Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 68 for “"Nuclear Factor kappa B"”.
-
Nuclear Factor Kappa B Pathway and human cancer therapeutics
Cancer is one of the major causes of morbidity in the world. Although the overall survival of cancer has been significantly improved by chemotherapy in the last three decades, the success of cancer chemotherapy is still severely limited by the lack of selectivity of anti-cancer drugs to malignant …
-
Role of nuclear factor kappa B (NFkB) in the vascular complications of diabetes.
… was investigated. Specifically, the role of nuclear factor kappa B1 (NFĸB1). There were 2 approaches used in this study: i) a bioinformatics approach to determine what single nucleotide polymorphisms (SNP) may occur within the NFĸB1 gene in T2DM and ii) a molecular biology approach to …
-
An agent-based model of the IL-1 stimulated nuclear factor-kappa B signalling pathway
The transcription factor NF-κB is a biological component that is central to the regulation of genes involved in the innate immune system. Dysregulation of the pathway is known to be involved in a large number of inflammatory diseases. Although considerable research has been performed since its …
-
Analysis of the role of nuclear factor-kappa B in insulin resistance caused by antiretroviral drugs
Human immunodeficiency virus still remains the leading cause of death globally including women of child-bearing age. The rate of AIDS-related death has significantly declined since the introduction of antiretroviral treatment and other non-medical interventions such as the distribution and use of …
-
The Effects of Aging on Muscle Loss and Nuclear Factor Kappa-B Levels in Rats Fed a Diet Containing Suboptimal Leucine Levels
… loss or prevent the process. The transcription factor, Nuclear Factor Kappa-B (NF-κB), is associated with both catabolic and anabolic pathways of muscle metabolism and may be involved in age-related muscle loss. Leucine is an essential amino acid that is required for both protein synthesis and …
-
The in vitro effects of diallyl trisulfide on osteoclast formation and function in RAW 264.7 murine macrophages
… bone degeneration. When the receptor activator nuclear factor-kappa B ligand (RANKL) interacts with the receptor activator nuclear factor-kappa B (RANK), found on osteoclast precursors, precursors of osteoclasts develop into mature osteoclasts. Reactive oxygen species (ROS), nuclear factor kappa …
-
The effects of chrysin on osteoclastogenesis in RAW264.7 murine macrophages and bone metabolism in Sprague Dawley rats
… in bone deterioration. Receptor activator of nuclear factor-kappa B (RANK) signalling is critical for function and formation of osteoclasts. This study aimed to investigate the potential beneficial effects on bone from chrysin, a bioactive phytochemical. Western blotting was carried out to …
-
ADP-Heptose and Nucleotide Enhancers Drive Fusobacteria-Induced Inflammation
… are uniquely potent activators of nuclear factor kappa B (NF-κB) signaling, a pathway implicated in inflammatory diseases and cancers. I found that <em>Fusobacterium</em> <em>nucleatum</em> secretes pathogen-associated molecular pattern ADP-heptose and ribonucleotides that together, …
-
Targeting Cox-2 and Rank In Aggressive Breast Cancers: Inflammatory Breast Cancer and Triple-Negative Breast Cancer
… (COX-2) and receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B (RANKL/RANK) pathway mediate an inflammatory response linked to breast cancer progression. However, the mechanism of how COX-2 and RANKL/RANK regulates the progression of IBC …
-
Targeting Cox-2 and Rank In Aggressive Breast Cancers: Inflammatory Breast Cancer and Triple-Negative Breast Cancer
… (COX-2) and receptor activator of nuclear factor kappa B ligand/receptor activator of nuclear factor kappa B (RANKL/RANK) pathway mediate an inflammatory response linked to breast cancer progression. However, the mechanism of how COX-2 and RANKL/RANK regulates the progression of IBC …
-
The vascular and anti-inflammatory activity of Cyanidin-3-Glucoside and its metabolites in human vascular endothelial cells
… electron paramagnetic resonancespectroscopy, and nuclear factor kappa B (NF-κB) activation was established by flow cytometry. The data indicate that C3G, its A-ring degradant, phloroglucinaldehyde (PGA), and its phase II metabolite vanillic acid (VA) increased the basal expression of endothelial …
-
Effects of tumor necrosis factor alpha on nitric oxide synthase in nerve growth factor-responding cells
… accompanied by a decrease in nerve growth factor (NGF)-responsive cholinergic neurons. I report a synergistic effect of the cytokine tumor necrosis factor alpha (TNFa) and NGF on expression of nitric oxide synthase (NOS), in rat pheochromocytoma PC12 cells. NGF/TNFa-promoted iNOS can be …
-
Regulatory role of phosphatidylinositol 4-phosphate 5-kinases in brain inflammation
… gene knockdown of PIP5KIα plays a role in the nuclear factor kappa B (NF-κB) signaling pathway. We found that PIP5KIα knockdown could inhibit the phosphorylation of NF-κB p65 in response to Gmix, leading to decrease in Gmix-induced proinflammatory cytokines, tumor necrosis factor α and …
-
Epidermal growth factor-mediated activation of the unliganded glucocorticoid receptor in A549 cells
… the regulatory effects of epidermal growth factor (EGF) on cytokine gene expression in order to determine whether previously published examples of EGF repressing the expression of interleukin 6 (IL-6) mRNA occur in other cell types and whether the effects of EGF are mediated via the GR. This …
-
Systematic Interrogation of the Stiffness-sensitive Transcriptome in Mesenchymal Stromal Cells Reveals an Immunomodulatory LncRNA CYTOR
… investigated. An understanding of the pertinent factors involved would not only aid in the rational design of substrates but also uncover targetable mechanisms that can facilitate the engineering of MSCs for cell therapies. Here, a bone marrow-mimetic hydrogel is employed to systematically …
-
OTULIN's Novel Regulatory Mechanisms in Genotoxic and Inflammatory NF-kB Signaling
… are gradually revealed, including the nuclear factor-kappa B (NF-kB) pathway. Transcription factor NF-kB is widely involved in cancer development and progression, and its overactivation renders chemoresistance to TNBC and induces aberrant inflammation. Therefore, targeting NF-kB becomes …
-
Unraveling the molecular mechanism underlying ALS-linked astrocyte toxicity for motor neurons
… techniques, leading to the discovery that nuclear factor kappa B (NF-κB) is instrumental in the demise of motor neurons exposed to mutant astrocytes in vitro. These findings demonstrate the usefulness of this novel genomic approach to study neurodegeneration and to point to NF-κB as a …
-
Investigating the Role of Pellin03 in TNF Signalling
Tumor necrosis factor (TNF) is an important modulator of the innate immune system, responsible for the activation of immune cells as well as the removal of damaged cells. Aberrant TNF signalling can cause a number of pathologic conditions. TNF binding to TNF receptor 1 triggers the activation of …
-
A transcriptomic approach for studying the activation of dendritic cells in response to mycobacterial infections
… M. tuberculois infection. Interferon Regulatory Factors (IRFs) and NFkB (Nuclear Factor kappa B) appear to be the principal transcription factors involved in regulating the cellular responses in M. tuberculosis infected BMDCs. It has been found that IRFs can function independent of the adaptor …
Page 1 of 4