Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Novel modalities"”.
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Engineered synthetic translational control for next generation mRNA gene therapies
… circuit design to motivate dynamic control for novel behaviors. When I transition to Apply, I illustrate that these next-generation circuits can be layered into biologically active modalities that are therapeutically relevant. Taken as a whole, the work presented here represents a merging of the …
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The development of functionalised stapled peptides as chemical tools to modulate biological processes in platelets and as novel antimicrobial therapeutics targeting Pseudomonas aeruginosa
… were developed as Bcl-2 PPI inhibitors. These novel chemical tools are anticipated to provide valuable insight into the roles of Bcl-2 PPIs in platelet modulation, which could ultimately lead to new therapeutic targets. 2. The development of cleavable stapled peptide-drug conjugates to target …
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Exosomal Survivin-T34A: A Novel, Potential Cancer Therapeutic
… targeting Survivin in this manner may provide a novel approach for selective cancer gene therapy has yet to be ful-ly evaluated. We have recently described that cells generated to express a stable form of the mutant protein, released this Survivin-T34A to the conditioned medium. When this …
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Interrogation and engineering of RAD51:BRC repeat interactions
… using biophysical methods, I investigated a novel, high-affinity chimeric repeat BRC8-2 composed of FxxA and LFDE modules from different natural repeats. I determined the X-ray crystallographic structure of its complex, which allowed me to uncover the determinants of high affinity binding. I …
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Shells and Stages for Actuated TUIs: Reconfiguring and Orchestrating Dynamic Physical Interaction
… of its interactions. In my thesis, I introduce novel hardware augmentation methods, Shells and Stages, for Actuated TUI hardware to expand and enrich their interactivity and expressibility for dynamic physical interactions. Shells act as passive mechanical attachments for Actuated TUIs that can …