Global ETD Search
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Showing 1 to 3 of 3 for “"Nucleic Acid Modifications"”.
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Nucleic acid modifications in bacterial pathogens - impact on pathogenesis, diagnosis, and therapy
Nucleic acids are subject to extensive chemical modification by all organisms. These modifications display incredible structural diversity, and some are essential for survival. Intriguingly, several of these modifications are unique to bacteria, including many human pathogens. Given the enormous …
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Chemical and Enzymatic Methods to Detect Chemical Modifications in Nucleic Acids
… all branches of life. DNA and RNA chemical modifications function as a layer of epigenetic information that regulate gene expression. Studies on the chemical reactivity of nucleic acids and the biochemical activity of enzymes that modify nucleic acids have created a biochemical toolbox with …
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Genome-Wide Characterization of the Effects of Nucleic Acid Modifying Enzymes: Cytidine Deaminases and DNA Methylation
… similar genomics tools to two amenable topics in nucleic acid modifications. First, I used mRNA-Seq to attempt to determine the substrate of the orphan cytidine deaminase Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide 2 (APOBEC2). Next, I used whole-genome bisulfite sequencing to …