Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"Normoxic conditions"”.
-
Enhanced Blue Crab Predation on Rangia Clams after Exposure to Hypoxia
… were exposed experimentally to severe hypoxic conditions (< 0.75 mg/l) for 72-hours and then presented to blue crabs. One hypoxic and one normoxic clam were added to each aquarium containing a blue crab for each trial, and crab feeding choices were observed and recorded. I found prey choice …
-
Hypoxia-inducible factor-1 alpha (HIF-1alpha) and its role in the hypoxic preconditioning and gene expression patterns in zebrafish ( Danio rerio) embryos
… levels of hypoxia and then returned to normoxic conditions. During a subsequent exposure to hypoxia, the pre-exposed animals may exhibit increased tolerance compared to naive animals. I have demonstrated, by analysis of critical PO2's (Pcrit), that zebrafish embryos can be preconditioned …
-
Dichloroacetate, a inhibitor of pyruvate dehydrogenase kinase-1, attenuates hypoxia-induced resistance to 5-fluorouracil in gastric cancer cells
… had a lower sensitivity to 5-FU under hypoxic conditions compared to normoxic conditions. Moreover, the addition of 20 mM DCA only increased the sensitivity of these cells to 5-FU under hypoxic conditions, and the resistance to 5-FU under hypoxia was also attenuated in PDK1 knockdown cell …
-
Studies on biological activities of Scottish plants.
… were tested in in both hypoxic and normoxic conditions, using 3 cell lines CaCo2, MCF -7, and MDA 468 and it was observed that they had higher acitivty in hypoxic conditions compared to normoxic conditions, an interesting finding as often larger tumours have hypoxic states in the …
-
Investigating the Response of the Eastern Oyster (Crassostrea virginica) to Low Dissolved Oxygen Conditions
… It is important to investigate the impacts of DO conditions on oyster mortality, biomass, size, and condition during these freshening events. Under controlled laboratory experiments, this thesis investigated 1) the response of oysters to microxic, hypoxic, and normoxic conditions 2) the response …
-
Exploring the Molecular Mechanisms of Human Cytoglobin and its Role in Cancer
… functions, acting as a tumour suppressor under normoxic conditions and an oncogene under hypoxic conditions. Additionally, Cygb is proposed to be involved in cancer therapy resistance by protecting tumour cells from harsh environments including high free radical levels generated with …
-
Preconditioning Methods in Cartilage Tissue Engineering: Influences of Silk Material Properties and Hypoxia on Chondrogenesis
… dissertation is on utilizing the physiological conditions found in joints to regulate biological behavior of cells. The first factor that was studied was the extracellular matrix. Two formats of silk fibroin-hydrogel and porous scaffolds - were examined for their potential as a supporting …
-
The Proteomic Response of Gill Tissue in Tidally and Subtidally-Acclimated California Mussels, Mytilus californianus, to Acute Emersion-Induced Anoxia
… emersion-induced anoxia, in contrast to normoxic conditions experienced during submersion. We therefore hypothesized that acclimation to a tidal rhythm, as opposed to a rhythm of constant submersion, preconditions the proteome of the California mussel, <em>Mytilus</em><em> …
-
Modulation of neutrophil degranulation by hypoxia
… supernatants from neutrophils cultured under normoxic conditions; this damage was protein- and protease-dependent. This pattern of damage was seen consistently across lung adenocarcinoma-derived epithelial cells, primary immortalised lung epithelial cells, and primary human bronchial …
-
An in Vitro Microenvironment for Nucleus Pulposus Regeneration
… DECM and comparable to SDSC derived DECM. Normoxic conditions during DECM preparation were more beneficial to cell proliferation, but hypoxic conditions promoted differentiation towards the NP lineage. Finally, hypoxic conditions during pellet culture promoted NPC viability and …
-
Flood Survival Strategies of Overwintering Snakes
… that inhabit my study area. I varied water level conditions and measured activity and dive behaviours continuously during experiments. I found differences between species in their resting metabolic rate, which I attributed to body size differences. I confirmed, cutaneous respiration occurs at a …
-
Investigating pseudohypoxia in renal cells deficient in fumarate hydratase.
… activation of HIF-1 under abundant oxygen conditions. This phenomenon, known as 'pseudohypoxia', is considered an important driver of tumorigenesis. However, the role of HIF activation and pseudohypoxia in FH-deficient renal cells is unclear. This aim of this thesis was to delineate the …
-
Cellular Coping Mechanisms to Hypoxia in the Longhorn Sculpin (Myoxocephalus octodecemspinosus) Brain
… at each of the following time points: control/normoxic conditions (T=0 h); hypoxic conditions (T=3 h); early (T=7 h total; 4 hours post-hypoxia), and late (T=11 h total; 8 hours post-hypoxia) normoxic recovery. The importance of hypoxia-induced apoptotic pathways has been suggested in other …
-
The Role of Secondary and Tertiary Structure in the Cap-Independent Translation of FGF-9 and HIF-1-alpha
<p>Under normoxic conditions, eukaryotes initiate translation of RNA through eIF4E recognition of the 5’ cap. However, under cellular stress, eukaryotic translation must be initiated through a 4E-independent, or “cap-independent” mechanism, involving eukaryotic initiation factor 4G (eIF4G) binding …
-
Oncostatin M Receptor Overexpression Promotes Tumour Progression in Squamous Cell Carcinoma, via Hypoxia Signalling and Multiple Effects on the Tumour Microenvironment
… factor 1a and 2a (HIF1a, HIF2a) signalling in normoxic conditions, to promote pro-angiogenic signalling. Furthermore, hypoxic conditions were found to enhance OSM signalling in OSMR overexpressing cells leading to increased expression of markers of epithelial to mesenchymal transition, …
-
Investigation into the role of HMGb1 in relation to myofibroblasts and cancer cells exposed to various conditions
… cancer cell lines (HT29, MCF-7 and A549) under normoxic conditions. Recombinant HMGb1 (10ng/ml) was shown to trigger proliferation in myofibroblasts cells via activation of PI3K and MEK1/2. Conditioned medium collected from glucose deprived HT29 cells was shown to stimulate migration and …
-
Effect of Tumor Microenvironmental Conditions on Non Small Cell Lung Cancer
<p>Tumor microenvironmental conditions play a vital role in promoting metastasis and tumor recurrence. Due to inefficient vasculature, cancer cells experience hypoxia, glucose deprivation and low pH even during the early stages of tumor growth. Tumor cells are proposed to adapt to these …
-
Role of kinins in mediating vascular function in healthy pregnancy and pre-eclampsia
… mechanism in healthy HUVECs cultured in normoxic conditions. HUVECs isolated from women with pre-eclampsia cultured under normoxia and HUVECs from healthy pregnancies cultured under hypoxia exhibited greater levels of angiogenic branching compared with healthy normoxic cells, but were …
-
Regulation of the hif-1-dependent hypoxic stress response by C. elegans
… (known as EGLN, PHD, or HIF-PH in mammals). In normoxic conditions, EGL-9 uses ambient O2 to hydroxylate HIF-1. Hydroxylated HIF-1 is recognized by the von Hippel-Lindau (VHL-1) tumor suppressor protein, a component of an E3-ubiquitin ligase complex that targets HIF-1 for proteasomal …
-
Soft sediment ecology of Lough Hyne Marine Reserve - spatial and temporal patterns
… first taxon to make use of ameliorating oxygen conditions in autumn, by darting below the thermocline depth, most likely to scavenge. This was indicated by tracks that they left on the surface of the Trough floor. Some species, most noticeably Fries’ goby Lesueurigobius friesii, migrated below …
Page 1 of 2