Global ETD Search
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Showing 1 to 9 of 9 for “"Nuclear Export Signals"”.
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Nuclear Export Receptor CRM1 Recognizes Nuclear Export Signals with Diverse Conformations
… of Maintenance 1 or CRM1 protein facilitates export of hundreds of proteins and RNA molecules from eukaryotic cell nuclei. CRM1 recognizes its protein cargoes by their 8-15 residues-long nuclear export signals or NESs, which bind to a hydrophobic groove in CRM1. NESs are highly variable in …
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Nuclear export signals (NESs) in Arabidopsis thaliana : development and experimental validation of a prediction tool
… between nucleus and cytoplasm lies in its nuclear export activity. The widely used mechanism for export of proteins from the nucleus involves the receptor Exportin 1 and the presence of a nuclear export signal (NES) in the cargo protein. Given the big amount of sequence data available …
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Molecular Mechanism of Insulin Resistance: Role of mTOR Signaling Pathways
… In this study I initially set out to identify nuclear export signals in mTOR. A systematic scan of the mTOR sequence revealed 16 peptides conforming to the canonical leucine-rich nuclear export signal, of which 3 were found by reporter assays to contain LMB-sensitive and leucine-dependent …
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Subzelluläre Lokalisation des Y-box-Proteins-1 (YB-1) in Mesangialzellen und Charakterisierung der dafür verantwortlichen Proteindomänen
… Within one day YB-1 localizes to the perinuclear region of cells within all glomeruli . In the course of the disease the strongest cytoplasmic YB-1 signal coincided with the peak mesangial cell activation/proliferation between days 4 and 6 and was detected in a mesangial distribution …
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Structural and Biochmical Studies of Nuclear Import Factor Karyopherin Beta-2
Karyopherinbeta (Kapbeta ) proteins recognize nuclear localization and export signals (NLS/NES) and mediate the transport of macromolecules across the nuclear envelope, a process regulated by Ran GTPase through its nucleotide cycle. Diversity and few number of available signal sequences recognized …
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Structural and functional analysis of exportin-cargo recognition
… welche Import-Rezeptoren ( Importine ) und Exportine umfasst. Importin 13 und Msn5p sind Ausnahmen, da sie sowohl Import als auch Export vermitteln. In dieser Arbeit haben wir gezeigt, dass Exportin 4, zusätzlich zu seiner etablierten Rolle als Export-Rezeptor, Transkriptionsfaktoren der …
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Nuclear Export Signal Recognition by CRM1 Carrying the Oncogenic E571K Mutation and Structure-Based NES Prediction
Nuclear-cytoplasmic trafficking is an essential cellular process in eukaryotes that maintains and regulates the spatial distribution of key cellular processes in the nucleus and the cytoplasm. CRM1 is the major nuclear export mediator, which facilitates nuclear export of hundreds of protein and RNA …
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Localisation and function of phosphoinositide-specific phospholipase C in Sacchromyces cerevisiae
… Plc1p is too large to diffuse through the nuclear pore complex, and thus relies on nuclear export signals (NES) and nuclear localisation signals (NLS) to facilitate its passage through the nuclear envelope. By creating mutants of Plc1p that are restricted to one of these compartments: …
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Subcellular Localization of Human T-cell Leukemia Virus Type 1 Tax Oncoprotein
… to perturbation of their functions. Tax has both nuclear and cytoplasmic activities and shuttles between the two compartments via defined nuclear localization and nuclear export signals (NLS and NES, respectively), but the mechanisms regulating nucleocytoplasmic shuttling and targeting of Tax to …