Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Nucleic Acid Interactions"”.
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Image Deconvolution Techniques for Single Molecule Studies
… of biophysics, particularly that of protein-nucleic acid interactions, is the need to analyze information from single proteins as opposed to ensembles of many molecules. Consequently, the advent of high-resolution imaging in single molecule microscopy has enabled researchers to probe the …
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Dynamic Molecular Mechanisms and Drug Design of Important Therapeutic Targets
… ligand binding, protein-protein/membrane/nucleic acid interactions, protein folding and GPCR activation. Additionally, Ligand GaMD (LiGaMD) and Peptide GaMD (Pep-GaMD) methods were further developed to model ligand and peptide binding/unbinding, respectively, through improved enhanced …
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Machine Learning and Optimization Algorithms for Intra- and Intermolecular Interaction Prediction
… prediction of intra- and intermolecular interactions, specifically intra- protein residue-residue interactions and the interaction sites in between proteins and other macromolecules, are critical for understanding numerous biological processes. The existing methods fall short in …
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Chemical synthesis of DNA and RNA containing thio-substituted bases and their post-synthetic modifications
… tools for studies of carcinogenesis, protein or nucleic acid structures and functions, protein-nucleic acid interactions, and for antisense modulation of gene expression. One successful example has been the synthesis and study of oligodeoxynucleotides containing 6-thio-2'-deoxyguanine. …
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Investigation into the mechanism of immature HIV-1 capsid assembly
… of, typically, 1000-<br/>2500 copies of Gag in a nucleic acid-dependent manner, resulting in formation of a<br/>spherical capsid immediately below the host cell membrane. The resulting immature, noninfectious<br/>virions are released from the cell and the viral protease, PR, hydrolyses Gag …
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Characterization and design of hydrogen bonding interactions in oxygen reduction by engineered myoglobins
… or more metalloenzymes or metalloproteins. Metal-nucleic acid interactions are also clinically important in cancer and infection treatment, and are useful in industrial purposes. The relationship between macromolecule and metal can almost be viewed as symbiotic – metals often function at extreme …
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Characterization of protein induced fluorescence enhancement (PIFE): A label-free protein assay with short distance sensitivity
… has been recently widely used for monitoring the interactions between a protein and a nucleic acid. It typically requires a site-specific labeling of the protein, which can be labor-intensive and inefficient. In addition, for common dye pairs, the distance sensitivity of FRET lies only between 3-7 …
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Understanding the physiological role of the small RNA RydC
… shown to stabilize cfa (cyclopropane fatty acid synthase) mRNA, resulting in higher levels of cyclopropane fatty acids in the cell membrane. Here, we show that additional sRNAs, ArrS and CpxQ, also directly regulate cfa post-transcriptionally. RydC and ArrS act through masking an RNase E …
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Hydrothermal synthesis and characterization of carbon dots for enhanced biosensing: A focus on optical properties and DNA interactions
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-12-01