Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Nrf2-signalling"”.
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Characterisation of Nrf2-signalling and the effects of boosting astrocytic Nrf2 in a mouse model of ischaemic stroke
… Factor Erythroid 2 (NFE2)- Related Factor 2 (Nrf2) is a transcription factor and master regulator of a battery of antioxidant and anti-inflammatory genes such as Heme oxygenase-1 (hmox1), NAD(P)H dehydrogenase quinone 1 (nqo1), glutamate-cystine antiporter (xCT; gene slc7a11), sulfiredoxin 1 …
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Mechanisms of repression of the transcription factor NRF2 by KEAP1- and B-TrCP-dependent ubiquitin ligases and how the dysregulation of NRF2 contributes to lung cancer progression
… since the discovery of the important role that NRF2 plays in regulating the expression of phase II drug metabolism genes, NRF2 has been a highly studied therapeutic target. NRF2 signalling is often elevated in lung cancer due to mutations in NFE2L2, the gene that encodes NRF2; and KEAP1, the …
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Investigation of inflammatory and oxidative stress mechanisms in the disruption of white matter structure and function following chronic cerebral hypoperfusion
… impairment in VCI. One such mechanism is the Nrf2 (Nuclear factor erythroid 2-related factor 2) signalling pathway. Nrf2 is a transcription factor that acts to detect and resolve inflammation and oxidative stress via induction of over 200 antioxidant and anti-inflammatory genes. Studies have …
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Nrf2 in metabolic related inflammation in the brain
… (OS). Disruption of NF-E2-related factor 2 (Nrf2) signalling increases OS and promotes AD. Amyloid precursor protein (APP) is intimately linked with AD, with the Swedish mutation (<i>hAPP<sub>swe</sub></i>) used in numerous transgenic models. Furthermore, increasing importance has been placed …
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Investigating the putative therapeutic effects of sulfophane in the human lens
… demonstrated upregulation at the protein level. Nrf2 was found to actively translocate to the cell nucleus in response to a four hour exposure to 0.5, 1 and 2 M SFN. SFN was found to induce apoptosis and ER stress in FHL 124 cells at SFN concentrations 10 M and higher. Application of these …