Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Notch3"”.
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Notch deficiency leads to arteriovenous malformations and altered pericyte function
… whereas pericytes express both Notch1 and Notch3. Here we show that Notch signaling is essential for pericyte function. Through genetic manipulation and pharmacological tools we show that Notch regulates pericyte recruitment and pericyte/endothelial cell interactions. Notch1^+/-;Notch3^-/- …
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Unravelling the Genetics of Cerebral Small Vessel Disease
… and leukoencephalopathy (CADASIL) is caused by NOTCH3 variants, and the second most frequent, CADASIL type 2, by autosomal dominant HTRA1 variants. COL4A1/2 variants can cause small vessel stroke and intracerebral haemorrhage. This thesis investigates the genetics of CSVD in the context of …
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Identifying Molecular Targets and Validating Novel Therapies For Ovarian Cancer
… impact relevant oncogenic gene targets, such as Notch3,<strong> </strong>in this disease. In our pre-clinical models, we demonstrated that BETis produce therapeutic effects and prolong survival. Furthermore, we discovered that BRD4 directly regulates Notch3 transcription and its downstream …
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Identification of a vascular smooth muscle cell transition associated with fibrous cap formation and induced by thrombin receptor activation
… (including fibrillar collagens and elastin) and NOTCH3, a factor that has recently been linked to fibrous cap formation through VSMC regulation. Computational trajectory analysis inferred that this fibrous cap-associated VSMC (fcVSMC) state is derived from a plastic intermediate VSMC population …
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Cancer Cell Antiviral Signaling Amplifies Transcription Output Through Chromatin Alterations To Drive Therapy Resistance
… stromal cells activate Notch receptor 3 (NOTCH3) on BrCa cells and STAT1 amplifies NOTCH3 transcriptional responses to expand therapy-resistant tumor-initiating cells. Stroma-mediated resistance is abrogated by combining radiation with gamma secretase inhibitors. Thus, stromal cells …
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Factors Influencing the Somatic Mutational Landscape of Ageing Squamous Epithelium
… FAT1 are more strongly selected, whilst those in NOTCH3 more weakly selected, suggesting changes to levels of competition within the tissue with age. I conclude that the mutational landscapes of normal oesophagus and skin are shaped by age and environmental exposures and that this, in turn, may …
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Notch Signaling Inhibited By Ikaros1 In Human T-Cell Acute Lymphoblastic Leukemia
… regulated. Specifically, constitutive Notch3 activation promotes expression of non-DNA-binding Ikaros isoforms <em>in vivo</em>, leading to loss of Ikaros function. Additionally, Ikaros regulates Notch by competing for binding sites in the promoter regions of Notch target genes, Hes1 …
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miR-322/503 Cluster Drives Cardiac Differentiation by Inhibiting CUG-binding Protein 1
… of early neural markers, including Sox1, Notch3, Nestin and Pax6. In summary, we have identified a miR-322/503-Celf1 pathway that promotes cardiac differentiation by preventing activation of other lineages. This new regulatory mechanism may be used to direct cardiac regeneration after …
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Genetics of Cerebral Small Vessel Disease
… (CADASIL), caused by mutations in the NOTCH3 gene. In recent years, other genes have also been found to cause familial SVD, such as COL4A1/A2, HTRA1, FOXC1 and TREX1. Genome wide association studies (GWAS) have also revealed loci associated with sporadic SVD strokes and its related …
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Untersuchung zur Rolle von Notch1 in T-Zellentwicklung und Lymphomgenese
… Dabei könnte die beobachtete Hochregulation von Notch3 ein möglicher Mechanismus der Tumorgenese in NICA-Ratten darstellen. Um die Ursache der Lymphomgenese besser zu verstehen, wurde eine genomweite Expressionsanalyse der Tumore mittels SAGE und Affymetrix DNA-Chips durchgeführt. Dabei wurden …
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PKB/Akt : a critical regulator of lymphocyte, development and function
… expanded B cells revealed increased Blimp-1 and Notch3 expression in myr PKB tg B cells, which might be primary candidates involved in their enhanced effector function. In summary, this study clearly shows an important cross-talk between PKB and various critical signalling molecules downstream of …
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Elucidating the Multi-omics of Early-Onset Colorectal Cancer
… significant co-occurrences of FBXW7 with NOTCH3, RB1, and PIK3R1. This study highlights the significance of age-specific molecular profiling, offering insights into the unique biology of EOCRC and potential clinical applications.</p>
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3D Human Skeletal Muscle Model for Studying Satellite Cell Quiescence and Pompe disease
… characterized by a higher Pax7, Spry1, and Notch3 expression, as well as increased functional myogenesis demonstrated by formation of myobundles with higher contractile strength. To examine 3D SC activation, we tested several myobundle injury methods and identified treatment with a bee …