Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Nuclear Factor I"”.
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Regulation of IGFBP-5 and Osteoblast Functions by Nuclear Factor I
The Insulin-like Growth Factor (IGF) system is a major target of GC inhibition in bone. We found that GCs inhibit expression of IGF binding protein-5 (IGFBP5) which binds IGFs and stimulates osteoblast activity by IGF dependent and independent mechanisms. GC-induced inhibition of IGFPB5 promoter …
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Characterization of Genome-Wide Binding of NUCLEAR-FACTOR I-X in Hematopoietic Progenitor Cells
… other well-known hematopoietic transcription factors, including pSTAT1, RUNX1, RAD21, STAT3, ETO2, FLI1, GATA2, LYL1, LDB1 and PU.1. We showed NFIX and PU.1 together target genes regulating hematopoietic cell adhesion, cell death and differentiation in hematopoietic cells. Our data support a …
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Characterizing The Recognition Motif and Novel Substrates of Carm1
… (Rme2a) antibodies and identified that Nuclear Factor I-B (NFIB) is a major CARM1 substrate. <em>Nfib</em> and <em>Carm1</em> knockout mice die perinatally due to almost identical hyper-proliferation defects during lung development, suggesting a genetic link between NFIB and CARM1. NFIB …
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Coordinating Stem Cell Behavior in the Hair Follicle
… To identify candidate transcription factors that specify HFSCs in mouse, the gene expression profiles of the HFSCs residing in the bulge of hair follicles versus the epithelial basal cells outside the bulge were compared. One of the "molecular signature" genes being upregulated in the …
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Investigating the initiation and progression of small cell lung cancer
… of a novel, protooncogenic transcription factor Nuclear Factor I/B (Nfib in mouse, NFIB in human), which frequently occurred coincident with amplification of a previously characterized oncogene, L-myc (Mycl). Functional studies revealed cooperation between Nfib and Lmyc in cellular …
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Molecular factors influencing epithelial-mesenchymal transition in breast cancer
… E-cadherin. The expression of the transcription factor nuclear factor I-C2 (NFI-C2) is lost during mammary tumor progression and NFI-C2 has been shown to counteract EMT by repressing the transcription factor Forkhead box F1 (FoxF1). FoxF1 induces EMT and invasiveness in breast cancer cells. In …
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Novel mechanism in astrocyte gene regulation and function
… and function by the NFI-X transcription factor which can be further extrapolated to astrocyte differentiation and glial tumor invasion. First, we cloned and analyzed human NFI-X3, a novel splice variant of the nfix gene, which contains a unique transcriptional activation (TA) domain …