Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Novel Genetic Variants"”.
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The role of novel genetic variants and DNA methylation as risk factors for tendon pathology in physically active individuals
… aims of this thesis were to investigate whether novel genetic variants (copy number variation (CNV) and single nucleotide polymorphisms (SNPs)) in candidate genes were associated with Achilles tendon pathology (ATP) and to investigate whether DNA methylation status was altered in patellar …
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Computational methods for inferring regulatory mechanisms from sequence and expression variation
… cost of sequencing technologies, more and more novel genetic variants are being detected. Numerous human genetic and bioinformatic studies associate genotype data to phenotype information and provide increasing number of phenotype-related variants. Despite the large number of associations been …
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The genetic determinants of cardiovascular disease in patients with type 2 diabetes
The aim of this thesis was to identify genetic determinants associated with cardiovascular disease. We developed and verified algorithms to identify Coronary artery disease (CAD) , ischaemic stroke (IS) and lower extremity arterial disease (LEAD) cases and controls from electronic medical record …
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Genetic factors associated with neuropathic pain
… NP is multifactorial, with evidence of both genetic and environmental factors contributing to its development. Although the genetic contribution to NP susceptibility has been recognised in recent decades, the underlying mechanism remains elusive. The aim of this research was to identify …
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Genome-Wide Association Analysis of Major Depressive Disorder and Its Related Phenotypes.
… risk factors for MDD, identify genome-wide genetic variants affecting neuroticism and age at onset as quantitative traits, and detect gender differences influencing neuroticism.</p><p>Bivariate and multiple logistic regression analyses were performed on 1,738 MDD cases and 1,618 non-MDD …