Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Nr3c1"”.
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Epigenetic & transcriptomic alterations associated with childhood maltreatment, major depressive disorder, and post-traumatic stress disorder
… a joint or potentially interacting effect on NR3C1, the glucocorticoid receptor, promoter region DNA methylation using whole blood. A secondary analysis examines the potential functional effect on downstream gene expression levels. Chapter 3 examines whether blood-derived DNA methylation of …
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Molecular Genetic Characterization of Acute Lymphoblastic Leukemia with a Poor Prognosis
… with adult ALL, including the BCAT1, BTLA, NR3C1, PIK3AP1 and SERP2 genes. In articles II-IV the genetic and epigenetic background of hypodiploid ALL was further investigated using SNP array analysis, exome and RNA sequencing, methylation array analysis and FISH analysis. Characteristic …
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From youth to old age: therapeutic potential of microbiota interventions in the gut-brain-axis
… the level of the glucocorticoids receptors (Nr3c1) and corticotropin-releasing hormone (Crhr1) receptors in the amygdala of young mice. In an attempt to understand the mechanisms through which microbiota-targeted interventions exert the anti-aging effects, we used a model of premature ageing …
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EARLY LIFE STRESS EXPOSURE AND HYPOTHALAMIC PITUITARY ADRENAL AXIS: FROM MECHANISMS TO PERIPHERAL BIOMARKERS OF VULNERABILITY
… pronunciato effetto sull’espressione di Sgk1 and Nr3c1 in animali già esposti a PNS suggerendo come l’esposizione a stress nelle prime fasi della vita possa rendere il sistema più “sensibile”, influenzandone la capacità di affrontare situazioni avverse, e possa, inoltre, contribuire …
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Identification of novel biomarkers and therapeutic strategies in triple negative breast cancer
… approach will characterise the role of NR3C1, which encodes the glucocorticoid receptor (GR) in TNBC as a biomarker and a therapeutic target. Secondly, a discovery-led approach will be taken by conducting a high throughput loss-of-function screen in a panel of TNBC cell lines to identify …
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Investigation of miRNAs Expression in a Citron-Kinase Mutant Model of Microcephaly
<p> <p>Mutation of Citron-Kinase (Cit-K) in rodents causes substantial reductions in the number of neurons generated in the CNS and results in a primary microcephaly-like phenotype. Evidence from drosophila genetics has further established a genetic link between Cit-K and a protein Argonaut 1 …
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Regulation of the Glucocorticoid Receptor Promoter and Its Prognostic Value in Tamoxifen-Treated ER+ Breast Cancer
Most breast cancers are estrogen receptor positive (ER+) and therefore benefit from endocrine-based therapies such as tamoxifen which impair estrogen signaling. However, resistance is a major clinical concern and ER status alone is insufficient to predict treatment response. As a result, additional …
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Prenatal stress, the placenta and maternal microbial transmission; implications for health and disease
… with an increase in the glucocorticoid receptor (NR3C1) in placentae from high distressed pregnancies. Additionally prenatal distress was associated with a number of adverse outcomes including delivering via Caesarean section, reduced Apgar scores and reduced birth temperature, supporting a role …