Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 155 for “"Novel treatment"”.
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Novel treatment technologies for arsenic removal from water
… can be used as an effective and economical treatment system in removing arsenic from contaminated groundwater. The merits of the IOCSp filter process are the consistent removal efficiency, long life cycle, and simplicity in operation, regeneration and disposal.
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Investigating novel treatment approaches to combat Clostridioides difficile
Investigating novel treatment approaches to combat Clostridioides difficile Rusha Pal ABSTRACT Clostridioides difficile is the leading cause of antibiotic-induced diarrhea and colitis in hospitals and communities worldwide. The enteric pathogen, classified to be an "urgent threat" by the United …
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Cannabinoids: A Novel Treatment Strategy for Retinal Neurodegenerative Disorders
<p>Synthetic and naturally occurring cannabinoids are known to decrease intraocular pressure (IOP). Glaucomatous damage to the retina and optic nerve progresses even after therapy to maintain normal intraocular pressure (IOP). Topical application of cannabinoids decreases IOP while not affecting …
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Novel treatment strategy for ALK-positive Anaplastic Large Cell Lymphoma
… to inhibit ALK is a conventional second-line treatment and has been trialled for upfront use in combination with the ALCL99 therapeutic backbone. However, an extended duration of treatment is required as cessation of therapy can lead to rapid relapse although this is often salvageable with …
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Synthesis, Characterization and Evaluation of Novel Treatment against Resistant Pathogenic Bacteria
BACKGROUND: Antibiotic resistance amongst microbial pathogens has become a challenge over past decades, bringing about genuine and frequently deadly contaminations that can't be dealt with by ordinary means. This has led to a search on developing solutions to this problem by searching for new …
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FLUOXETINE AS A NOVEL TREATMENT TO ATTENUATE CISPLATIN-INDUCED COGNITIVE IMPAIRMENT
… FLX could sensitize cancer cells to chemotherapy treatment and assist in attenuating CRCI. The aim of this study was to assess the ability of FLX to sensitize cancer cells to cisplatin treatment as well as the ability to attenuate cisplatin-induced cognitive impairment. Combined treatment of …
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Desktop study on Novel Treatment techniques to treat industrial fertilizer effluent
… study addresses this problem by presenting three novel treatment techniques to treat the liquid waste produced from a fertilizer production plant. A liquid waste sample obtained from a particular fertilizer production plant producing primarily nitrogen-based fertilizer is used as a design basis to …
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DEGRADATION OF XIAP AS A NOVEL TREATMENT STRATEGY IN HIGH-RISK NEUROBLASTOMA
The potential of XIAP antagonism as a treatment strategy for neuroblastoma has not been investigated despite neuroblastoma being an embryonal cancer with a developmental biology requiring XIAP. Here, we showed that the targeting of XIAP, and not other IAP members such as c-IAPs, was necessary to …
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Hypoxia and exercise: novel treatment strategy for muscle growth and weight loss.
La investigación previa en el uso del entrenamiento en hipoxia se ha centrado en las adaptaciones y respuestas fisiológicas derivadas de estos programas en deportes de resistencia y deportes colectivos. Además, en los últimos años ha surgido una aplicación terapéutica del uso de la hipoxia como …
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Allogeneic Double Negative T cell Therapy as a Novel Treatment for AML Patients
… (allo-BMT) is a potentially curative treatment for high-risk leukemia patients. However, a high disease relapse rate caused by residual disease and an associated toxicity such as graft-vs.-host disease (GvHD) remain as major issues that hamper recipients' survival. Many forms of …
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Novel Treatment of Anal Fistulas and Endovascular Drug Delivery for Peripheral Arterial Disease
… chances of limb loss. Unfortunately, although treatments exist to open the blood vessel, 12% of patients still experience recurrence. The cause of this is intimal hyperplasia. The drug Amlexanox has been shown to reduce intimal hyperplasia in dogs. In this study we propose a stretch-release …
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Induced-Pluripotent Stem-Derived Neuronal Progenitor Cells As A Novel Treatment For Neurodegenerative Diseases
… (CJD). At this time there is no effective treatment or cure for CJD. The disease is inevitably fatal and affected people usually die within months of the appearance of the first clinical symptoms. Compelling evidence indicate that the hallmark event in the disease is the conversion of the …
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Molecular Mechanisms in Amyloid Disorders. Novel Treatment Options in Hereditary Cystatin C Amyloid Angiopathy.
… of the disorders and strategies for their treatment. In hereditary cystatin C amyloid angiopathy (HCCAA), a cystatin C variant is deposited in arterial walls and causes brain hemorrhage in young adults. Although carriers of the cystatin C variant may be easily identified by genetic testing, …
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Investigating inhibition of porphyrin (heme) synthesis as a novel treatment option for prostate cancer
… For this stage of the disease, there are limited treatment options and there is a need for new therapies that can target these resistant forms of PC. Metabolism is a process often modified in cancer cells. It has been shown that porphyrin synthesis is increased in multiple cancers and targeting …
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Codeine, heightened pain sensitivity and medication overuse headache: a neuroimmune hypothesis and novel treatment strategy.
… disorder remains unclear and mechanism-based treatments are lacking. Although most acute headache treatments are alleged to cause medication overuse headache, within this thesis we conclude from the literature opioids are the drug class most strongly associated with worsening headache. In …
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Developing peptide-based inhibitors of amylin aggregation as a novel treatment for type 2 diabetes
… provide a potential therapeutic strategy for the treatment of type 2 diabetes. In this study, overlapping peptides were designed to target the binding region (RLANFLVHSS, residues 11-20) of human amylin and their effects on amylin fibril formation were studied. The first generation of peptides, …
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Molecular dissection of macrophage-tumour cell interactions to identify novel treatment strategies for pancreatic cancer
… surgical resection of the tumour, radiation treatment and chemotherapy. PDAC cells are highly motile and invasive resulting in infiltrative PDAC with poorly defined borders. PDAC tumours are heavily infiltrated with fibroblasts and subpopulations of immune suppressive cells, macrophages, …
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Therapeutic Vulnerabilities of Venetoclax Resistant Chronic Lymphocytic Leukemia and Novel Treatment Strategies Targeting BCL2/BCL-XL
… either at baseline or at relapse following VEN treatment, which was administered in combination with a BTKi or sequentially as monotherapy after a BTKi relapse. My data supports that <em>BCL2</em> mutations are acquired only in a small fraction, whereas <em>BTK</em> and <em>PLCG2</em> mutations …
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The role of interleukin-32 in infections caused by New World Leishmania species and identification of novel treatment strategies
Contains fulltext : 200683.pdf (Publisher’s version ) (Open Access)
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