Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"NuRD complex"”.
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Colocalization between Akirin, the NuRD Complex, and Histone Modifications
… Of the 4 major animal chromatin remodeling complexes, SWI/SNF, INO80, ISWI, and CHD, we know Akirin interacts with subunits of the SWI/SNF family Brahma (BRM) chromatin remodeling complex during myogenesis and cardiogenesis. Interaction between Akirin and CHD family chromatin remodeling …
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The NuRD complex regulates chromatin dynamics driving exit from naïve pluripotency
The Nucleosome Remodelling and Deacetylase (NuRD) complex is essential for exit from naive pluripotency both in mammalian embryonic stem cell (ESC) culture and in vivo. However, the specific mechanisms of chromatin modulation by NuRD in this process have not been fully characterised. This study …
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The Role of the Nucleosome Remodeling and Histone Deacetylase (NuRD) Complex in Fetal γ-Globin Expression
… of the fetal γ-globin gene. Chromatin modifying complexes, including MBD2-NuRD and GATA-1/FOG-1/NuRD play a role in γ-globin gene silencing, and Mi2β (CHD4) is a critical component of NuRD complexes. In the studies presented in Chapter 2, we observed that the absence of MBD2 in a sickle cell …
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Investigation into the Akirin Subcellular Localization and Developmental Interactions
… and the Nucleosome Remodeling Deacetylase (NuRD) complex. Through transfection of <em>Drosophila</em> S2 cells with Akirin mutant constructs we were able to visualize the localization patterns of Akirin and how the patterns relate to the Nuclear Localization Signal (NLS). Data shows that …
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Dissecting the role of CHD4 in the NuRD and ChAHP complexes
… in gene regulation as a core component of the NuRD complex, CHD4 is also found within the ChAHP complex, which contributes to silencing of transposable elements (TEs). CHD4 generally functions to increase nucleosome density, however the specific chromatin remodelling mechanisms employed by NuRD …
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Uncovering The Zeb1 Interactome to Identify Novel Regulators of Metastatic Non-Small Cell Lung Cancer
… nucleosome and deacetylase remodeling complex (NuRD). Through treatment with class I HDAC inhibitors Trichostatin A, we identified that ZEB1 homodimerizes and determine that acetylation at lysine residue 811 regulates this association. Furthermore, we identify the NuRD complex as a …
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CHD Chromatin Remodelers Promote Epigenetic Control of Development in Arabidopsis thaliana
… not function as a member of a multi-subunit Mi-2 NuRD complex. Instead, PKL acts as a monomer in vivo and promotes the epigenetic modification H3K27me3, which is associated with transcriptional repression of tissue-specific genes by the PRC2. Thus, PKL plays an important role in promoting tissue …
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Discovery of Novel Ubiquitin- and Methylation-Dependent Interactions Using Protein Domain Microarrays
… in their unmethylated form, interact with NuRD complex components. These findings provide in vitro evidence that methylation of H3TMs can promote novel interactions with PHD finger- and Tudor domain-containing proteins and block interactions with the NuRD complex. We propose that these …
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The TAZ Protein Interactome in Striated Muscle
… Epigenetic regulators were also represented: NuRD complex, FACT complex, and SWI/SNF complex. We focused on characterizing the TAZ interaction with the Wnt co-repressor TLE3 in myogenic cells. In myogenic cells, TAZ and TLE3 interact and co-localize within the nucleus. Functionally, TAZ and …
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The synthetic multivulva genes and their suppressors regulate opposing cell fates through chromatin remodeling
… of a Nucleosome Remodeling and Deacetylase (NuRD)-like complex and heterochromatin protein 1 (HP1). In addition to a NuRD-like complex, which deacetylates lysine nine of histone H3 (H3K9), and HP1, we found two histone methyltransferase (HMT) genes (met-1 and met-2) that act as class B synMuv …
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Regulation and Function of Zeb1 Acetylation In Lung Adenocarcinoma Progression and Metastasis
… the nucleosome remodeling and deacetylase (NuRD) complex to bind the promoter of <em>mir200c-141</em> and <em>SEMA3F </em>genes. RNA-sequencing revealed that WT ZEB1 and K811Q ZEB1 downregulate the expression of epithelial genes to enhance NSCLC motility, invasion, and metastasis, while the …
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Characterising the interaction between TRIM28 and members of the Krab-ZFP family in transcription silencing
… and the nucleosome remodelling and deacetylase (NuRD) complex. Although many protein partners involved in silencing have been identified, the molecular basis of the protein interactions that mediate silencing remains largely unclear. TRIM28 belongs to the tripartite motif (TRIM) protein family …
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The Nucleosome Remodelling & Deacetylase complex: Genome folding & transcriptional regulation
… as loop extrusion. Chromatin remodeling protein complexes - complexes that can dynamically modify chromatin architecture to control access of key transcriptional machinery to genomic sites - play essential roles in development and control of gene expression. The Nucleosome Remodeling and …
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THE PHD FINGER OF SP140: A STRUCTURAL AND FUNCTIONAL STUDY
… BHC80 PHD finger (Lan et al, 2007) structures in complex with an unmodified H3 peptide. Unexpectedly tryptophan fluorescence and NMR titrations of Sp140 PHD finger with a 15mer H3K4me0 peptide showed no binding, indicating that the presence of the N-terminal acidic hallmark is not sufficient to …