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Showing 1 to 16 of 16 for “"Nrf2 activation"”.
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The Temporal and Contextual Relationship of NRF2 Activation and Cancer
The complex role of NRF2 in the context of cancer continues to evolve. As a transcription factor, NRF2 regulates various genes involved in redox homeostasis, protein degradation, DNA repair, and xenobiotic metabolism. As such, NRF2 is critical in preserving cell function and viability, particularly …
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Characterization of the Molecular Mechanisms of Xenobiotic-Induced NRF2 Activation for Disease Prevention and Intervention
… nuclear factor erythroid 2-related factor 2 (NRF2) is the master regulator of the cellular antioxidant response upon exposure to xenobiotics. In addition, NRF2 induces the expression of genes involved in drug metabolism, protein homeostasis, anabolic metabolism, inflammation, proliferation, …
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Discovery and Design of NRF2 Modulators
Nuclear factor erythroid 2–related factor 2, or NRF2, is a key protein responsible for the regulation of numerous signaling pathways in the body, particularly those related to oxidative stress and cytokine release. As such, reduced NRF2 activity has been identified as a contributing factor of …
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Exosome-Mediated Protection Against Oxidative Stress: A Connection Between NRF2 And Exosomes
… factor erythroid 2 (NF-E2)-related factor 2 (NRF2) transcription factor has been widely studied for its role as the master regulator of the response to oxidative stress. NRF2 has many mechanisms for protection including upregulation of antioxidant genes, metabolism genes, and proteolysis …
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Targeting Nrf2 in Inflammation and Cancer
The transcription factor Nrf2 protects against cellular stress by inducing cytoprotective proteins. Activation of Nrf2 protects against inflammation and oxidative damage in disease models in vitro and in vivo. Nrf2 activation may be a good therapeutic strategy in these diseases. Some dietary …
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ANALYSIS OF ELECTROPHILE-INDUCED NRF2 GENE ACTIVATION
Activation of the transcription factor Nrf2 regulates expression of phase II enzymes and other adaptive responses to electrophile and oxidant stress. Nrf2 concentrations are regulated by the thiol-rich sensor protein Keap1, which is an adaptor protein for Cul3-dependent ubiquitination and …
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THE ROLE OF NRF2 IN PREVENTING OXIDATIVE/ELECTROPHILIC STRESS-INDUCED LIVER INJURY
… Nuclear factor, erythroid derived 2, like 2 (Nrf2) is a master regulator of biochemical mechanisms that respond to oxidative/electrophilic stress. Under basal conditions, Nrf2 is held in an inactive state in the cytoplasm by binding to the cytoskeletal anchoring protein Kelch-like …
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The Phytochemistry of Selected Ancistrocladus and Monsonia Species and their Anti-Pancreatic Cancer and Nrf2 Activator Properties
… were screened for the first time for their Nrf2 activity. M. angustifolia sequential extracts exhibited superior Nrf2 activation with three active extracts, n-hexane, methanol, and aqueous extracts showing 169.0, 236.1, and 130.0% increase relative to the control. The methanol extract of M. …
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Investigating the impact of flavonoid metabolites on endothelial function and vascular inflammation
… mRNA response, and mechanisms of action (e.g. Nrf2 and NFB). Additionally, up to 25 combinations of flavonoids and metabolites were explored, reflecting 3 unique serum profiles of cyanidin-3-glucoside (C3G) metabolites observed in vivo post-consumption. HO-1 was increased >20 % in response to …
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Disruption of mitochondrial redox homeostasis as a cellular signal.
… factor erythroid-derived 2-related factor 2 (Nrf2). Until now it has not been possible to disentangle the overlapping effects of mitochondrial ROS signalling compared to a redox signal stemming from disruption of mitochondrial thiol homeostasis. Furthermore, it is important to distinguish …
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Hormetic dietary phytochemicals from Western Canadian plants: Identification, characterization and mechanistic insights
Activation of mammalian stress responsive pathways by plant secondary metabolites may contribute to the protection against certain chronic diseases afforded by fruit and vegetable consumption. This work focuses on the identification of plant compounds that activate the stress-responsive enzyme …
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Testing the Anti-Inflammatory Effects of Dietary Phytochemicals in Intestinal Inflammation Models
… nuclear factor erythroid 2-related factor 2 (NRF2) in a luciferase reporter assay. Yet pure CA was the most potent NRF2 activator. NRF2 negatively represses the pro-inflammatory transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-ƙB) which promotes …
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Reactive oxygen and nitrogen species production in cardiomyoblasts during hypoxia and reoxygenation
… did not effect this during sustained hypoxia. Nrf2 activation during 2% O2, a sustained hypoxia and reperfusion was O2-•/•NO dependent. Inhibition of NF-?B activation aggravated metabolic activity during 2% O2, 4h hypoxia. In conclusion, mitochondrial O2-•, but, not ATP depletion is the major …
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Dual regulation of transcription factor Nrf2 by Keap1 and the beta-TrCP/GSK-3 in cancer
… occurring globally. NF-E2 p45-related factor 2 (Nrf2), a cap-‘n’-collar basic leucine zipper (CNC-bZIP) transcription factor, prevents carcinogenesis through expression of genes that ensure the excretion, enzymatic modification, and repair of oxidative damage in cells containing the antioxidant …
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Investigating the role of transcription factors Nrf2 and Pparα in hepatic lipid metabolism during fasting
… nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) controls the basal and inducible expression of a plethora of genes, predominantly those associated with oxidative stress response through its regulation of the glutathione and thioredoxin based antioxidant systems, and the maintenance of …
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Curbing environmental pollution of water hyacinth by using it in drug discovery
… water hyacinth extracts are potent inducers of Nrf2 (Nuclear factor erythroid 2-related factor 2) dependent ARE-promoter activity. Furthermore, we assessed the impact of extracts on donor human sperm function parameters using CASA and we found that E2 especially, induced ROS and diminished total …