Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 39 for “"Novel object recognition"”.
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Exploring the Behavioural Effects of Compound-21 Using Novel Object Recognition and Object in Place Tests in Long Evans Rats
… (CNO), exhibits off target effects on recognition memory assessed with the Novel Object Recognition (NOR) test. While newer DREADD agonists are available, an understanding of how these novel compounds impact rat behaviour unspecific to DREADD activation is lacking. Therefore, I sought …
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Validation of an animal model of cognitive dysfunction associated with schizophrenia. Development and validation of the novel object recognition task using behavioural manipulations and psychotomimetic dosing regimens to induce cognitive deficits of relevance to schizophrenia in hooded-Lister rats.
… reported in chapter 3 were to establish a set of objects with equal preference in the NOR (novel object recognition) test. Furthermore, the inter-trial-interval (ITI) of the NOR test was investigated in an attempt to elucidate the effects of time and location of the rats during the ITI on the …
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Neonatal Phencyclidine (PCP) induced deficits in rats: A behavioural investigation of relevance to schizophrenia.
… then tested in behavioural paradigms such as novel object recognition, spatial memory and social interaction in their adolescent and adult stages and were also tested with acute treatment of typical and atypical antipsychotic agents. Results: Neonatal PCP treatment (10 & 20 mg/kg in males and …
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Locus-coeruleus norepinephrine system function in a developmental animal model of schizophrenia: the socially isolated rat
… behaviour of isolated rats in response to a novel context. The study included both male and female rats so that sex differences could be studied in the context of social isolation. Methodology: Sprague-Dawley rats were weaned at postnatal day (p) 21 and randomly allocated to one of four …
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Efekt konzumace jednoduchých cukrů na kognitivní funkce potkaních samic
… Cognitive functions were evaluated through the novel object recognition (NOR) and Morris Water Maze (MWM) tests. Results, obtained in our study, showed a...
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Vulnerability to cognitive, neurotoxic and neuroinflammatory effects of toxins that induce Parkinson's disease after administration of amphetamine-related drugs in mice
… of cognitive performance by means of the novel object recognition (NOR) and spontaneous alternation in a Y-maze tests. MPTP administration to MDMA-pretreated mice elicited a stronger increase in CD11b and GFAP levels in motor, limbic and cortical areas, and a stronger decrease of …
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Extracellular adenosine as a novel neuroimmune modulator
… before they could be successfully trained in novel object recognition post-hypoxia. Mice also lost the ability to be fear conditioned if trained post-hypoxia. When mice were administered interleukin-1 receptor antagonist prior to hypoxia, mice could be successfully trained in novel object …
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Evaluation of Seizure Threshold as an Early Behavioral Marker of Disease Progression in the Mouse Model of Mucopolysaccharidosis IIIA
… and memory impairments using the Barnes maze and novel object recognition behavioral assays did not show a neurological defect earlier than 20 weeks. These results suggest an intact cognitive capacity for the diseased animals. To test whether seizure threshold is altered in diseased animals, mice …
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Exploration of cognitive and neurochemical deficits in an animal model of schizophrenia. Investigation into sub-chronic PCP-induced cognitive deficits using behavioural, neurochemical and electrophysiological techniques; and use of receptor-selective agents to study the pharmacology of antipsychotics in female rats.
… set-shifting, operant reversal learning, and novel object recognition tasks. The pharmacology of antipsychotics was studied in the reversal learning task using receptor selective compounds. Following this, experiments were carried out using in vitro electrophysiology and in vivo microdialysis …
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Orbitofrontal Cortex and Social Processing in Rodent Models
… and this coincided with an impairment of social recognition (SR) behavior. Additionally, inactivation of OFC by local intracranial injection of GABAA agonist, muscimol, impaired two different measures of SR in which two conspecifics, or members of the same species, one novel and one familiar, …
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A novel developmental rodent model to investigate the neural basis of episodic memory
… in childhood than other types of memory such as novelty recognition, however this ontogeny in animals is so far unconfirmed due to a lack of suitable behavioral tests. The aim of this thesis was to develop a protocol suitable for testing the development of memory in juvenile rats, and to …
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Accelerated Ovarian Failure Causes Neuronal Detriments in the Menopausal Transition that are not Recovered by High Intensity Interval Training
… hormone depletion that occurs in humans. The novel vinylcyclohexene diepoxide (VCD) model allows for the study of how different stages in the menopausal transition can impact physiology and the brain. Exercise can be introduced during the transitionary perimenopausal phase to limit the …
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A non-human primate model of dorsolateral prefrontal cortex dysfunction in schizophrenia
… In Chapter 6, I demonstrate that marmosets show novel object recognition memory at both 5-minute and 24-hour delays, but PNN degradation in the dlPFC impairs recognition memory. In Chapter 7 we used F-DOPA PET imaging to explore the effect of dlPFC PNN degradation on dopamine synthesis, and find …
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smart-Kage: Autonomous behavioural phenotyping in a rodent home-cage environment
… challenges we have developed the smart-Kage, a novel home-cage system for autonomous phenotyping of rodent cognition and behaviour. Its robust and portable design allows easy adoption across different laboratories, while its fully automated operation limits the involvement of experimenters, both …
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The Effects of noise of Zebrafish (Danio rerio) memory
… a plus maze associative learning paradigm and novel object recognition paradigm. The first experiment results showed a significant drop in the total travelling distance in noise-exposed treatments compared to controls without supplementary noise. Moreover, in the noise treatments, there was a …
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EFFECTS OF AT1R ANTAGONIST L-158,809 ON NORMAL BRAIN TISSUE INJURY FOLLOWING WHOLE-BRAIN IRRADIATION
… L-158,809, ameliorated impairment in the novel object recognition task after fractionated WBI. The work in this dissertation tested the hypothesis that blocking the intrinsic brain RAS with L-158,809 before, during, and after WBI would prevent radiation-induced neurobiological changes. The …
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The Effect of Injury Severity on Behavioral Tasks Used for the Assessment of Cognitive Functioning Following Traumatic Brain Injury
… tasks: Dig scent discrimination (Dig) task, novel object recognition (NOR) task, Morris water maze (MWM), and passive avoidance (PA) task. Four days prior to injury, Dig rats were trained to dig in unscented sand and MWM rats were trained to locate a hidden platform positioned in the …
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Cellular and molecular mechanisms underlying anesthetic-induced cytotoxicity, and their impact on learning and memory
… mitigating strategies accordingly. To achieve my objectives both in vitro and in vivo rodent models were used. For the in vitro studies, frontal cortical and hippocampal neurons were extracted from rat pups at postnatal day zero, and these were then exposed to various clinically relevant …
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Role Of The α1A-Adrenergic Receptor In Synaptic Plasticity, Cognition & Neurogenesis
… in CRZ-treated and WT mice, and tested mice on novel object recognition (NOR), Morris water maze (MWM), and open field (OF). No difference was found in NOR and OF. MWM revealed that CRZ-treated mice were protected from Ara-C-induced learning and memory impairments, and surgery-induced learning …
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Temporally distinct impairments in cognitive function following a sensitizing regimen of methamphetamine
… on social interaction (SI), temporal order recognition (TOR) and novel object recognition (NOR) was assessed at one-day and 30-days post induction. No differences were observed in SI in either group or after a single injection of MA. However, an acute injection of 5.0 mg/kg of MA 30-minutes …
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