Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Nuclear factor-Kappa B (NF-κB)"”.
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ADP-Heptose and Nucleotide Enhancers Drive Fusobacteria-Induced Inflammation
… is associated with diverse inflammatory diseases and cancers, but the underlying molecular mechanisms that drive these associations remain elusive. Here I report studies showing that among commensal bacteria, <em>Fusobacteria</em> are uniquely potent activators of nuclear …
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The vascular and anti-inflammatory activity of Cyanidin-3-Glucoside and its metabolites in human vascular endothelial cells
… by investigating the vascular and anti-inflammatory activity of cyanidin-3-glucoside (C3G), the most abundant anthocyanin in the UK diet, and 11 of its recently identified metabolites (including six synthetic metabolites) at physiological concentrations (0.1 – 10 µM) in a human …
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Regulatory role of phosphatidylinositol 4-phosphate 5-kinases in brain inflammation
… and lipopolysaccharide that are well known inflammatory stimulators. c-Jun N-terminal Kinase, phosphoinositide 3-kinase/Akt and extracellular signal-regulated kinase signaling pathways were responsible for the upregulation of PIP5KIα and PIP5KIγ. In addition, we have examined whether gene …
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Epidermal growth factor-mediated activation of the unliganded glucocorticoid receptor in A549 cells
… the regulatory effects of epidermal growth factor (EGF) on cytokine gene expression in order to determine whether previously published examples of EGF repressing the expression of interleukin 6 (IL-6) mRNA occur in other cell types and whether the effects of EGF are mediated via the GR. This …
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Systematic Interrogation of the Stiffness-sensitive Transcriptome in Mesenchymal Stromal Cells Reveals an Immunomodulatory LncRNA CYTOR
… investigated. An understanding of the pertinent factors involved would not only aid in the rational design of substrates but also uncover targetable mechanisms that can facilitate the engineering of MSCs for cell therapies. Here, a bone marrow-mimetic hydrogel is employed to systematically …
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Unraveling the molecular mechanism underlying ALS-linked astrocyte toxicity for motor neurons
… of signaling pathways identified by bioinformatics in purified embryonic stem cell-derived motor neurons, using both pharmacological and genetic techniques, leading to the discovery that nuclear factor kappa B (NF-κB) is instrumental in the demise of motor neurons exposed to mutant …
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Investigating the Role of Pellin03 in TNF Signalling
Tumor necrosis factor (TNF) is an important modulator of the innate immune system, responsible for the activation of immune cells as well as the removal of damaged cells. Aberrant TNF signalling can cause a number of pathologic conditions. TNF binding to TNF receptor 1 triggers the activation of …
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The role of Poly (ADP-ribose) polymerase in the regulation of innate recognition of immunological receptors expressed on human macrophages.
