Global ETD Search
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Showing 1 to 3 of 3 for “"Nsp2TF"”.
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The roles of papain-like protease-related proteins in viral replication and host immunity
… nsp2 and two ribosomal frameshifting products-nsp2TF and nsp2N share the same N-terminal PLP2 domain. In chapter 2, nsp2TF and nsp2N were demonstrated to be critical for host innate immunity suppression at least through the PLP2 domain-mediated deubiquitination and deISGylation effects. The …
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Novel approaches to enhance the protective immune responses of vaccines against Porcine Reproductive and Respiratory Syndrome Virus
… the newly-discovered nonstructural protein Nsp2TF of PRRSV as the main mediator in down-regulating SLA-I expression. We also demonstrated that the Nsp2TF-knockout mutant virus lost its function of negatively modulating SLA-I presentation compared to the wild-type virus. The results suggest …
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Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression
… generating alternative forms (nsp2N and nsp2TF) of a viral non-structural protein, nsp2. Frameshift efficiency at both sites was quantified and, at the non-canonical site, was found to increase with time, rendering this the second known example of temporally regulated PRF during …