Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 153 for “"Novel therapeutics"”.
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Novel therapeutics in the treatment of drug-resistant tuberculosis: a review
… eradication). Here is a compendium of several novel therapies that are being considered to address this global pandemic.
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New financing and business models to accelerate the development of novel therapeutics
… the translation of biomedical research into novel therapeutics. The three examples highlight the potential for creative mission-driven models to speed up drug development and provide capital in the earliest, and often riskiest, stages of drug development. These models are collaborative and …
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A two-pronged approach towards the development of novel therapeutics for advanced endometrial cancer
… as an improved platform to screen for effective therapeutics. The 3D culture system could be leveraged to evaluate novel therapeutics for the treatment of advanced endometrial cancer which may include MUC1 and EGF-directed therapies.
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Structure-Guided Design of Novel Therapeutics Targeting Translesion DNA Synthesis and Lipid A Biosynthesis
… of translesion synthesis inhibitors as a novel class of cancer adjuvant therapeutics to enhance the outcome of chemotherapy currently available to cancer patients.</p><p>Due to their compromised immune systems, cancer patients are particularly susceptible to opportunistic bacterial …
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A Stem Cell-Based Strategy for Modeling Human Kidney Disease and Discovering Novel Therapeutics
… of people worldwide and there are no targeted therapeutics. Given the global burden and increasing prevalence of CKD, the kidneys represent an attractive target for regenerative medicine. The most severe forms of CKD involve irreversible damage to kidney glomerular podocytes - the specialized …
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Studies of the efficacy of Ribonucleotide Reductase inhibition in preclinical models of Acute Myeloid Leukemia in combination with standard and novel therapeutics
Acute Myeloid Leukemia (AML) is an aggressive disease of the marrow with approximately 18,800 new cases each year. The elderly population represents the bulk of AML patients with a median age of onset of 70. More than 70% of AML patients are over the age of 60, and for this group the 5 year overall …
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Analysis of the Role of Bacillus oleronius Proteins in the Induction of Rosacea and Evaluation of Novel Therapeutics for the Treatment of Dermal and Ocular Rosacea
… as an adhesive decoy against antigen. A novel saline therapeutic was also investigated to treat rosacea patients and alleviate symptoms. The novel salt based formulation demonstrated effective anti-inflammatory properties in two pilot studies. There is no cure for rosacea, however the …
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Investigation of inhibitors of polysialyltransferase as novel therapeutics for neuroblastoma. Development of in vitro assays to assess the functionality and selectivity of novel small-molecule inhibitors of polysialyltransferases for use in neuroblastoma therapy
… at low levels in the brain, thus this could be a novel target for cancer therapy. It is hypothesized that inhibition of polysialyltransferasecould lead to control of tumour dissemination and metastasis.The aims of this thesis were to develop tools and in vitro assays to screen novel …
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Novel endoscopes for microscopic assessment of airway clearance using micro-optical coherence tomography
… and phenotyping, and the development of novel therapeutics. In this thesis, a novel, 1-pm resolution, optical interferometric imaging technique termed Micro-OCT was incorporated into miniaturized common-path endoscopes and mucociliary transport was visualized in vivo for the first time. …
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Elucidation of the Proteases Responsible for and the Form of Soluble, Monomeric EphrinA1 Released From Cancer Cells
… 14.5 months. Therefore, there is great need for novel therapeutics with the ability to target GBM cells and spare normal brain tissue. In a search for novel tumor-specific targets, ephA2 was identified as an up-regulated gene in GBM patients. Further analysis demonstrated the overexpression of …
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HIV-1 protease as a target for antiretroviral therapy
… studying the lifecycle of HIV and elaboration of therapeutics targeting nearly every aspect of the viral life cycle, a cure remains elusive. Breakthroughs in HIV research have occurred alongside foundational advances of molecular biology, biotechnology, and medicinal chemistry, highlighting the …
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An organoid platform to study alveolar stem cells in lung generation and cancer
… using a new class of immune-modulatory therapeutics have improved patient survival in the clinic, the majority still invariably succumb to this disease, highlighting the importance of improving treatment strategies. A wide variety of models have been developed to study LADC. Cell line- …
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Optimizing The Nasal Allergen Challenge Model For The Study Of Allergic Rhinitis
… of AR and provides proof of concept for novel therapeutics. The NAC model needs to ensure optimal participant qualification, allergen challenge, clinical symptoms capture and biological samples collection. Repeatability of the protocol is key to ensuring unbiased efficacy analysis of …
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Investigation into the role of DNA damage and repair during influenza infection and inflammation
… disease pathogenesis can aid the development of novel therapeutics to reduce the damage and ameliorate the disease. Here, we studied DNA damage and repair in two inflammatory contexts. First, we investigated the role of DNA damage and repair during influenza infection, a common viral respiratory …
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Epigenetic and post-transcriptional regulation of gene expression in pluripotent stem cells, differentiation and metastasis
… metastasis, this thesis work has identified novel players and regulatory mechanisms underlying these developmental processes and diseases. Furthermore, an attempt to engineer CRISPRzymes - protein fusions of RNA-guided DNA binding dCas9 - will enable experiments to directly test biological …
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Molecular Mechanisms That Govern Human Cardiac Stem Cell Age Disparity
… regenerative ability with age and investigate novel therapeutic strategies to improve cardiac stem cell function. When comparing neonatal and adult cardiovascular stem cell clones, both cell types were capable of cardiomyogenic differentiation. However, the expression levels of forty-one …
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Investigating the role of phosphate homeostasis in Staphylococcus aureus virulence
… of these systems make them a possible target for novel therapeutics to treat antibiotic-resistant bacteria such as Staphylococcus aureus. Previous studies in S. aureus have shown that disruption of phosphate homeostasis by overexpression of the PstSCAB phosphate transporter or loss of function of …
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Understanding the effects of higher order sequence features on peptide MHC binding
… study of immune responses and the development of novel therapeutics. In this thesis we propose the use of sequence feature representations as a means of capturing and categorizing these factors, and we develop the theoretical framework and justification for their use. We then apply sequence …
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Dual-Criterion Dose Finding Designs for Phase I Clinical Trials
… is to assess the safety and tolerability of novel therapeutics. Conventional dose escalation methods identify the maximum tolerated dose (MTD) based on dose-limiting toxicity (DLT). However, as cancer therapies have evolved from chemotherapy to targeted therapies, these traditional methods …
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