Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 119 for “"Novel Therapies"”.
-
Developing novel therapies for Mycobacterium abscessus
… wide range of the currently available antibiotic therapies. In particular, it causes problems in patients with Cystic Fibrosis (CF) with evidence of marked inflammation, frequent infective exacerbations and an accelerated decline in lung function. Current treatment outcomes are extremely poor. …
-
Development of novel therapies for gut dysbioses
… findings in this Thesis will lead to new therapies that will result in significant clinical improvements.
-
Identifying Molecular Targets and Validating Novel Therapies For Ovarian Cancer
<p>Re-purposing of targeted therapies for additional tumor types is a promising avenue for expanding treatment options for cancer patients, however accurately predicting what re-purposed targeted therapy will be effective remains challenging. To address this need, we developed a Therapy Predicting …
-
Prevention of stroke: risk stratification and targeted and novel therapies
Stroke is a common disorder with dire consequences for the patient and for society and will increase in prevalence over the coming years. Following stroke, many patients unfortunately suffer a further stroke, and recurrent strokes account for approximately 25% of the total. Considerable scope …
-
Developing Novel Therapies Targeting the Tumor Microenvironment of Aggressive Breast Cancer
… and aggressiveness. Therefore, we explored novel actionable targets and complementary therapies targeting the TME to improve the outcomes of patients with these cancers.</p> <p>In this thesis, we identified AXL as a potential therapeutic target in IBC due to its role in generating an …
-
Studies into novel therapies for the treatment of inflammatory artery disease
… AAA and atherosclerosis in these mice. This novel research provides new insights on the roles of MPO and SSAO in AAA and atherosclerosis and identified clinically-viable inhibitors of MPO and SSAO and a class of biodegradable immunomodulatory nanoparticles as potential new therapeutics for …
-
“Vicarious Exposure”: Experimental Studies Towards Developing Novel Therapies for Obsessive-Compulsive Disorder
… to respond to any kind of treatment. Developing novel therapies for OCD—the aim of this thesis—therefore represents an urgent unmet need. Study 1 examined vicarious contamination sensations and relief in OCD. Study 2 explored the therapeutic utility of the “rubber hand illusion” (RHI) and …
-
Novel therapies for cancer treatment : designing high affinity selective ligands against SIRT1 enzyme
… approach known as SELEX. A total of eight novel SIRT1 aptamers (circular and linear), four circular aptamers from 8 rounds of circularisation-SELEX procedure, and the other four linear aptamers from 12 rounds of a basic-SELEX procedure were generated.The initial screening using the Fluor de …
-
Exploring Cancer Stem Cells (CSCs) pathways to design novel therapies for glioblastoma treatment
… and the consequent development of targeted therapies.
-
Development of Novel Therapies for Marfan Syndrome using a Human iPSC-disease model
… mutations and that there is a need to develop novel strategies to identify new putative disease mediators and signalling pathways that participate in the pathogenicity. Here, I use a patient iPSC-derived in vitro disease model that recapitulates the complexity of the patient abnormalities …
-
Generation of a Medaka Fish Model of Propionic Acidemia for Development of Novel Therapies.
… morbidity remain elevated and investigation of novel and more effective therapies is highly needed. <br></br><br></br> I have generated a PA model in medaka fishes (<i>Oryzias latipes</i>) using TALENs targeting the <i>pccb</i> medaka gene, encoding one of the subunits of PCC. The …
-
Modeling Diamond-Blackfan Anemia in the Mouse: Disease Pathogenesis and Evaluation of Novel Therapies
… to study DBA pathophysiology and to evaluate novel therapies. In article I we generated and characterized novel mouse models for RPS19-deficient DBA. These models contain a doxycycline-regulatable Rps19-targeting shRNA that allows an inducible and graded downregulation of Rps19. We demonstrate …
-
Novel therapeutics in the treatment of drug-resistant tuberculosis: a review
… eradication). Here is a compendium of several novel therapies that are being considered to address this global pandemic.
-
Protective Immunity in Atherosclerosis
The immune system is a promising target for novel therapies that are aiming at reducing cardiovascular diseases. Autoimmune responses against modified low density lipoprotein (LDL) are believed to promote development of atherosclerosis. Proinflammatory immune responses can be counterbalanced by …
-
Adaptive designs for complex dose finding studies
… This monotonicity assumption can be violated for novel therapies and for more advanced trials studying drug combinations or schedules. It also becomes common to consider a more complex endpoint rather than a binary one as they can carry more information about the drug. Both the violation of the …
-
Association of baseline sex hormone levels and prevalent and incident peripheral arterial disease in the Multi-Ethnic Study of Atherosclerosis
… this disease are continuing to progress, new and novel therapies are being studied regularly. Increasingly, the role of endogenous and exogenous sex hormones (including estrogen and testosterone) in the development and treatment of cardiovascular diseases is being examined. In this thesis we …
-
Severe community-acquired pneumonia
… and outcome. In addition, different aspects of novel therapies and specific aetiological varieties of pneumonia which have been investigated over the past ten years will be presented.
-
Biogenic silver nanoparticles synthesized using eucomis autumnalis bulb aqueous extract, their characterization and in vitro antibacterial activity
… which is further increased by a reduced novel antibiotics discovery rate. AMR bacteria lead to hard-to-treat infections, causing longer hospital stays and higher healthcare costs, and is associated with a substantial risk of morbidity and mortality. Consequently, the development of …
-
ENDOGENOUS CANNABINOID SYSTEM MODULATION OF THE REINFORCING PROPERTIES OF ETHANOL DURING DEPENDENCE: IMPLICATIONS FOR ALCOHOL USE DISORDERS
… and negative aspects of reinforcement. Effective novel therapies for AUDs should thus attenuate the relative reinforcing properties of ethanol through modulating the activity of these underlying neural circuits.
-
Resistance to hepatitis C virus : potential genetic and immunological determinants
… potential targets for vaccine design and inform novel therapies.
Page 1 of 6