Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Notch target"”.
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The Notch Target Hes4 Promotes Osteosarcoma Tumor Growth and Metastasis By Inhibiting Osteogenic Differentiation, and Has Potential As A Prognostic Biomarker For Newly Diagnosed Patients With High Grade Osteosarcoma.
… and homeostasis. One such pathway is the Notch signaling pathway. We hypothesized that the Notch downstream target Hairy/Enhancer of Split 4 (Hes4) is important in the pathogenesis of OS, and thus can be used as a biomarker for OS at the time of diagnosis.</p> <p>The differentiation status …
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Mechanistic Insights into the Notch signalling pathway through Molecular Condensation
… pathway in interpreting this information is the Notch signalling pathway. It is currently poorly understood how Notch is able to play a titratable role in signal transduction as our current model does not effectively translate how fluctuations in Notch signalling lead to dynamic changes in Notch …
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Investigating novel direct Notch targets in Drosophila neural stem cells
Notch signalling is an evolutionary highly conserved signalling pathway. It plays various important roles in the regulation of many fundamental cellular processes such as proliferation, stem cell maintenance and differentiation during embryonic and adult development. Notch signalling has a simple …
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Notch Signaling Inhibited By Ikaros1 In Human T-Cell Acute Lymphoblastic Leukemia
<p>The highly conserved Notch signaling pathway regulates cell growth, differentiation, survival and apoptosis. In hematopoiesis, Notch signaling drives commitment to the T-cell fate and promotes differentiation, T-cell receptor signaling and immune function. In T-cells, Notch signaling is …
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Notch Signaling in Human Neuroblastoma Cells
… of the SNS. Hash-1 is a component of the Notch signaling cascade, which is involved in many cell fate decisions. In general, Notch activity maintains a pool of undifferentiated cells and dysregulated Notch signaling has been linked to development of several cancers. It has been shown that …
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The role of notch signaling in the regulation of proliferation and cell differentiation during embryonic and postnatal pituitary development
… unclear. Previous studies have implicated the Notch signaling pathway in these processes, both in the pituitary and in other developing tissues. In order to more specifically define the role of Notch signaling during different stages of pituitary development, we utilized pituitary-specific …
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A study of Notch signalling in developmental angiogenesis
… regulated. Previous studies have shown that the Notch ligand, Delta-like 4 (Dll4), is prominently expressed in tip cells, therefore suggesting a role of Notch signalling in its regulation. In the mouse, suppression of Notch signalling by pharmacological inhibition of γ-secretase or genetic …
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Notch Signaling in Neuroblastoma and Renal Cell Carcinoma
The Notch signaling pathway governs cell functions essential for normal development and organogenesis. Aberrant Notch signaling has been implicated in tumorigenesis by perturbing control of proliferation, differentiation, apoptosis, migration and angiogenesis. Neuroblastoma is an embryonal tumor …
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Identifying notch-regulated genes using a specific notch signaling inhibitor
… by several signaling pathways, notably the notch signaling pathway. Gamma-secretase, an enzyme crucial for initiating notch signaling, can be inhibited by DAPT. However, DAPT also targets non-Notch substrates, complicating the identification of genes specifically regulated by Notch. To …
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The subnuclear localisation of Notch responsive genes
Title: The subnuclear localisation of Notch responsive genes. Candidate Name: Matthew Jones Notch signalling is a highly conserved cell-cell communication pathway with critical roles in metazoan development and mutations in Notch pathway components are implicated in many types of cancer. Notch is …
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Investigating the relationship between clock gene stability and the pace of the vertebrate segmentation clock
… suggest that sustained rapid oscillations of Notch-regulated gene transcription in the PSM depend on transient negative feedback loops that rely on unstable protein products. However, the pacemaker mechanism that underlies this segmentation clock is poorly understood and little experimental …
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Regulation of VEGF-activated signalling by the plasma membrane calcium ATPase 4 in endothelial cells
… we have screened gene arrays related to Notch signalling or extracellular matrix-Cell Adhesion Molecule (ECM-CAM) pathway using RNA isolated from PMCA4-silenced (or control) HUVEC. Changes in gene expression after PMCA4 knockdown have been further validated by TaqMan-based qPCR in HUVEC …
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Der Einfluss des Y-box-Proteins-1 (YB-1) auf den Notch-vermittelten Signaltransduktionsweg
… hybrid screen yielded, amongst other proteins, Notch-3 receptor as a direct interaction partner for YB-1. The human Notch receptor superfamily comprises four members of transmembrane receptors that are involved into cellular processes, such as differentiation, proliferation and apoptosis. …
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Probing the druggability of the Notch1 ankyrin domain using a fragment-based approach
Notch signalling is a highly conserved pathway that is important in the developmental processes that control cell differentiation and cell fates. This canonical pathway involves binding of a transmembrane ligand in one cell to the extraceullular domain of a transmembrane Notch receptor in an …
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The Role of Notch Signalling in Amplifying the Cellular Response to Sonic Hedgehog during Dorsal-Ventral Patterning of the Spinal Cord
… to adopt a specific neuronal fate.<br/><br/>The Notch pathway plays a crucial role during neurogenesis of both invertebrate and vertebrate embryos. It has also been demonstrated that the Notch and Shh signalling pathways can interplay in various developmental contexts. In this project, I have …
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Investigating transcription factor dynamics and chromatin environment during Notch response
… cell fate determination and tissue assembly. Notch signalling is one such, highly conserved, pathway in multicellular animals that regulates a large diversity of developmental processes. Its function is crucial for normal development and its misregulation is associated with diseases including …