Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Nuclear levels"”.
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Determination of Recoil-Free Fractions From 151Eu Mossbauer Spectra of EuBO3
… of a gamma ray from a nucleus is a result of a nuclear transition from one energy level to another. If the emitting nucleus is not bound in a crystal lattice, some of the transition energy, or the difference in energy of the two nuclear levels, may be imparted to the nucleus as it recoils, much …
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HETEROGENEITY OF LATENCY ESTABLISHMENT IN DIFFERENT HUMAN CD4+ T CELL SUBSETS STIMULATED WITH INTERLEUKIN-15
… we analyzed the cellular distribution of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) transcription factor, which is important for HIV expression, we observed that nuclear levels of NF-κB were lower in naïve compared to the other memory subsets, thus partially …
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Resonant elastic photon scattering from the nuclei 88Sr, 89Y, and 90Zr
Nuclear resonant elastic photon scattering in the N=50 nuclei B8Sr, 89y , 90 and Zr was measured between 5 and 10 MeV excitation energy. Average elastic cross sections for natural targets were measured using tagged photons of resolution 60 to 150 keV and a NaI scintillation detector. Total cross …
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THE ROLE OF TIGHT JUNCTION PROTEIN ZO-2 IN THE NUCLEUS AND ITS LINK TO TRANSCRIPTION FACTORS OF THE SLUG/SNAIL FAMILY
… factor was shown to possess functional nuclear localization signals, nuclear export signal and zinc fingers that are important for DNA binding and nuclear retention. Furthermore, ZO-2 may also influence the sub-cellular localization of this transcription factor, for example in wound …
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Modulation of the NFAT signaling pathway by protein kinase B (PKB) ; a perspective study in the context of thymocyte development and T cell function
… PKB tg CD4+ T cells have a drastically reduced nuclear translocation of NFAT proteins and this is due to a direct interaction between PKB and NFAT. To study whether the negative regulatiopn of NFATs by PKB affects T cell development, we analyzed double tg mice expressing both, a constitutively …
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Development of drug screening assays for identification of new molecules against pancreatic ductal adenocarcinoma
… cellsin vitro, despite it leads to increased YAP nuclear levels. The Hippo pathway is the main inhibitor of YAP. One component of this signaling cascade,Lats1/2, phosphorylates YAP at Serine 127, thereby promoting its cytosolic retention and degradation.In line with YAP nuclear retention after the …
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Redox biology of myeloid leukaemias
… cell lines have been shown to generate increased levels of reactive oxygen species (ROS) and DNA double strand breaks (dsbs). However, the molecular basis of how FLT3-ITD-driven ROS leads to the aggressive form of AML is not clearly understood. Herein, we observe that the majority of H2O2 in …
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Effect of Medicinal Herbal, Panax Notoginseng, on the Fate and Function of Professional Antigen Presenting Cells
… with notoginseng (0-200 ìg/ml). The LPS induced levels of the proinflammatory cytokine TNF-á, as well as the expression of accessory molecules MHC II, CD40 and CD86, were decreased dependent on notoginseng exposure time-points relative to LPS stimulation. LPS induced IL-1â, IL-6 and IL-12 …
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Effect of Medicinal Herbal, Panax Notoginseng, on the Fate and Function of Professional Antigen Presenting Cells
… with notoginseng (0-200 ìg/ml). The LPS induced levels of the proinflammatory cytokine TNF-á, as well as the expression of accessory molecules MHC II, CD40 and CD86, were decreased dependent on notoginseng exposure time-points relative to LPS stimulation. LPS induced IL-1â, IL-6 and IL-12 …
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Not Black and White: BMP Signaling Drives Melanocyte Differentiation Downstream of Stem Cell Activation
… at this blockage point. I found reduced nuclear levels of the master regulator MITF and WNT mediator LEF1. Using WNT mutant mouse models, cell culture systems, and chromatin profiling, I provide evidence demonstrating cooperation of BMP and WNT signaling to trigger complete …
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Proteomic Analyses of HIV-1 Infected T-cells and the Functional Characterization of Cyclophilin B During HIV-1 Infection
… infection perturbs the host cell proteome. The nuclear compartment of cells is critical for HIV replication: integration of viral DNA into the host genome is essential to virus replication and pathogenesis; numerous host transcription factors are required for HIV-1 gene expression; and subtle …
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Monochromator studies of nuclear resonance fluorescence in carbon, silicon, and magnesium
… first experimental studies of isolated energy levels with the aid of the University of Illinois bremsstrahlung monochromator. The studies had as objectives both the development of techniques needed to make the monochromator a better tool for studying nuclear levels and the investigation of the …