Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 94 for “"Notch signaling"”.
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Notch Signaling in Human Neuroblastoma Cells
… of the SNS. Hash-1 is a component of the Notch signaling cascade, which is involved in many cell fate decisions. In general, Notch activity maintains a pool of undifferentiated cells and dysregulated Notch signaling has been linked to development of several cancers. It has been shown that …
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Kinetics of notch signaling during osteoclastogenesis
… attributed to decreased estrogen levels. The Notch signal pathway is a highly conserved direct cell communication pathway known to regulate cell proliferation, differentiation and survival in many cell types including the differentiation of osteoclasts from bone marrow macrophages (BMMs). …
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NOTCH SIGNALING REGULATES ADIPOGENESIS AND ENERGY METABOLISM
Evolutionarily unprepared for high caloric diets and sedentary lifestyles, humans are now unprecedentedly susceptible to obesity and its associated metabolic disorders. Obesity is resulted from malfunction of the overloaded white adipocytes, which are the primary default storage sites of energy …
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ROLE OF NOTCH SIGNALING IN BREAST CANCER METASTASIS
Notch signaling is often and aberrantly activated by hypoxia during tumor progression; however, the exact pathological role of hypoxia-induced Notch signaling in tumor metastasis is as yet poorly understood. In the first part of this study, we aimed to define the mechanism of Notch ligand …
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Notch Signaling in Neuroblastoma and Renal Cell Carcinoma
The Notch signaling pathway governs cell functions essential for normal development and organogenesis. Aberrant Notch signaling has been implicated in tumorigenesis by perturbing control of proliferation, differentiation, apoptosis, migration and angiogenesis. Neuroblastoma is an embryonal tumor …
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Role of Notch Signaling in T Cell Polarization
… my thesis, I aimed to study the role of Notch cell surface receptors in Th17 differentiation. Using in vitro Th17 differentiation assays of human naïve CD4+ T cells, I have shown that Notch signaling, particularly Notch1, plays a crucial role in Th17 polarization. By using pharmacological …
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Zebrafish Posterior Lateral Line Organogenesis Regulation by Notch Signaling
… chages. Results in this thesis demonstrate that Notch signaling is an integral part of the feedback loop between Wnt and Fgf signaling that underlies the self‐organization of rosette‐shaped sensory organs in the zebrafish lateral line system. Notch cell autonomously induces apical constriction …
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Identifying notch-regulated genes using a specific notch signaling inhibitor
… their differentiation is regulated by several signaling pathways, notably the notch signaling pathway. Gamma-secretase, an enzyme crucial for initiating notch signaling, can be inhibited by DAPT. However, DAPT also targets non-Notch substrates, complicating the identification of genes …
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Notch signaling pathway in human vascular smooth muscle cell differentiation
Notch receptor-ligand interactions are a highly conserved mechanism, originally described in developmental studies using Drosophilae, that regulate inter-cell communication and dictate, in part, vascular smooth muscle cell (VSMC) fate in response to mechanical stimuli. VSMC differentiation is a …
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Notch Signaling Determines Lymphatic Cell Fate and Regulates Sprouting Lymphangiogenesis
… as wound healing and cancer. We show that the Notch signaling pathway is a regulator of both developmental and pathological lymphangiogenesis. Notch1 and Notch4 are expressed by the lymphatic endothelium, and Delta-like ligand 4 (Dll4) is the predominantly expressed Notch ligand in the …
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The Dual Role of Notch Signaling During Motor Neuron Differentiation
… key mediator of cell-to-cell communication, the Notch signaling pathway has been implicated as a primary player in the generation of intra-domain cellular diversity throughout development. Despite this, the role of Notch signaling in contributing to neural diversity within the motor neuron …
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Notch signaling and cell cycle inhibitor regulation in pituitary organogenesis
… expansion is regulated. We have investigated signaling pathways active during development, a time of rapid organ growth, to understand the process of pituitary progenitor cell division. In development, progenitors choose between proliferation and cell cycle exit, followed by differentiation. …
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Local and Systemic Consequences of Reducing Notch Signaling in Skin Keratinocytes
Notch is a transmembrane receptor that mediates short-range signaling between neighboring cells. Notch signaling has been implicated in various cellular and developmental processes essential in the life of metazoans. Specifically, Notch signaling plays a critical role in mammalian skin. Removal of …
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Ehrlichia chaffeensis Activates Notch Signaling Through SLiM Mimicry to Inhibit Apoptosis
… involve activation of Wnt, Hedeghog and Notch signaling pathways. Interestingly, the E. chaffeensis tandem repeat effector, TRP120, has been shown to interact with host proteins important for activation and regulation of conserved signaling pathways including Wnt, Notch and Sonic …
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The Role of IGF-1 and Notch Signaling in Thoracic Malignancies.
… of MM. Insulin like growth factor-1 (IGF-1) signaling plays a central role in all thoracic malignancies and in the process of SV40-mediated malignant transformation of human cells. We have found that in SV40-transformed human mesothelial cells (HM) the Large T antigen (Tag), p53, pRb and p300 …
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The Role of Notch Signaling in the Pathogenesis of Acute Promyelocytic Leukemia
… then observed that human APL overexpresses the Notch ligand Jagged-1: JAG1) compared to other AML and normal promyelocytes. Unlike many APL signature genes, overexpression of JAG1 is also found in human APL cell lines and in murine APL. We hypothesized that Notch signaling, which has known roles …
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Notch Signaling Inhibited By Ikaros1 In Human T-Cell Acute Lymphoblastic Leukemia
<p>The highly conserved Notch signaling pathway regulates cell growth, differentiation, survival and apoptosis. In hematopoiesis, Notch signaling drives commitment to the T-cell fate and promotes differentiation, T-cell receptor signaling and immune function. In T-cells, Notch signaling is …
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Role of the adaptor protein, beta-arrestin1, in the Notch signaling pathway
The Notch receptor is part of a highly conserved signaling pathway shared in Drosophila, C. elegans and mammals. Extensive studies of Notch signaling have revealed its participation in the development of diverse organ systems including brain, blood cells, blood vessels, gut, and skin. Many genetic …
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Uncovering molecular mechanisms of the notch signaling pathway in the regulation of pituitary gland development
… from our laboratory have demonstrated that the Notch signaling pathway is an important regulator of pituitary cell fate choice. Specifically, Notch signaling is necessary for pituitary progenitor maintenance and coordinates the balance of endocrine cell differentiation. However, the mechanism by …
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