Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Nuclear Factor-kappaB"”.
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Regulation of BACE1 promoter activity by nuclear factor-kappaB\r\n
… the generation of beta-amyloid peptides. The NF-kappaB binding DNA consensus sequence in the BACE1 promoter upstream of the gene’s transcription start site suggests a role for NF-kappaB in the expression of neuronal brain BACE1. Failure of activation of NF-kappaB responses to stress in the aged …
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Phosphatidylinositol 4-phosphate 5-kinase Involved in Neuroglial Toll-like Receptor Signaling
… protein kinase, c-Jun N-terminal kinase, and nuclear factor-kappa B (NF-kappaB) p65, and degradation of inhibitor kappaB-alpha. Consistent with these, transcriptional activity of nuclear factor-kappaB was reduced by the PIP5K-alpha knockdown. Complementation of the PIP5K-alpha knockdown cells …
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The Role of Lipoprotein(a)/Apolipoprotein(a) in Endothelial Dysfunction: Mechanistic Studies in Vascular Endothelium
… (Lp(a)) concentrations are a significant risk factor for the development of a number of vascular diseases including coronary heart disease and stroke. Lp(a) consists of a low-density lipoprotein (LDL)-like moiety and an unique glycoprotein, apolipoprotein(a) (apo(a)), that is covalently …
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Role of the NF-kappaB-HIF Crosstalk in Inflammation and Hypoxia
… to hypoxia in the cell is the transcription factor called Hypoxia Inducible Factor (HIF). HIF has recently been associated with a role in inflammation and immunity. Importantly, HIF-1alpha has shown to be regulated by the major inflammatory responsive transcription factor, NF-kappaB (nuclear …
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Haploid reporter screens aimed at identification of NF-kappaB regulators
Nuclear factor-kappaB (NF-KB) is a family of transcription factors that are essential for execution of both the innate and the adaptive immune response. NF-KB regulates hundreds of genes involved in critical processes such as cell survival, differentiation, proliferation, and inflammation. …
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Regulation of Insulin and CHOP Gene Expression in Pancreatic Beta Cells
… However, sumoylation of MafA did not alter its nuclear localization, protein stability, or apparently its DNA binding to the insulin promoter in beta cells. These studies suggest that MafA sumoylation modulates gene transcription in beta cells. In type I diabetes, beta-cell apoptosis is the …
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Microvascular endothelial response to cocaethylene exposure: morphological and molecular observations
… molecule phosphorylation, and transcription factor DNA binding activity (Aims Three and Four). Aim One experiments demonstrated a lack of overt endothelial cytotoxicity caused by CE. Aim Two morphological analysis of endothelial intercellular borders and barrier integrity showed that CE …
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Prevention of Acute Pancreatitis by Broccoli Components
… preventive intervention by early inhibition of nuclear factor-kappaB (NF-kappaB). Cholecystokinin (CCK)-induced acute pancreatitis is the most widely used in vivo experimental model, with a similar inflammation profile to acute pancreatitis in humans. Administration of crambene …
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Identification of a gap junction communication pathway critical in innate immunity
… activation patterns of two key transcription factors in inflammation and innate immunity: Nuclear factor-KappaB (NFKB) and Interferon regulatory factor 3 (IRF3). Stimulation of NFKB-GFP reporters resulted in a spatially homogeneous pattern of activation, found to be largely mediated by …
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PHOSPHORYLATION OF NF-ΚB RELA/P65 ON SER536 SIGNALS CANCER CELLS TO DEATH AND ENHANCES CHEMOSENSITIVITY
RelA/p65 is a main subunit of nuclear factor-kappaB (NF-kappaB) that regulates expression of genes involved in cell growth and survival, stress response, and inflammation, but its oncogenic or tumor-suppressive function in tumorigenesis has been highly controversial. Hundreds of NF-kappaB …
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Exploring a Novel Mechanism of Reguation of the TNFR Family Member FN14
Fibroblast growth factor-inducible 14 (FN14) is a highly inducible cytokine receptor linked to a number of intracellular signaling pathways, including the nuclear factor-kappaB (NFkB) and mitogen-activated protein kinase (MAPK) pathways, as well as to physiological processes, such as angiogenesis, …
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Repression of Protein Kinase C Delta in Human Squamous Cell Carcinomas by Ras, Fyn and NF-Kappa B Signaling
… PKC-delta promoter activity by activation of nuclear factor kappa B (NF-kB) and recruitment of repressive NF-kB subunits (p50 and c-Rel).</p><p>We also found that Fyn tyrosine kinase activation was necessary and sufficient for NF-kB activation and PKC-delta repression. In addition, Fyn was …