Global ETD Search
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Showing 1 to 1 of 1 for “"Nuclear Receptor Subfamily 4, Group A, Member 1"”.
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Nur77 Prevents Excessive Osteoclastogenesis by Inducing Ubiquitin Ligase Cbl-b to Mediate NFATc1 Self-Limitation
… uncover a novel and critical role of the orphan nuclear receptor Nur77 in mediating an NFATc1 self-limiting regulatory loop to prevent excessive osteoclastogenesis. Nur77 deletion leads to low bone mass owing to augmented osteoclast differentiation and bone resorption. Mechanistically, NFATc1 …