Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 32 for “"Novel therapeutic agents"”.
-
TDiscovery and Development of Novel Therapeutic Agents for Advanced Melanoma
… built up a strong basis for the development of novel chemotherapeutic drugs for advanced melanoma.</p> <p>Furthermore, the chemists in our group also synthesized some new imidazole and imidazoline analogs by focusing on the SAR studies of the central five-member ring. Although the current …
-
Ursolic acid and oleanolic acid as novel therapeutic agents in breast cancer
… understood and the search continues to find novel targets for treatment. The effects of non-toxic triterpenes, oleanolic acid and ursolic acid and the role of autophagy and apoptosis as mechanisms to overcome drug resistance in breast cancer were studied in vitro in MCF-7 breast cancer cells …
-
Developing novel therapeutic agents for Acanthamoeba infection and investigating the process of encystment
… to these drugs. There is an urgent need for new therapeutic agents to eradicate the AK infection. This study focuses on the mechanism by which Acanthamoeba may distinguish between trophozoite, cyst and the newly identified lifecycle known as protocyst. The current study has tested 56 novel and …
-
Development of less toxic analogues of fascaplysin as novel therapeutic agents for the treatment of cancer
… and tumour volume in vivo could be of immense therapeutic value for the treatment of cancer. Fascaplysin is a marine natural product which is a potent Cdk4-specific inhibitor. However, fascaplysin also intercalates DNA resulting in S phase block in the cell division cycle and unusual toxicity …
-
Development of in vivo tumour models for non-invasive proof-of-principle investigation of novel therapeutic agents. Engineering and characterisation of bioluminescent cell reporter systems for in vivo analysis of anti-cancer therapy pharmacodynamics.
… is a continued requirement for improved chemotherapeutics. The attrition rate for new therapies is high, due principally to lack of in vivo efficacy and poor pharmacodynamics. Consequently better systems are required to determine in vivo preclinical efficiency and drug-target interactions. …
-
THE NOVEL GEMCITABINE PHOSPHOLIPID CONJUGATE KPC34 HAS ACTIVITY AGAINST MULTIPLE MODELS OF RESISTANT ACUTE LYMPHOBLASTIC LEUKEMIA
… modalities. There is a pressing need for novel therapeutic agents to treat the acute leukemias, especially in the relapsed setting.
-
Inhibition of Deubiquitinase Activity and Ubiquitination of Jak2 Blocks Cytokine Signaling and Induces Tumor Cell Apoptosis
… Such findings have spurred the development of novel therapeutic agents that specifically inhibit Jak2 kinase, thereby suppressing tumor cell growth. Tyrphostin AG490, the first described Jak2 inhibitor, displays poor pharmacology and requires high concentrations for anti-tumor activities. Our …
-
QUB-1985: a bioactive peptide from the frog skin secretion of Odorrana livida
… scientists have been working on developing novel therapeutic agents to replace conventional antibiotics. Antimicrobial peptides (AMPs), possessing broad-spectrum antimicrobial activity, have raised great interests among medical field for its potential bioactivity against bacteria, fungi, …
-
Antileishmania Compounds From An Unidentified Endophytic Fungus And Biotransformation Of 5,7,2`,4`,5`-Pentahydroxyflavonol
… especially in developing countries. Comchemotherapeutic agents currently used are often inadequate, requiring long courses of parenteral administration, having toxic side effects or becoming less effective due to the emergence of resistant strains. Thus, there is an urgent need for new, …
-
Investigating FDA-Approved Drugs for Treatment of Multidrug-Resistant Neisseria gonorrhoeae
… threat that promptly requires the development of novel therapeutic agents. Traditional drug discovery and development is a time-consuming and costly process associated with high risks. To address the dire need to replenish the dry pipeline of anti-gonorrhea medications, drug repurposing is a …
-
Bayesian Adaptive Clinical Trial Design
… and immunotherapies, which provide innovative therapeutic modalities for treating cancers. These novel therapeutic agents work through mechanisms that fundamentally differ from standard chemotherapeutic agents, making the conventional trial design paradigm inefficient and dysfunctional. …
-
Small Molecules Targeting and Modulating Toxic Tau Oligomeric Strains
… the use of small molecules could be a powerful therapeutic strategy that targets toxicity regardless of other factors involved in the formation of tau oligomeric strains. Herein, I used biochemical and biophysical in vitro techniques to characterize preformed tau oligomers and brain-derived tau …
-
The development of next-generation antibody based therapeutics for the treatment of pancreatic cancer
… in dire need of improved detection methods and therapeutics. Currently, less than 20% of patients are eligible for surgery at the time of diagnosis, the only potentially curative treatment regimen available. Many of the remaining 80%+ of patients lack the physical fitness to tolerate the current …
-
In Vitro Investigation on Therapeutic Potential of Juglone, a Naphthoquinone from Walnuts against Pancreatic Cancer
… de novo chemoresistance that develops with chemotherapeutic treatment creates a critical need for identification of novel therapeutic agents for effectively targeting the disease. The effects of juglone on PC cell proliferation, level of reactive oxygen species (ROS) production, and expression of …
-
Identification and Characterization of TONSL as an Immortalizing Oncogene
… as well as facilitate the development of novel therapeutic agents targeting the TONSL interactome.
-
Study of the Phenotypic Characteristics and Genetic Risk Factors of Primary Sclerosing Cholangitis
… signficant association was identified at two novel loci: 10p15 and 12q24, containing candidate genes Il2RA and SH2B3/ATXN2 respectively. These genes have important roles in adaptive immune pathways, implicating an immue mediated disease process in the pathogenesis of PSC. As part of UK PSC, I …
-
The function of the hepatitis C virus p7 protein
… formation is thus important for developing new therapeutic targets. The HCV p7 protein is critical for virus production and an attractive antiviral target. p7 is an ion channel when reconstituted in artificial lipid bilayers, but channel function has not been demonstrated in vivo and it is …
-
Signaling pathways and novel therapeutic strategies for the treatment of murine chronic graft versus host disease
… of disease pathogenesis and for testing of novel therapeutic agents. Donor T-cells, responsible for the initiation disease, require specific signaling pathways and changes in their metabolic profile to sustain their survival, proliferation and differentiation. In cGVHD, activated donor CD4+ …
-
The Calcium Channel Gamma6 Subunit Analysis of Function and Determination of a Sequence Motif Critical for Its Effect
… subunit, and provides a basic approach to design novel therapeutic agents to target calcium channels.
-
The effect of cannabinoids on IL-1beta induced catabolic pathways in osteoathritic chondrocytes.
… of multiple cannabinoid receptors or via a novel cannabinoid receptor.Pro-inflammatory cytokine IL-1beta is a well-known mediator of cartilage degradation, thus the inhibition of IL-1beta induced expression of MMPs and intracellular signalling pathways shown here by WIN-55 suggests that …
Page 1 of 2