Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 244 for “"Nuclear factor"”.
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Nuclear Factor Kappa B Pathway and human cancer therapeutics
Cancer is one of the major causes of morbidity in the world. Although the overall survival of cancer has been significantly improved by chemotherapy in the last three decades, the success of cancer chemotherapy is still severely limited by the lack of selectivity of anti-cancer drugs to malignant …
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Regulation of BACE1 promoter activity by nuclear factor-kappaB\r\n
… a number of putative NF-kappaB transcription factor binding sites on the rat BACE1 promoter. The effects of NF-kappaB binding to the “primary” NF-kappaB binding site of the BACE1 promoter were stimulatory for activated astrocytic cells and repressive for neuronal cells. Age-associated …
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Regulation of IGFBP-5 and Osteoblast Functions by Nuclear Factor I
The Insulin-like Growth Factor (IGF) system is a major target of GC inhibition in bone. We found that GCs inhibit expression of IGF binding protein-5 (IGFBP5) which binds IGFs and stimulates osteoblast activity by IGF dependent and independent mechanisms. GC-induced inhibition of IGFPB5 promoter …
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Sumo and Ubiquitin Ligases Regulate Hepatocyte Nuclear Factor - 1 Beta Transcriptional Activity
Hepatocyte nuclear factor-1beta (HNF-1β ) is a homeodomain-containing transcription factor that regulates tissue-specific gene expression in the kidney, liver, and other organs. Humans with heterozygous mutations of HNF-1β develop maturity-onset diabetes of the young type 5 (MODY5) associated with …
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Functional characterization and regulation of liver transcription factors hepatocyte nuclear factor 3.
… and regulation of liver transcription factors hepatocyte nuclear factor 3.
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Cerebrovascular and Neuronal Cellular Consequences of Amyloid-β Induced Nuclear Factor-κB Activation
… significant role in inflammatory responses, the nuclear factor-κB (NF-κB) pathway is hypothesized to play such a regulatory function in AD.</p> <p>The work presented here examines the cellular activation of NF-κB by Aβ aggregates in both cerebrovascular and neuronal cells. Small Aβ aggregates …
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Role of nuclear factor kappa B (NFkB) in the vascular complications of diabetes.
… was investigated. Specifically, the role of nuclear factor kappa B1 (NFĸB1). There were 2 approaches used in this study: i) a bioinformatics approach to determine what single nucleotide polymorphisms (SNP) may occur within the NFĸB1 gene in T2DM and ii) a molecular biology approach to …
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FUNCTIONAL STUDY OF THE NONCODING REGULOME OF THE NUCLEAR FACTOR Y IN HUMAN CANCER
… Ci siamo concentrati sul fattore di trascrizione nucleare Y (NF-Y), che ha un ruolo nella regolazione della proliferazione in cellule normali e tumorali. Dato che il suo ruolo fisiologico e il suo coinvolgimento nel cancro sono noti, ci siamo focalizzati sullo studio della regolazione …
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Characterization of Genome-Wide Binding of NUCLEAR-FACTOR I-X in Hematopoietic Progenitor Cells
… other well-known hematopoietic transcription factors, including pSTAT1, RUNX1, RAD21, STAT3, ETO2, FLI1, GATA2, LYL1, LDB1 and PU.1. We showed NFIX and PU.1 together target genes regulating hematopoietic cell adhesion, cell death and differentiation in hematopoietic cells. Our data support a …
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An agent-based model of the IL-1 stimulated nuclear factor-kappa B signalling pathway
The transcription factor NF-κB is a biological component that is central to the regulation of genes involved in the innate immune system. Dysregulation of the pathway is known to be involved in a large number of inflammatory diseases. Although considerable research has been performed since its …
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Analysis of the role of nuclear factor-kappa B in insulin resistance caused by antiretroviral drugs
Human immunodeficiency virus still remains the leading cause of death globally including women of child-bearing age. The rate of AIDS-related death has significantly declined since the introduction of antiretroviral treatment and other non-medical interventions such as the distribution and use of …
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AP2IX-4, a Cell Cycle Regulated Nuclear Factor, Modulates Gene Expression During Bradyzoite Development in Toxoplasma Gondii
… cyst formation. The major class of transcription factor likely to work through these cis-regulatory elements appears to be related to the Apetala-2 (AP2) family in plants. The Toxoplasma genome contains nearly 70 proteins harboring at least one predicted AP2 domain, but to date only three of these …
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Germ cell nuclear factor is not required for the down-regulation of pluripotency markers in fetal ovarian germ cells
… particular timing, nor is it understood what factors are involved in their repression. I have examined in fetal ovarian germ cells the expression and function of Gcnf (germ cell nuclear factor), an orphan nuclear receptor known to regulate both Oct4 and Nanog in gastrulating embryos. I have …
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Regulation of the Nuclear Factor of Activated T Cell (NFAT) Family of Transcription Factors in the Freeze Tolerant Wood Frog, Rana sylvatica
… partially mediated by transcription factor control over gene expression. Here, involvement of the nuclear factor of activated T-cells (NFAT) transcription factors, isoforms c1-c4, was analyzed in liver and skeletal muscle over freeze/thaw and anoxia/re-oxygenation cycles. Freezing …
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The Effects of Aging on Muscle Loss and Nuclear Factor Kappa-B Levels in Rats Fed a Diet Containing Suboptimal Leucine Levels
… loss or prevent the process. The transcription factor, Nuclear Factor Kappa-B (NF-κB), is associated with both catabolic and anabolic pathways of muscle metabolism and may be involved in age-related muscle loss. Leucine is an essential amino acid that is required for both protein synthesis and …
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The in vitro effects of diallyl trisulfide on osteoclast formation and function in RAW 264.7 murine macrophages
… bone degeneration. When the receptor activator nuclear factor-kappa B ligand (RANKL) interacts with the receptor activator nuclear factor-kappa B (RANK), found on osteoclast precursors, precursors of osteoclasts develop into mature osteoclasts. Reactive oxygen species (ROS), nuclear factor kappa …
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