Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Nuclear Matrix"”.
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Isolation and characterization of a common nuclear matrix protein and other studies
The nuclear matrix, the RNA-protein skeleton of the nucleus, is known to play functional and structural roles within the cell. My thesis investigated the roles of the nuclear matrix proteins under various circumstances. First, the rat prostate cancer cell line (MLL) was injected into various sites …
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The Association of the Human Cytomegalovirus Genome with the Cellular Nuclear Matrix
… its capability of fulfilling criteria defining nuclear scaffold/matrix attachment regions (S/MARs). These criteria are: 1) binding the nuclear matrix in an in vitro nuclear matrix binding assay; 2) binding the nuclear scaffold in an in situ nuclear scaffold binding assay; and 3) activating …
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The association of bovine parvovirus DNA and proteins with the nuclear matrix of infected cells
Bovine parvovirus DNA is associated with the nuclear matrix of infected bovine fetal lung cells as shown by Southern blot analysis of matrix DNA isolated by two procedures differing in the order of exposure of detergent-treated nuclei to high salt conditions and DNase I. Protein analysis of the two …
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The roles of nuclear matrix protein 4 and high mobility group box 1 in mediating the osteoblast response to anabolic agents
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Characterization of the Drosophila Scaffold Attachment Factor B (SAFB)
… domains, which are fixed at their bases to the nuclear matrix or scaffold. SAFB has been identified as a nuclear matrix binding protein in humans. Human SAFBs contain an N-terminal DNA-binding SAP-Box, and an RNA recognition motif (RRM). However it is unknown how the features of SAFB are linked …
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Heavy-ion double charge exchange reactions as tools for 0bb decays. The 40Ca(18O,18Ne)40Ar reaction at 270 MeV by using MAGNEX
… in a research line that aims to access the Nuclear Matrix Element (NME) involved in the half-life of the 0 bb decay, by measuring the cross sections of heavy-ion induced Double Charge Exchange (DCE) reactions with high accuracy. The basic point is that the initial and nal state of both 0 bb …
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Identification and functional characterization of the novel MAR-binding protein, SATB2
… complex. In addition to enhancers and promoters, nuclear matrix attachment regions (MARs) have been implicated in the regulation of gene expression by altering the organization of eukaryotic chromosomes and augmenting the potential of enhancers to act over large distances. Although a lot is known …
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Probing the Frontiers of the Standard Model with Lattice QCD
… of experimental results depend on nuclear matrix elements of the isotopes in question. This work describes the first exploratory lattice QCD calculation of this nuclear matrix element for the nn --> ppee transition. In all these cases, lattice QCD provides the necessary theoretical …
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Nmp4 restricts bone marrow osteoprogenitors and parathyroid hormone induced bone formation in healthy and estrogen depleted female mice
We have shown that nuclear matrix protein 4 (Nmp4) attenuates the response to intermittent parathyroid hormone (PTH) in healthy and ovariectomized (OVX) female mice using a global knockout of the Nmp4 gene. Additionally, these mice have increased bone marrow osteoprogenitors and CD8+ T-cells which …
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First Step into A New Physics Realm: Search for the Majorana Nature of Neutrinos in the Inverted Mass Ordering Region
… theoretical calculation of the non-perturbative nuclear matrix element for 0𝜈𝛽𝛽 is done using lattice quantum chromodynamics (LQCD) to interpret the experimental data. The preliminary results of 𝑛⁰𝑛⁰ → 𝑝⁺𝑝⁺𝑒⁻𝑒⁻ process for both long-range (light Majorana neutrino exchange) and short-range (heavy …
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Double-Beta Decay of 96Zr and Double-Electron Capture of 156Dy to Excited Final States
… experimental searches for second-order weak nuclear decays to excited final states were conducted. Both experiments were carried out at the Kimballton Underground Research Facility to provide shielding from cosmic rays. The first search is for the two-neutrino double-beta decay of 96Zr to …
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Measurement of the double beta decay half-life of ^{100}Mo to the 0^{+}_{1} excited state, and ^{48}Ca to the ground state in the NEMO 3 experiment
… for not only particle physics, but also nuclear physics, astrophysics and cosmology. The study of two-neutrino double beta decay gives us a better understanding of the nuclear models used to calculate the nuclear matrix elements, which are so important in extracting new physics parameters …
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Experimental and theoretical multi-channel study of direct nuclear reactions: a tool to provide data driven information on neutrino-less double-beta decay
… aims to provide experimental information on the nuclear matrix elements involved in the expression of 0vbb-decay half-life by measuring the cross-section of double charge exchange nuclear reactions. The experimental set-up to measure the zero-degrees double charge exchange nuclear reaction …
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The genomic anchors of the human major histocompatibility complex
… of topologically constrained loop structures. Matrix Attachment Regions (MARs) are genomic sequences that mediate the anchoring of chromatin to the insoluble proteinaceous fraction of the nucleus known as the nuclear matrix. Since only a few MARs have been characterised so far, their role in …
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Modulation of lineage-specific cell differentiation by long non-coding RNAs
… that EC6 is retained in chromatin and binds the nuclear matrix factor hnRNP U, which may enable co-localization with its targets to mediate their repression. Extending our work to a different lineage, we reconstructed transcriptomes from distinct mouse adipose tissues and identified ~1500 …
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Novel plant nuclear envelope-associated coiled-coil proteins
The nuclear envelope (NE) is a double lipid bilayer enclosing the eukaryotic genome. The metazoan nucleoskeleton includes the peripheral lamina and the internal nucleoskeleton. The lamina is composed of a network of intermediate filament (IF) proteins called lamins, as well as lamin- and/or …
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Dynamics of human DNA Topoisomerases I and II
… considered to be a structural component of the nuclear matrix and the chromosome scaffold. We must conclude that if this was the case, then these architectural structures appear to be much more dynamic than believed until now. In this context it should also be mentioned, that the alignment of …
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Characterisation of the multi-isomeric protein nesprin-1 in p-body and mRNA dynamics
Nuclear envelope spectrin repeat proteins, or Nesprins, are a novel family of nuclear and cytoskeletal proteins with rapidly expanding roles as intracellular scaffolds and linkers. Nesprins are characterized by a central spectrin repeat (SR) rod domain and a C-terminal KASH domain, which acts as a …
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Attenuation of the scintillation light in liquid argon and investigation of the double beta decay of ⁷⁶Ge into excited states of ⁷⁶Se in the GERDA experiment
… with the half life of the 0𝜈𝛽𝛽 decay via a nuclear matrix element (NME), which is predicted by various theoretical models that are afflicted by large uncertainties. The accuracy of the different NMEs and their internal model assumptions can be increased by considering experimental …
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