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Showing 1 to 4 of 4 for “"Normothermic machine perfusion"”.
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Studies of normothermic machine perfusion in human kidney transplantation
Normothermic machine perfusion (NMP) of human kidneys is a new preservation technique that allows for the assessment and treatment of kidneys prior to transplantation. However, there is currently no standard protocol for NMP of kidneys and limited understanding of the underlying mechanisms that …
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Examining the regional physiology of the transplant kidney during normothermic machine perfusion.
Ischaemia-reperfusion injury (IRI) is an unavoidable consequence of deceased-donor kidney transplantation that has a profound effect upon both immediate and long-term graft function. Disruption to microvascular perfusion (MVP) and tissue oxygenation (PtO2) are central to the development of IRI, but …
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Optimizing the delivery of pre-transplantation therapies during normothermic machine perfusion of human kidneys
… have an increased susceptibility to ischemia reperfusion injury and the use of these organs may ultimately result in post-transplant complications like graft loss and recipient death. Normothermic machine perfusion has emerged as a platform for ex vivo assessment and repair to increase …
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Enzymatic blood group conversion of human kidneys for transplantation
… of these enzymes to human kidneys with ex vivo normothermic and hypothermic machine perfusion technologies to produce enzyme converted (ABOe) blood group O kidneys. Firstly, an a-galactosidase enzyme from *Bacteroides fragilis* was used to remove blood group B antigens from human tissue *in …