Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Nuclear Targeting"”.
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Design of Nuclear-Targeting Peptides for Macromolecule Delivery via Machine Learning
The effective design of functional peptide sequences remains a fundamental challenge in biomedicine. For example, cell-penetrating peptides (CPPs) are capable of delivering macromolecular cargo to intracellular targets that are otherwise inaccessible. However, design of novel CPPs with high …
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Effect of rare and common single amino acid substitutions on DISC1 subcellular targeting and functional interaction with ATF4
… amino acid substitutions on DISC1 subcellular targeting, establishing that the rare mutation R37W and the common variant L607F disrupt DISC1 nuclear targeting in a dominant-negative fashion. This finding predicts that DISC1 nuclear expression is severely impaired in 37W and 607F carriers. In …
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Solid Phase Synthesis and Biological studies on metal conjugates of bioactive peptides for targeted delivery
… affinities, efficient cellular uptake and/or nuclear targeting. Thus, in this research project, metal conjugates of some bioactive peptides were synthesized and biologically tested in order to evaluate the effects of these metal moieties on the biological activities such as the cellular …
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Modulatable endosomalytic, intracellularly biodegradable vectors for gene delivery
… reduction and are non-toxic to cells. The nuclear targeting signal (TAT) was incorporated into these vectors. The reducible copolycations (RcPCs) were synthesized via oxidative polymerisation between 2COPs and TAT. The RcPC polyplexes are ~100 nm, and are positively charged. Gel shift assay …
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The most dangerous game : a phenomenological criticism of the rhetoric of nuclear war, 1945-1981.
… policy rhetors in the specific instance of nuclear diplomacy rhetoric. This group of speeches is argued to be particularly rich in such appeals for two primary reasons. First, the nature of nuclear conflict is such that Presidents will seek acceptance of their policies without meaningful …
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Nuclear-Targeted Gold Nanoparticles Enhance The Effects of Radiation Therapy With and Without Liposomal Delivery
… to effective particle distribution for DNA-targeting.</p> <p>Clinical translation of radiosensitizing nanoparticles has stalled owing to technical challenges. Current strategies to use AuNPs for radiosensitization require large quantities of gold, kilovoltage x-rays, immediate irradiation …
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Quantitative Analysis of the Structural Dynamics of Mitotic Chromosomes in Live Mammalian Cells
… strongly suggesting a function in post-mitotic nuclear assembly and architecture. In addition, if anaphase compaction was perturbed in condensin-depleted cells, segregation defects increased 3-fold, suggesting a second role for anaphase compaction as a rescue mechanism for segregation defects. …
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Nuclear Localization of Proteins and Genome Editing in the Oomycete Phytophthora sojae
… of the most important intracellular activities, nuclear localization of proteins, and describe the characterization of nuclear localization signals (NLSs) in P. sojae. This focus stemmed from my early work on genome editing in P. sojae, when I discovered that conventional NLS signals from SV40 …
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Analysis and suppression of mutant sel-12 in Caenorhabditis elegans
… from the membrane. This step is crucial for nuclear Notch signaling. As a consequence, loss of all presenilin activity, in a sel-12; hop-1 double mutant, causes phenotypes associated with the complete absence of all Notch signaling in C. elegans. Loss of sel-12 function in C. elegans leads to …
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Developmental and Cellular Functions of Delta-Catenin
… G proteins.</p> <p>In examining delta-catenin’s nuclear roles, I identified delta-catenin as an interacting partner and substrate of the caspase-3 protease, which plays critical roles in apoptotic as well as non-apoptotic processes. Delta-catenin’s interaction with and sensitivity to caspase-3 …
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Discovery of Molecules that Modulate Protein-Protein Interactions in the Context of Human Proliferating Cell Nuclear Antigen-Associated Processes of DNA Replication and Damage Repair
… homotrimeric protein complex Proliferating Cell Nuclear Antigen (PCNA) that encircles chromatin-bound DNA and functionally acts as a DNA clamp that provides topological sites for recruitment of proteins necessary for DNA replication and damage repair. PCNA has critical roles in the survival and …
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Purification of protein phosphatases and 14-3-3-binding proteins and their regulation by the cAMP–PKA pathway
… of the pathway with H-89. R6 is a glycogentargeting subunit of PP1 while glycogenin acts as the primer during glycogen synthesis; these glycogen moieties are then elongated by glycogen synthase. We think the enrichment of glycogen synthase and glycogenin from PP1 immunoprecipitates treated …