Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"Notch signalling"”.
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FKBP14 in Notch Signalling and Drosophila Development
… growing list of transmembrane proteins including Notch and Amyloid Precursor Protein. Autosomal dominant mutations in the genes encoding human PS have been closely linked to cases of early onset familial Alzheimer's Disease (FAD), and these FAD-linked PS mutations influence the activity of …
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A study of Notch signalling in developmental angiogenesis
… regulated. Previous studies have shown that the Notch ligand, Delta-like 4 (Dll4), is prominently expressed in tip cells, therefore suggesting a role of Notch signalling in its regulation. In the mouse, suppression of Notch signalling by pharmacological inhibition of γ-secretase or genetic …
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Transcription and chromatin dynamics in the Notch signalling response
… in different cell types, often directed by cell signalling pathways and the pre-existing chromatin environment. The highly-conserved Notch signalling pathway is involved in many cell fate decisions during development, activating different target genes in different contexts. Upon ligand binding, …
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Notch signalling in spinal cord patterning: Crosstalk and fate decisions
… with particular focus on the highly conserved Notch signalling pathway. The major, and most well studied, role of Notch signalling during neural development is progenitor maintenance. This thesis explores the additional roles of Notch signalling in signalling crosstalk and cell fate decisions. …
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Mechanistic Insights into the Notch signalling pathway through Molecular Condensation
… identity, and cell positional information. A key signalling pathway in interpreting this information is the Notch signalling pathway. It is currently poorly understood how Notch is able to play a titratable role in signal transduction as our current model does not effectively translate how …
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Novel Notch signalling dynamics within the molecular oscillator underlying vertebrate segmentation
… machinery are intracellular constituents of the Notch, Wnt and FGF signalling pathways. However, Notch signalling has been shown to be crucially important in establishing and regulating the segmentation clock oscillator and is essential for somitogenesis in higher vertebrates. In this thesis, a …
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Investigating the role of Notch signalling during mesoderm development and cell proliferation
… developmental and diseases processes. The Notch signalling pathway is a cell-contact-dependent pathway known to regulate cell proliferation, differentiation, and specification in a context-dependent manner. Owing to its crucial function during all stages of life, it is highly conserved …
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A novel genome-wide approach to identify in vivo targets of Notch signalling
The Notch signalling pathway regulates many developmental processes in metazoan embryos and adults such as cell proliferation, stem cell maintenance, cell fate specification and apoptosis. Despite the importance of this pathway, few targets have been identified, with the Hes (Hairy and …
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The Role of Notch Signalling in Amplifying the Cellular Response to Sonic Hedgehog during Dorsal-Ventral Patterning of the Spinal Cord
… to adopt a specific neuronal fate.<br/><br/>The Notch pathway plays a crucial role during neurogenesis of both invertebrate and vertebrate embryos. It has also been demonstrated that the Notch and Shh signalling pathways can interplay in various developmental contexts. In this project, I have …
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Molecular Control of Tooth Mesenchymal Stem Cell Activation
… and their progeny, particularly the role of Notch signalling in this process. Methods Isolation of proposed putative MSC containing and known mesenchymal transit amplifying cell (MTAC) containing regions were undertaken. Laser capture microdissection and subsequent comparative analysis of MSC …
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Stem and Progenitor Cells in Homeostatic Maintenance and Perturbation of the Pulmonary Epithelium
… RNA sequencing, which also indicates reduced signalling between SecC-derived PIK3CAH1047R mutant cells and tissue-sharing basal cells. I also performed a detailed analysis examining the ability of intralobar secretory cells with constitutive Notch signalling to contribute to the alveolar …
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Development of an in vitro human lung organoid system to study alveolar type 2 stem cell maintenance and dysfunction during disease
… of differentiation capacity. High Wnt signalling and FGF7 presence were found to be essential for primary hAT2 self-renewal, while reduction of Wnt signalling led to hAT1 differentiation. To understand hAT2 dysregulation during disease, hypoxia was used to mimic an aspect of the IPF …
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Investigating novel direct Notch targets in Drosophila neural stem cells
Notch signalling is an evolutionary highly conserved signalling pathway. It plays various important roles in the regulation of many fundamental cellular processes such as proliferation, stem cell maintenance and differentiation during embryonic and adult development. Notch signalling has a simple …
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Probing the druggability of the Notch1 ankyrin domain using a fragment-based approach
Notch signalling is a highly conserved pathway that is important in the developmental processes that control cell differentiation and cell fates. This canonical pathway involves binding of a transmembrane ligand in one cell to the extraceullular domain of a transmembrane Notch receptor in an …
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Studies of the hindbrain roof plate organiser in the chick embryo
… the gdf7- positive roof plate boundary and its signalling properties can be regenerated in roof platederived tissue at the interface between hindbrain roof plate epithelium and neuroepithelium. Further, this gdf7-positive boundary is required for the expression of cath1, which marks the …
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Regulation of Notch Ligands Dll1 and Jag1 by Pax6 during cortical development
… by Pax6 in the developing cortex. Members of the Notch signalling pathway were potential Pax6 targets of particular interest since Notch signalling plays a crucial role in the maintenance of neural progenitor cells during development and consequently plays a critical role during corticogenesis. …
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Investigating Notch/Dll4 signalling in retinal microvascular cells in health and disease
… of Prematurity (ROP). A vast repertoire of signalling pathways have been identified in regulating the functional maintenance of endothelial cells. Two such pathways known to have crucial regulatory roles governing endothelial function are the Notch and endothelial nitric oxide synthase …
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Interpreting Notch signals: characterisation of dynamic transcription hubs by live imaging
The Notch signalling pathway, crucial for development, activates upon cell-to-cell contact. Despite lacking any amplification, activation of target genes is achieved robustly and efficiently after contact-induced cleavage of the Notch transmembrane protein. How relatively few molecules of the …
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Investigating transcription factor dynamics and chromatin environment during Notch response
During development, a multitude of cell signalling pathways control patterning, cell fate determination and tissue assembly. Notch signalling is one such, highly conserved, pathway in multicellular animals that regulates a large diversity of developmental processes. Its function is crucial for …
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