Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 36 for “"Novel compound"”.
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A novel compound heterozygous NEB mutationin Korean patients with intellectual disability, epilepsy,and acongenital myopathy
… model. The two affected siblings had the same compound hetero zygous mutation in the NEB gene encoding nebulin, which was composed of two different novel missense mutations: c.2603T>C (p.L868P)in exon 27 and c.21340C>T (p.R7114W) in exon 143. As NEB gene mutations are known to cause autosomal …
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Identification and characterization novel of cystine-loop ligand- gated chloride channels from Dirofilaria immitis: pharmacological analysis and novel compound screening
… and pharmacological characterization of 5 novel receptor subunits from D. immitis: UNC-49B and UNC-49C, ACC-1, LGC-46 and LGC-47. Additionally, novel derivatives of the antiparasitic drug levamisole were tested on ACC receptors to determine if any modifications enhanced levamisole action. …
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Pharmacokinetic Evaluation of a Novel Compound, Sn79, a Putative Sigma-2 Receptor Antagonist, By Intravenous and Oral Administration in Rats
… and addiction. In this view, SN79, a synthetic compound with selectivity to both sigma-1 and sigma-2 receptors garnered our attraction for its use as an antagonist. This dissertation encompasses detailed investigation of SN79 from drug discovery and development perspective. Development and …
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Secondary Metabolites from Xylaria Endophytes: The isolation and structure elucidation of secondary metabolites from Xylaria endophytes by chemical and spectroscopic methods
… 8(5//)-one, which is a novel compound. The fungi A217R and A517R produced cytochalasin D, (S)-mellein and (3S,4S)-4-hydroxymellein as main secondary metabolites suggesting that the two fungi are the same species. The fungus X04 (Xylaria cf. juruensis) produced …
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The addition of oxygen to coordinated thiophene
… can be reduced with two electrons to give the novel compound Cp*Rh(TMT), which features an $\eta\sp4$-bound tetramethylthiophene ligand with the sulfur atom oriented away from the metal center. The thiophenic sulfur atom in this complex is extremely nucleophilic, as shown by the reaction of …
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Therapeutic Approaches to Insulin Resistance and Type 2 Diabetes
… murine diet-induced model of type 2 diabetes, a novel compound, RTC-1, designed to reduce serum levels of one such adipokine, RBP, improved glucose handling and prevented weight gain. This compound also had a direct positive effect on glucose uptake in vitro, independent of its predicted mode of …
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Isolation, Structure Elucidation, and Synthesis of Natural Products from Marine Cyanobacteria
… that differentiate them. Attempts to purify the compound responsible for this affinity led to the isolation of the known compound caylobolide A. A second extract from a cyanobacterium collected in Panama underwent bioassay-guided fractionation and yielded the novel compound naranjamide, which …
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Characterization of a novel cellulose biosynthesis inhibitor, CBI28, in Gluconacetobacter xylinus
… for microbial cellulose biosythesis, a novel compound, CBI28, was used as an inhibitor along with classical genetics and EMS mutagenesis. An EZ-Link Biotin Hydrazide Kit was used to create a CBI28-Biotin conjugate for further studies. Gluconacetobacter xylinus cells were exposed to 10 uM …
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Discovery and biological evaluation of ferroptocide
… diverse small molecules. The resulting compounds have physicochemical traits different from those in most screening collections, and as such are a rich source for biological discovery. Herein, we subject the complexity-to-diversity library of compounds to an anticancer phenotypic screen. …
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β-Sitosterol Isolated from Theobroma Cocoa Induces the Expression Of Mkp-1 and Il-10 In Trigeminal Neurons
… that cocoa beans contain anti-inflammatory compounds that can repress activation of trigeminal nerves. These results led me to hypothesize that a novel compound could be isolated from cocoa beans to treat inflammatory disorders such as migraine and temporomandibular joint disorder. In my …
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Inhibition of Deubiquitinase Activity and Ubiquitination of Jak2 Blocks Cytokine Signaling and Induces Tumor Cell Apoptosis
… Such findings have spurred the development of novel therapeutic agents that specifically inhibit Jak2 kinase, thereby suppressing tumor cell growth. Tyrphostin AG490, the first described Jak2 inhibitor, displays poor pharmacology and requires high concentrations for anti-tumor activities. Our …
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Engineering Novel Bandpass Tools for Cascading Gene Expression
… efficiency. This thesis aims to construct a novel compound logical operation called the Cascade, designed for system optimization and precise, conditional control. The Cascade implements the architecture of a triple sequential logic operation capable of processing four-signal inputs, …
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Activity-guided fractionation of different wheat grain varieties
… screened for starch digestion inhibitory compounds. Overall, the profiles of the dominant antioxidants in the three wheat varieties were very similar, with the exception of anthocyanins, which are only present in the pigmented blue wheat. One novel compound, …
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Antibacterial Evaluation of Polygonum Multiflorum
… spores. Thus, Chinese Knotweed may serve as a novel compound in the treatment and management of bacterial infections and biofilm formation.</p>
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Part I : Isolation Of Dipentyl 2-(4-(pentan-3-yl) Phenyl) Malonate From Sanguisorba Officinalis Labill Part II: Synthesis Of A Novel Family Of Ethers Of Podocarpic Acid
… I of this thesis was to isolate pure anti cancer compounds from the Russian plant Sanguisorba officinalis. This plant was selected for investigation because it showed 100% activity against leukemia (L1210 mouse leukemia cells) during the preliminary screening of approximately 100 Russian plant …
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Novel Methods For The Analysis Of Organometallic compounds For The Natural Environment
… by man in tonnage quantities. Organometallic compounds have found a multiplicity of uses in both industrial and non industrial applications. Specific applic.,ations of organometallics include, polymer stabilisation, biocidal uses, agricultural uses, catal1tic applications and as additives in …
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Design and Synthesis of Antimycobacterial Agents
… of synthetic and structurally conservative compound libraries failing to produce new therapeutics. This has led to a renewed interest in utilising phenotypic screens, but rather than applying them to natural product libraries and running the risk of rediscovering known antibiotics, applying …
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Birds of a Feather: Cultural and Ecological Relationships between the Unangax̂ and Seabirds in the Aleutian Islands, AK
… after the 2014-16 marine heatwave, my use of a novel compound-specific stable isotope application establishes ecological baselines that underscore their sensitivity to shifts in marine fish productivity. Taken together, this dissertation provides evidence that Subarctic marine ecosystems and …
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The total synthsis off linear anthrasteroids.
… was regiospecifically annulated to give the novel tricyclic enone, (+/-)-1beta-t-butoxy-9abeta-methyl-l,2,3,3aalpha,4,7,8,8abeta,9,9a-decahydro-6-benz[f]indenone via two different routes. Thestereochemistry of the new ring junction was elucidated by using H n.m.r. spectroscopy and the …
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X-ray crystal structures of: [Rh2(N-{2,4,6-CH3}C6H2)COCH3)4]•2NCC6H4 AND Ba1.5[Fe(C10H13N2O7)][Co(CN)6]•9H2O; two crystallographic challenges
<p>The novel compound, [Rh<sub>2</sub>(N-{2,4,6-CH<sub>3</sub>}C<sub>6</sub>H<sub>2</sub>)COCH<sub>3</sub>)<sub>4</sub>] was synthesized. Crystal structures of [Rh<sub>2</sub>(N-{2,4,6-CH<sub>3</sub>}C<sub>6</sub>H<sub>2</sub>)COCH<sub>3</sub>)<sub>4</sub>]·2NCC<sub>6</sub>H<sub>5</sub> and …
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