Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Nuclear deformation"”.
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NUCLEAR DEFORMATION IN FISSION FRAGMENTS STUDIED WITH NOVEL IMPLEMENTATIONS OF DOPPLER SHIFT LIFETIME MEASUREMENT TECHNIQUES
… The latter can have sizable de- viation (i.e., deformation) with respect to the spherical shape. Nuclear deformation is found especially far from the magic numbers of nuclear stability. The evolution of nuclear shapes in different regions of the nuclear chart is the subject of extensive studies, …
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Novel roles of ADF/cofilins in maintenance of homeostasis in normal and malignant epithelial cells
… of the tissue, actin filament accumulation and nuclear deformation. Loss of ADF/CFL1 in cultured malignant keratinocytes also led to aberrant cell morphology accompanied by unrestrained accumulation of actin stress fibers tethered to enlarged focal adhesions. Enhanced SRF/MAL-mediated …
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INVESTIGATING THE ROLE OF LIPID DROPLETS AS INTRACELLULAR MECHANICAL STRESSORS IN NON-ALCOHOLIC FATTY LIVER DISEASE
… mechanical stressors, associated with nuclear deformation, chromatin condensation, and impaired hepatocyte function (Chapter 3). We found that lipid accumulation disrupts normal cytoskeletal network organization, reducing cell traction forces and preventing proper stiffness sensing. …
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Multiscale Modeling of Genome Organization: Bridging Polymer Physics, Molecular Dynamics, and AI
… apply computational frameworks to investigate nuclear genome organization at high spatial and temporal resolution. Our approaches integrate biophysical modeling and generative artificial intelligence to address complementary aspects of nuclear architecture. In Chapter 1, we provide an overview …
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INTRACELLULAR FORCES AND NUCLEAR MECHANOBIOLOGY DURING CONFINED CELL MIGRATION IN 3-DIMENSIONS
… cells apply sufficient force to complete this deformation of the nucleus through constrictions. Here, we established a microfluidic platform for studying nuclear deformation through precisely defined constrictions. Using this platform, we demonstrate evidence of a novel mechanism by which cells …
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The Impact of substrate texture on cell behavior
… measurements showed that the cell thickness and nuclear shape is regulated through the different arrangement of perinuclear actin stress fibers depending on the stripe sizes. We also observed that when the size of stripes (5 µm) is significantly smaller than the size of cell nuclei (subnuclear …