Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Notch-1"”.
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Notch-1 Activates Nf-Кb Activity in Cervical Cancer and Estrogen Receptor Negative Breast Cancer
… prognosis.</p><p>Emerging data indicate that Notch-1 is aberrantly regulated in human cervical and ER- breast cancer and inhibiting Notch-1 sensitizes cancer cells to apoptosis. However, the mechanism by which Notch-1 promotes cell survival is not known. NF-КB is also deregulated in these two …
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Targeting the Notch-1/IGF-1R/Akt Axis in at Orthotopic Model of Advanced Non-Small Cell Lung Cancer
… and we have previously found that Notch signaling plays a crucial role in NSCLC. Our preliminary results indicate that Notch-1 provides necessary survival signals to NSCLC cells by positively regulating IGF-1R to activate the Akt-1 pathway. Therefore, the overall hypothesis is that …
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Polyomavirus Enhancer Activator 3 (PEA3), a Member of the Ets Family of Transcription Factors, Is a Transcriptional Activator of Notch-1 and Notch-4 in Breast Cancer: An Opportunity for Novel Combinational Therapy
… proliferation, survival, and invasive phenotype. Notch-1 and Notch-4, both potent breast oncogenes, are overexpressed in triple-negative breast cancers-associated with the poorest overall survival. PEA3 (polyomavirus enhancer activator 3), a member of the Ets family of transcription factors, is …
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Novel Role of ErbB-2 in Inhibition of Jagged-1-Mediated Trans-Activation of Notch in Breast Cancer
… or overexpression of ErbB-2 inhibits Notch-1 transcriptional activity and trastuzumab or lapatinib increased</p><p>Notch-1 transcriptional activity. Furthermore, Notch-1 is a breast oncogene and a novel target for the treatment of trastuzumab resistant ErbB-2 positive breast cancer in …
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Intervention of non-small cell line cancer oncogenic pathways with delta-tocotrienol
… that 30 % of NSCLC patients have increased Notch activity and 10% of NSCLC have gain-of-function mutation on Notch-1 gene. Our data demonstrated that delta-tocotrienol could inhibit NSCLC cells proliferation, invasion and induce apoptosis by down-regulation of the Notch-1 signaling pathway. …
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The Role of IGF-1 and Notch Signaling in Thoracic Malignancies.
… we focused our research on the role of Notch signaling in cancers of the thorax. Notch-1 signaling has been shown to be required for the growth of SV40-transformed HM. We therefore expanded the studies of the role of Notch signaling in MM and NSCLC. We have found that, under hypoxia, the …
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Notch signaling pathway in human vascular smooth muscle cell differentiation
Notch receptor-ligand interactions are a highly conserved mechanism, originally described in developmental studies using Drosophilae, that regulate inter-cell communication and dictate, in part, vascular smooth muscle cell (VSMC) fate in response to mechanical stimuli. VSMC differentiation is a …
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Role of Rap and Rho GTPases in T-acute lymphoblastic leukaemia cell adhesion and migration
… patients. The most common is the mutation of the NOTCH 1 oncogene occurring in more than 50% of patients. Poor prognosis has often been shown to correlate with the migration and accumulation of T-ALL cells in the tissues. Rap and Rho family GTPases play key roles in T cell adhesion and migration …
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Genetische Aberrationen von Enteropathie-Typ T-Zell-Lymphomen
… im Bereich 9q34, dem Genlokus für c-abl und Notch-1, als die häufigste Aberration heraus, welche sich bei 40% der informativen Genotypen nachweisen ließ. Weitere häufige Aberrationen fanden sich in 5q33-34, 7q31, 6p24, 7p21 und 17q23-25. Bei der Analyse des Verteilungsmuster der Aberrationen …
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Notch Signaling in Neuroblastoma and Renal Cell Carcinoma
The Notch signaling pathway governs cell functions essential for normal development and organogenesis. Aberrant Notch signaling has been implicated in tumorigenesis by perturbing control of proliferation, differentiation, apoptosis, migration and angiogenesis. Neuroblastoma is an embryonal tumor …
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Modification of Lipid Microenvironments on Solid Support Structures for Use in Transmembrane Protein Assays
… Alzheimer’s disease. γ-secretase cleaves both Notch-1, a transmembrane signaling protein, and Amyloid precursor protein (APP), a transmembrane protein whose cleavage may result in the formation of β-amyloid plaques in the brain. Notch-1 and APP are widely studied proteins that have substantial …
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Regulatory Proteins in Progenitors and Differentiated Cells of the Human Prostate
… Dlk-1. We also supply evidence that nuclear Notch-1 activity down-regulates the candidate SC marker Dlk-1 in differentiating glandular precursor cells, that Notch-signalling regulates proliferation of precursor cells, and that inactive Notch-1 is a marker of mature glandular cells in the …
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Mechanistic Insights into the Notch signalling pathway through Molecular Condensation
… pathway in interpreting this information is the Notch signalling pathway. It is currently poorly understood how Notch is able to play a titratable role in signal transduction as our current model does not effectively translate how fluctuations in Notch signalling lead to dynamic changes in Notch …
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Investigating the role of the post-transcriptional regulator protein ZFP36L1 in B-cell functions
… include TNF-a, GM-CSF, VEGF, IL-3, C-IAP2, NOTCH 1, STAR, STATSb and DIM. The knowledge about the function of ZFP36L1 and its role in post-transcriptional regulation in B-cell development is extremely limited. The primary aim of this project was to investigate role of ZFP36L1 in regulating …
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Notch Signaling Is Important in the Survival, Proliferation, and Self-Renewal of the Putative Breast Cancer Stem Cell Population
… development of novel therapeutic strategies. Notch signaling, which is dysregulated in breast cancer and has been implicated in mammary stem cell self-renewal, and can be effectively blocked by gamma-secretase inhibitors (GSIs). While GSIs are currently in clinical trials for breast cancer, it …
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RNA binding proteins ZFP36 and ZFP36L1 limit CD8+ T cell differentiation and effector function
… by ZFP36L1 and transcription factors IRF8 and Notch-1, and multiple cytokines and chemokines, including IFN-γ, TNF-α, IL-2 and CCL3/4. In addition, I describe a novel reporter mouse model of ZFP36L1 with an N-terminal fusion of a red-fluorescent protein expressed from the endogenous Zfp36l1 …
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Ehrlichia chaffeensis Activates Notch Signaling Through SLiM Mimicry to Inhibit Apoptosis
… involve activation of Wnt, Hedeghog and Notch signaling pathways. Interestingly, the E. chaffeensis tandem repeat effector, TRP120, has been shown to interact with host proteins important for activation and regulation of conserved signaling pathways including Wnt, Notch and Sonic …
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Investigating Notch/Dll4 signalling in retinal microvascular cells in health and disease
… roles governing endothelial function are the Notch and endothelial nitric oxide synthase (eNOS) signalling pathways: currently, the interaction between these pathways is poorly described. <br/><br/>In part 1 we developed a heterologous system to investigate the effect of eNOS on Notch …
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Regulation of Intestinal Development and Function in Early-Life Pigs
… gaps remain regarding how Wnt/ β-catenin and Notch signaling pathways influence intestinal remodeling during the early life of pigs. Collectively, these gaps highlight the need for targeted nutritional or molecular interventions during critical developmental phases during the early life of …