Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Novel molecules"”.
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Novel Molecules that Regulate Bone Formation and Bone Resorption
… Related protein (DOR), and Claudin 18 (Cldn-18), novel molecules involved in regulating bone formation and bone resorption. We demonstrated that Grx5 protects osteoblasts from oxidative stress induced apoptosis via a molecular pathway that involves regulation of reactive oxygen species production, …
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Novel Molecules from Environmental DNA-Derived Type II Polyketide Biosynthetic Gene Clusters
… and Cragg 2007). However, the discovery of novel natural products from microbes faces the growing hurdle of rediscovering known metabolites. Streptomyces is a microbe that has been a particularly rich source of natural products; however, it has been predicted that the last easily accessible …
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An investigation into novel molecules involved in the development of the nervous system of Drosophila melanogaster
… genes in axon guidance and reveal novel insights into the signalling pathways in which these and established axon guidance genes participate.
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Part I. Enantioenrichment of α-hydroxy acids through lipase catalyzed esterification; Part II. Synthesis, purification and characterization of novel molecule, sulfonium (3-hydroxy-3-carboxypropyl)-dimethyl chloride; Part III. Synthesis, purification and characterization of potential cancer chemopreventive compound,2-hydroxy-4-(methyl seleno)-butanioc acid
"This dissertation is divided into three sections that cover three separate but related topics. The first section deals with a preparative scale separation of 2-Hydroxy-4-(methyl thio)-butanoic acid (HMTBA), the hydroxy analog of limiting amino acid Methionine (Met.)...The second section of the …
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Perturbation Modeling for Molecular Design of Protein Tyrosine Kinase Inhibitors using Unsupervised Machine Learning
… with the aid of new computational tools for novel molecule discovery. In specific, generative deep learning models have excelled as tools to aid in navigating the large space of known molecules and in the creation of new molecules. These models are fed various representations of molecules as …
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Protein-Ligand Binding Affinity Directed Multi-Objective Drug Design Based on Fragment Representation Methods
… show that the proposed method can generate novel molecules with improved property values and binding affinities.
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Modulating protein-protein interactions : novel inhibitors of PDZ domains and tubulin dynamics
… research project designed and synthesised novel molecules which were capable ofmodulating the dynamics of the tubulin dimers or the interactions at PDZ domains.Forty three molecules were synthesised using indole, chalcone and piperidinepharmacophores. These molecules were evaluated either …
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Using chemical catalysis to select and diversify biological-derived intermediates
… selectivity among multiple reactions to produce novel chemicals. Secondly, comparing overall process efficiency in different routes to determine the most reasonable intermediate. Finally, determined critical issues for reactions between high potential molecules. In the first chapter, strategies …
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Development of synthetic routes towards bis (macrocyclic) compounds for imaging and therapy of cancer
Porphyrin molecules are efficient generators of singlet oxygen and are used as photosensitisers in PDT. They are also known to accumulate in tumour tissue due to the hyperpermeability of tumour vasculature and poor lymphatic drainage, thus exhibiting a passive tumour targeting property. …
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Optical Property Prediction and Molecular Discovery through Multi-Fidelity Deep Learning and Computational Chemistry
Optical properties are crucial for the design of molecules for numerous applications, including for display technologies and biological imaging. The accurate prediction of these properties has been the subject of decades of work in both physics-based approaches and statistical modeling. Recently, …
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Novel genotoxins that target estrogen receptor- and androgen receptor- positive cancers : identification of DNA adducts, pharmacokinetics, and mechanism
We have designed and synthesized novel molecules capable of selectively killing tumor cells that aberrantly express steroid hormone receptors. Many human breast cancers express high levels of the estrogen receptor (ER), and most prostate cancers express the androgen receptor (AR). We reasoned that …
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Pharmacological evaluation of the inhibition of polysialyltransferases as a therapeutic strategy in cancer. Characterisation of models for evaluating polysialic acid as a potential therapeutic target and pharmacological assessment of novel polysialyltransferase inhibitors
… high due to uncontrolled metastatic disease, and novel therapeutic approaches for the treatment of neuroblastoma are therefore desperately needed. A potential novel approach for therapy of neuroblastoma relates to the polysialic acid decoration of the neural cell adhesion molecule (PSANCAM). …
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Combinatorial biochemistry of triterpene saponins in plants
… there is an ever increasing demand for novel compounds, due to, among others, the growing drug tolerance and resistance in microorganisms and newly emerging diseases. In microorganisms, combinatorial biochemistry is a widely used tool to increase structural variation in several classes …
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Towards less hazardous chemicals : identifying chemical bioactivity through fish behavioral profiles.
… and reproduction. This dissertation developed novel approaches to diagnostically examine chemicals for toxicity using larval fish models, and further extended these efforts beyond lab raised models to examine effects of neuroactive substances on wild fish populations. In Chapter two, methods …
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Biochemical Characterization of CXCR4 Interactions With HIV -1, Natural Ligands and De Novo Designed Inhibitors
… ligand binding and signaling mechanisms, these novel molecules were shown to be promising leads for the development of anti-HIV and -HAD therapeutics, as they were more potent in blocking HIV-1 entry and infection and less toxic than natural chemokines. The mutational mapping analysis also …
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Structural insights into the GABAA receptor gating cycle
… This approach allowed the visualization of novel and complex asymmetric gating motions involved in the activation and desensitization of the receptor, ranging from side chain to major secondary structure rearrangements. Remarkably, the asymmetric gating cycle is conserved among homomeric and …
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Investigating novel treatment approaches to combat Clostridioides difficile
Investigating novel treatment approaches to combat Clostridioides difficile Rusha Pal ABSTRACT Clostridioides difficile is the leading cause of antibiotic-induced diarrhea and colitis in hospitals and communities worldwide. The enteric pathogen, classified to be an "urgent threat" by the United …
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The Role of Circadian Clock in the Embryonic and Post-Natal Development and Pathophysiology of Oral Tissues and Implications of Natural Treatments in Dental Caries Progression
… phase was to evaluate the impact of suggested novel molecules on caries prevention. We have examined the efficacy of porphyrin molecules and tea tree oil in preventing caries and found that they significantly inhibited bacterial growth and reduced caries prevalence in a rat caries model. …
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Molecular Basis of Mechanosensitivity
… The objective of my research was to identify molecules involved in mechanosensory transduction by both studying known channels as well as performing screens to identify previously uncharacterized channels. Shortly before my research began, Daniel Schmidt from the MacKinnon Lab showed that …
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Discovery and Optimization of a Family of Naturally Encoded Antibiotic Compounds that Evade Antibiotic
… ongoing global health emergency. To combat this,novel potent antibiotics with unique modes of action are required. The classic arsenal of antibiotics used in clinical settings are largely natural products discovered by bulk fermentation of bacterial species isolates that are then extracted and …
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