Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Nuclear body"”.
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Analysis of the Role of Akirin Interactions with Nuclear Body Proteins During Myogenesis
<p>Akirin is a highly conserved, small nuclear protein of indeterminate structure ubiquitously expressed in non-fungal eukaryotic species. It was first discovered in the innate immune response, but many other functions have since been found, including embryonic muscle patterning and myogenesis. …
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Modelling Nuclear Body Dynamics in Living Cells by 4-D Microscopy, Image Analysis and Simulation
… demonstrates rules of and validates models for nuclear body (NB) dynamics. Simulation tools developed in the course of this work can be used in future work to generate hypotheses about related aspects of nuclear architecture. Initially I examined the mobility of vimentin nuclear bodies bodies …
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Observations on division, nuclear-body-size relation and mitosis of the common marine Ameba ; Flabellula citata
Thesis (M.A.)--University of Kansas, Zoology, 1926.
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Organization principles of the early Drosophila embryo
… fly Drosophila melanogaster: the Histone Locus Body size control and cortical migration of nuclei. The Histone Locus Body (HLB) is an evolutionarily conserved nuclear body that regulates the transcription and processing of histone mRNAs. We show that Drosophila HLBs form through phase …
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Novel Single Cell Methods to Identify the Genetic Composition at a Single Nuclear Structure
… or the ligation of oligo probes to subnuclear sites of double stranded breaks induced by 2-photon irradiation. It is demonstrated that these techniques afford the ability to identify loci occupying a shared site at a single nuclear substructure, and are thus uniquely suited for …
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Engineering a synthetic p53-Mdm2 network in budding yeast
… the co-localization of p53 and Mdm2 to a nuclear body reminiscent of human PML bodies. In conclusion, attempting to rebuild from scratch a simplified version of the intricate p53 network, isolating it from its natural context, has proven to be a very powerful means leading to unexpected …
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RNA in the nucleus: insight into location and biological function
… the top caRNAs identified by MARGI were several nuclear body associated RNAs including SNHG1, MALAT1, NEAT1 and XIST. 80 – 95% of the DNA targets of caRNA were observed to be connected to the loci of RNA transcription, 1-2% were observed to be on the same chromosome but distal to the loci of RNA …
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Data-driven Mechanistic Modeling of 3D Human Genome
… biological processes, such as the coalescence of nuclear bodies. This thesis is organized as follows. In the first chapter, we introduce a computational model to simulate chromatin structure and dynamics. The model defines chromatin states by taking one-dimensional genomics and epigenomics data as …
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Genomic and microscopic dissection of nuclear compartmentalization and function
… for gene expression regulation. Abnormal nuclear organization is related to disease. Microscopy measurements of individual genes reveal a population-based, statistical gradient of increased gene activity from the nuclear periphery to the center. Sequencing-based methods (Hi-C, DamID) …