of any protein without the need for expensive and time-consuming drug development processes. Despite the initial excitement and extensive efforts, the potential impact of RNAi in clinical settings has been limited due to challenges in delivering RNA molecules effectively and safely. In …
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Evaluating The Therapeutic Efficacy of Grb2 Inhibition In Ovarian Malignancies
… orthotopic models of ovarian cancer (OVCAR5 and SKOV3ip1) were used to study the biological effects of L-Grb2 on tumor growth. <em>In vitro</em> experiments (cell viability assay, Western blot analysis, siRNA transfection, and reverse phase protein array) were carried out to elucidate the …
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Targeting Oncogenic Mirnas With Small Molecules For Breast Cancer Therapy
<p><strong>The crucial role of microRNAs (miRNAs) in cancer pathobiology has driven the introduction of new drug development approaches such as miRNA inhibition. In order to advance miRNA-therapeutics, there is a need to develop screening strategies that can target tumors in a specific way. Small …
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Expanding inducible epithelial resistance against pneumonia: novel virus, novel receptor
… the leading infectious cause of death worldwide and presents a continuing risk among immunocompromised patients. Our work has been focused for many years on the phenomenon of inducible epithelial resistance, where activation of the innate immune response in the airway epithelium is necessary and …
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MRP4-Dependent Regulation of Fibroblast Migration
<p>Roles of cyclic nucleotides and cyclic nucleotide-dependent signaling molecules in regulating several signaling pathways including cell migration have long been known. However, the new and revolutionary concept is that it is not just the absence or presence of cyclic nucleotides, but a highly …
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The Effects of Known PCR Inhibitors on Droplet Digital PCR Performance
… PCR (qPCR) instrumentation, the current standard for the quantification of DNA, are used to detect inhibitors in samples. Droplet digital PCR (ddPCR) relies on absolute quantification of positive and negative droplets and therefore may be less susceptible to inhibition than traditional qPCR …
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Chemosensitization of Hepatocellular Carcinoma to Gemcitabine By Non-Invasive Radiofrequency Field-Induced Hyperthermia
… previously reported synergy between gemcitabine and hyperthermia. We found that hyperthermia degrades and inhibits localization of Mre11 to gemcitabine-stalled replication forks. Furthermore, gemcitabine-treated cells that were also treated with hyperthermia demonstrate a prolonged passage …
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Synthesis of 2,4,6-Substituted Pyrrolo[2,3-d]pyrimidines as Potential Anticancer Agents
… focuses on the introduction of the background and work have been done in the areas of antifolates development, such as folate function, its three uptake mechanisms inside human cells, antifolates’ role in chemotherapy, <em>et. al</em>. In addition, the Structure-Activity-Relationship design …
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The Regulation of Dna Methylation In Mammalian Development and Cancer
… maintenance of chromosomal structure and genomic stability, genomic imprinting, retrotransposon silencing, and X-chromosome inactivation. Dysregulation of DNA methylation is associated with various human diseases. For example, cancer cells usually show global hypomethylation and …
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Design, Synthesis and Development of Transporter Targeting Agents For Image-Guided Therapy and Drug Delivery
… purpose of this study was to design, synthesize and develop novel transporter targeting agents for image-guided therapy and drug delivery. Two novel agents, N4-guanine (N4amG) and glycopeptide (GP) were synthesized for tumor cell proliferation assessment and cancer theranostic platform, …
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Cellular Responses in ESCHERICHIA COLI to Lethal and Sublethal Doses of Ozone
… the mechanism by which ozone causes cell damage and eventual cell death we conducted a comprehensive study using <em>Escherichia coli</em> K-12 as a model.</p> <p>Studies on the comparative inactivation of bacteriophage lambda (λ), <em>Escherichia coli</em>, and <em>Candida albicans</em> showed …
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Great Expectations: Phosph(On)Ate Prodrugs In Drug Design—Opportunities and Limitations
<p>Phosphate and phosphonates are chemical moieties with historical precedence in anticancer and antiviral nucleotide analogues. Synchronous to modern efforts identifying novel therapeutic targets in cancer, such chemical moieties are being investigated in the design of novel inhibitors with …
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Amphiphilic Cell-Penetrating Peptides Containing Natural and Unnatural Amino Acids as Drug Delivery Tools and Antimicrobial Agents
… arginine as positively charged residues and tryptophan or diphenylalanine as hydrophobic residues were synthesized. The synthesis was accomplished through the Fmoc solid-phase peptide synthesis in the presence of HBTU and DIPEA. The side-chain protected linear peptides were cleaved from …