Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 114 for “"Nuclear Receptor"”.
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Nuclear receptor co-repressor actions in bladder cancer
Nuclear receptors (NR) are ligand dependent transcription factors. In the current study, expression of VDR and Farnesoid-X-receptor (FXR) protein is demonstrated along with relative mRNA expression of a range NRs and co-repressors in four bladder cancer cell lines. Nuclear co-repressor 1 (NCoR1) is …
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The Role of Coregulator Proteins in Nuclear Receptor Transcriptional Activity
… characterized a novel DEAD box RNA helicase as a nuclear receptor coregulator. I have also examined the similarities in the actions of ERalpha and ERbeta using large-scale chromatin arrays and ER subtype-selective ligands.
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Developmental Characterization of Cara Mitad: A Drosophila Nuclear Receptor Co-Regulator
… events that guide proper development. Nuclear receptors (NR) respond to these hormone signals by activating cascades of gene expression, along with coregulator protein complexes. In Drosophila melanogaster, fluctuating titers of the steroid hormone ecdysone are responsible for …
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Intracellular Lipid Surveillance Through Interplay Between a Nuclear Receptor and Rab GTPases
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Regulation of Bile Acid Biosynthesis by Orphan Nuclear Receptor Small Heterodimer Partner
These combined studies should greatly advance our understanding of how bile acid biosynthesis is regulated in both SHP-dependent and SHP-independent pathways. Importantly, these studies for the first time demonstrate that SHP has a short half-life of 20 to 30 minutes. Bile acids and FGF15/19 …
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Regulation of oligodendrocyte lineage cell function by the RXR$\gamma$ nuclear receptor
… regenerative potential is compromised. The nuclear receptor RXR$\gamma$ is an important positive regulator of OPC differentiation and an accelerator of endogenous remyelination in aged rats. RXR$\gamma$ functions as a ligand-induced transcription factor and is able to regulate gene …
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Nuclear Receptor Controls Nematode Metabolism And Development: Insight Into Man’s Nemesis, the Conqueror Worm
The nuclear receptor DAF-12 plays a central role in controlling the larval development of C. elegans. Activation of DAF-12 by its ligands called dafachronic acids (DAs) commits the nematode to development into reproductive adult, which will otherwise arrest at a diapause stage called dauer. But the …
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The Roles of Nuclear Receptor NR4A1 in Cancer Cell Proliferation and Skeletal Muscle Differentiation
<p> Nuclear receptors (NRs) constitute a major class of drug targets in the treatment of various cancer types. NRs respond to cellular signals and become activated upon ligand binding to transcriptionally modulate expression of target genes. NR4A1 (Nur77) is a member of the NR4A family of nuclear …
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Fatty acid ethanolamides pinpoint nicotinic receptors and modulate neuronal excitability through nuclear receptor PPARα
… through the peroxisome-proliferator-activated receptor-α (PPARα) and to elucidate their mechanism of action in an in vitro brain slice preparation. 2) To determine whether there is an interaction between PPARα and nAChRs in VTA DA cells: particularly, to characterize the postsynaptic effects of …
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Metabolic regulation by nuclear receptor FXR and micro RNA-34a in health and disease
… I explored the function role of Farnesoid X receptor (FXR) and microRNA-34 (miR-34a), as key transcriptional and post-transcriptional regulators respectively, in maintaining metabolic hemostasis and energy balance. Nuclear receptors (NRs) are lipophilic ligand-dependent transcriptional …
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INHIBITING THE NUCLEAR RECEPTOR ESRRA RESCUES CORE PATHOLOGIES IN CELLULAR AND ANIMAL MODELS OF BATTEN DISEASE
… on the top candidate hit, Estrogen-related receptor alpha (ESRRA/ESRRA), a nuclear receptor involved in mitochondrial biogenesis, lipid metabolism, and autophagy. Both genetic silencing and pharmacological inhibition of ESRRA with the inverse agonist XCT-790 significantly reduced Gb3 …
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Nuclear receptor co-repressor functions in prostate cancer; in vitro, in vivo and in silico approaches
… epithelial cells are exquisitely sensitive to Nuclear Receptor (NR) ligands. These compounds exert anti-proliferative effect over non-malignant cells RWPE-1 while malignant PC-3 cells retain their proliferative ability. The Nuclear Receptor Co-Repressor 1 (NCOR1) complexes with Histone …
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Exploration of Nuclear Receptor Activity and siRNA-Derived Phenotypes as Therapeutics in Non-Small Cell Lung Cancer
Nuclear hormone receptors are master regulators of diverse cellular functions implicated in tumor pathogenesis and as oncogenic drivers of many human cancers. To better understand what role these important receptors might be playing in lung cancer, three interconnected studies were initiated to …
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The role of orphan nuclear receptor DAX-1 (NR0B1) in human breast cancer cells: expression, proliferation and metastasis
<p>The orphan nuclear hormone receptor DAX-1 (Dosage Sensitive Sex Reversal, Adrenal Hypoplasia Congenita on the X Chromosome, gene 1) plays an important role in the development of adrenal and gonadal tissues and functions as a global negative-regulator of steroidogenesis. In addition, it is known …
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Nuclear receptor TLX and dietary habits: Identifying new targets for the treatment and prevention of metastatic breast cancer
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-12-01
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Identification of Ligands for the Orphan Nuclear Receptor DAF-12 That Govern Dauer Formation and Reproduction in C. Elegans
The orphan nuclear hormone receptor, DAF-12, plays a central role in the physiology of free-living nematode, C. elegans. DAF-12 is best known for its role in regulating dauer formation, a non-reproductive larval state entered in harsh environments and marked by developmental arrest, stress …
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Regulation of proliferation, apoptosis, and metastasis in prostate cancer cells by DAX-1 (NR0B1)- an androgen-induced orphan nuclear receptor
… gene 1) is an unusual member of the Nuclear Hormone Receptor superfamily that has the ability to interact with other Nuclear Receptors (NRs) and transcriptional co-repressors and co-activators. While DAX-1 plays an important role in adrenal and gonadal development, recent studies have …
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The role of microRNA-802 regulated by the nuclear receptor FXR-SHP cascade in obesity and non-alcoholic fatty liver disease
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-12-01
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A four-and-a-half LIM protein FHL2 acts as a coactivator for the Wilms' tumor suppressor WT1 during gonadal differentiation
… The Wilms' tumor suppressor (WT1) and the orphan nuclear receptor steroidogenic factor 1 (SF-1) bind cooperatively to the promoter of MIS and activate its transcription. In the ovary, on the other hand, the orphan nuclear receptor DAX-1 binds to SF-1. The binding inhibits WT1/SF-1 transactivation …
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