… from CD14-LPS and TLR4/MD-2 complex activate the nuclear factor kappa B (NF-κB) family of transcription factors and JNK, a member of MAP kinase (MAPK) family. This signaling results in the production of the proinflammatory cytokines such as TNF-α and IL-1β among others. In addition, LPS also …
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The Effects of Aging on Muscle Loss and Nuclear Factor Kappa-B Levels in Rats Fed a Diet Containing Suboptimal Leucine Levels
… loss or prevent the process. The transcription factor, Nuclear Factor Kappa-B (NF-κB), is associated with both catabolic and anabolic pathways of muscle metabolism and may be involved in age-related muscle loss. Leucine is an essential amino acid that is required for both protein synthesis and …
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Functions of The Homeobox Gene Dlx4 In Controlling Inflammatory Signaling and Metastasis of Epithelial Ovarian Cancer
… with disease that has disseminated beyond the confines of the ovaries. The five year survival rate for patients with advanced stage EOC is less than 30% and the recurrence of chemoresistant disease is high. Identifying the mechanisms that control peritoneal metastasis of EOC is therefore critical …
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Enzymatic Disassembly of Promoter Bound 7SK snRNP Drives Transcription Elongation of HIV and Cellular Genes
… elongation after inducible transcription factors (TF’s) recruit the P-TEFb kinase to phosphorylate Pol II in response to stimuli. To ensure tight regulation of this process, the majority of P-TEFb is held in a catalytically inactive form, reversibly bound to the 7SK small nuclear …
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Role of the IKKβ/NF-κB pathway in alcoholism
Pro-inflammatory neuroimmune signaling pathways are implicated in the acute and chronic effects of alcohol exposure. Genetic association studies in humans, gene expression microarray studies in postmortem brains of alcoholics, transcriptome meta-analysis in rodents, and drinking models in mice …
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Cannabinoid Type 2 Receptors Promote Cadherin Switching While Suppressing Cell Migration: A Novel Investigation into Biased GPCR Signaling
… and downstream gene regulation mediated by nuclear factor kappa B (NF-κB). Importantly, cannabinoid type 1 (CB1) receptors have been implicated in this novel biased signaling pathway. Therefore, the present study aimed to investigate whether CB2 GPCRs are similarly involved in the proposed …
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Digestible methionine + cysteine:digestible lysine ratio in diets for broilers submitted to inflammatory challenge
… or not to lipopolysaccharides (LPS) (E. coli) inflammatory challenge, 384 thirteen-day-old male chickens were distributed in a 4 x 2 (four ratios x with or without challenge) factorial completely randomized design, with eight replicates per treatment and six chickens per experimental unit (EU). …
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Computer-aided drug design and the biological evaluation of anti-cancer drugs
… quinazoline, a potent inhibitor of the Nuclear Factor kappa B (NF-κB), a transcription factor that has a pivotal role in cancer survival and Pentamidine, an anti-parasitic drug that has recently been demonstrated to possess tumour-killing activity. A hierarchical methodology consisting …
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STAT3, NF-κB, and Estrogen Receptor Beta: The Balance of Inflammation in K-ras Mutant Lung Adenocarcinoma
… cancer subtype in which chronic inflammation pervades the tumor immune microenvironment (TIME). Pro-inflammatory pathways dampen the response to treatments, including immune checkpoint inhibitors, necessitating therapies that target this inflammatory signaling network in the TIME. …
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Mitochondrial Regulation of Arterial Contractility
… or mitoROS generation. ET–1 stimulated nuclear translocation of nuclear factor kappa B (NF–κB) p50 subunit and ET–1–induced IP<sub>3</sub>R–mediated mitoROS elevated NF–κB–dependent transcriptional activity. ET–1 elevated voltage–dependent Ca<sup>2+</sup> (Ca<sub>V</sub>1.2) channel …
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An In Vitro Assessment of The Potential for Engineered Nanoparticles to Modulate Innate Immunity
… surface area and increased solubility) may also influence their ability to modulate immune defense and inflammatory responses in humans. Specifically, recognition of ENPs by Toll-Like Receptors (TLRs) may trigger an innate immune response through activation of the Nuclear Factor-kappa B (NF- κB) …
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Anti-inflammatory and joint-protective effects of blueberries in a monosodium iodoacetate (MIA) induced rat model of osteoarthritis
… project was to investigate the anti-inflammatory and joint-protective effects of blueberries and its polyphenols using an in vitro and in vivo study design. The in vitro design used rabbit synoviocytes stimulated with tumor necrosis factor alpha (TNFα). Rabbit synoviocytes (HIG-82) …
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The role of sphingosine kinases and dihydroceramide desaturase in cell survival/apoptosis and inflammation pathways
… the role of SK1 and SK2 in regulating inflammation-based transcriptional factors in keratinocytes was investigated using western protein analysis of protein expression and luciferase reporter assays. SK2 inhibitors, such as ABC294640 or SKi or K145 or (R)-methylether FTY720 (ROMe) were …
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