Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Nuclear Egress"”.
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Characterizing the Role of the Herpes Simplex Virus Type 2 UL21 Protein in Viral Nuclear Egress
… in the primary envelopment of capsids during nuclear egress, however the precise mechanism by which it does this is unclear. To investigate the role of UL21 in HSV-2 nuclear egress, we focused on events upstream of primary envelopment. First, we examined the role of UL21 in disrupting the …
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Structural and functional characterisation of pUL21, an α-herpesvirus phosphatase adaptor protein
… correct subcellular localisation of the HSV-1 nuclear egress complex and for virus replication and dissemination. Using in vitro biochemical experiments, stable expression of pUL21 in cultured cells, and infection with wild-type HSV-1 or viruses expressing pUL21 with a mutated TROPPO motif, we …
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Multi-modal imaging of herpesvirus infection
… cell. Capsids assemble in the nucleus, cross the nuclear envelope into the cytoplasm by budding and fusion through the nuclear membranes, and acquire a proteinaceous ‘tegument’ layer in the cytoplasm before becoming enveloped at trans-Golgi network vesicles and/or recycling endosomes. Although the …
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The role of heterochromatin markers in lytic human herpesvirus egress and maturation
… in the host nucleus, assemble capsids then egress out of the nucleus, mature through acquisition of tegument proteins and secondary envelopment, and finally bud out of the host cell. The virus must contend with components of the host nucleus to replicate, including the host chromatin. …
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Relating the structure of the HSV-1 UL25 DNA packaging protein to its function
… entry and recently has been implicated in the egress of the virus from the cell (Coller et al., 2007, Preston et al., 2008). The crystallographic structure of an N-terminally truncated form of pUL25 (residues 134-580) has been determined to 2.1 Å, revealing a protein with a novel fold that …