Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Novel Ligands"”.
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Iron catalyzed C-H activation and synthesis of novel ligands
… ethers were developed. Also, the synthesis of novel nitrogen containing ligands such as 1,4,7-triazacyclononane (TACN) derivatives and dipyridylamine derivatives was undertaken.Iron-catalyzed benzylic oxidation was successfully performed by using a combination of iron(III) chloride (2 mol%) as …
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Synthesis and evaluation of novel ligands for quantum dot stabilisation and polymerisation studies
… modification of quantum dots. The ability of the ligands to modify the surface chemistry via displacement of the original hexadecylamine capping layer of quantum dots was evaluated. Finally the surface modified quantum dots were investigated for enhancement in their inherent properties and …
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Advances in myotonic dystrophy type 1 drug discovery through design of novel ligands and mechanism establishment
… (Chapter 2) and a small library of dimeric ligands (Chapter 3) leading to an optimized bivalent ligand. These novel ligands target CUGexp RNA and are able to inhibit the CUGexp⋅MBNL1 interaction in cells that model DM1. In a DM1 cell model these ligands were found to disperse CUGexp …
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Automated Ligand Design in Simulated Molecular Docking - Optimising ligand binding affinity through the application of deep Q-learning to docking simulations
… algorithms that can automatically design novel ligands for biological targets. Recent work has demonstrated the viability of deep reinforcement learning, generative adversarial networks and auto-encoders. Here, we extend state-of-the-art deep reinforcement learning molecular modification …
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Evaluation of Peptides and Peptide–Doxorubicin Conjugates Designed and Synthesized for Targeting Triple-Negative Breast Cancer via Cell-Surface Receptors
… of these agents to biomarker-specific ligands. This forms the foundation of ligand-targeted drug delivery. Among different breast cancers, treatment of the triple-negative breast cancer (TNBC) subtype has been particularly challenging, largely due to the absence of a well-defined …
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Metal ion equilibria in biofluids - copper and rheumatoid arthritis
… Based on the results of the simulation, two novel ligands, 3,6,9, 12-tetra-azatetradecanedioic acid (dtda) and 3,6,9,-triazaundecanedioic acid (dtda) have been synthesised using a three step route. Multiple carboxylation was prevented by using the tosylate protecting group. The compounds were …
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Investigations into dianionic scorpionate ligands and their metal complexes
… and selectivity of a catalyst. Scorpionate ligands are an easily tunable and display flexible binding modes in that they can act as bidentate or tridentate donors. In literature scorpionate ligands with charged donors are underrepresented and this is an area with great potential to explore …
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Synthesis and study of ligands for Pd-catalyzed C-O and C-N coupling
… Using Pd catalysts containing these ligands, electron-neutral aryl bromides were coupled with phenols at room temperature for the first time. A variety of electron-deficient aryl halides and phenols were also coupled at moderate temperatures in good yields. In order to probe how the …
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Ligand Design For The Separation Of Rare Earth Elements
… describes work on the development of novel ligands that form water- and oxygen-stable rare earth complexes, to facilitate the separation of rare earth mixtures into purified elements to enable recycling. Derivatization of a tripodal hydroxylamine ligand demonstrated that changing the …
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Underutilized Dineophiles: Asymmetric Diels-Alder Reaction of Ynones and Ynoates with Oxygen-Functionalized Dienes
… cases have used the cycloaddition to develop novel ligands, and create polymers. My research focus is on the use of oxygen-functionalized dienes in an enantioselective Diels-Alder reaction using ynones and ynoates (Figure A1).The proposal is to use electron-rich dienes, similar to …
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Multidentate phosphino-alkene ligands and their late transition metal complexes
… conformationally flexible phosphino-alkene ligands, called dbaPHOS (127) and monodbaPHOS (128), are described is this PhD thesis. The related phosphine sulphide ligands, namely dbaTHIOPHOS (137) and monodbaTHIOPHOS (149), have also been prepared. The coordination chemistry of the novel …
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Encoding and Processing of Accessory Olfactory System Odorants
… of targeted research, there are only a few known ligands for this system limiting our ability to understand how odorants are processed. Part of my thesis has focused on the discovery of novel ligands for this system. I discovered that feces are a novel and potent source of accessory olfactory …
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Computer-Aided Design of Ligands at Multiple Protein Targets for Multifactorial Diseases
… discovery predominately focuses on the design of ligands with high selectivity towards a specific biological target. A significant limitation in the case of multi-factorial diseases (e.g. neurodegenerative disorders) is that effective therapy may require multi-target drugs addressing the …
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Experimental and Computational Advancements in Peptidomimetic Ligand Discovery
… to decode complex mixtures of peptide ligands pulled down from a peptide library through affinity selection. This approach provides unique advantages due to the high levels of chemical customization that can be performed on synthetic peptide libraries, including the incorporation of …
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Amphiphile Phosphane für die Anwendung in neuen polaren Medien
… the synthesis and characterisation of phosphine ligands for the special use in polar media specially ionic liquids. The novel phosphine ligands have been functionalised with ionic or polar groups for catalyst immobilization tasks. A point of main effort were imidazol- and imidazolium-groups who …
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Chemistry of rhenium(I) tricarbonyl complexes of biomedical relevance
… with <span class=SpellE>triamine</span> ligands (L). When L<b style='mso-bidi-font-weight:normal'> </b>had two primary or two tertiary terminal amine groups, the expected <i style='mso-bidi-font-style:normal'>fac</i>-[<span class=GramE>Re(</span>CO)<sub>3</sub>L]<sup>+ </sup>complexes …